作者:2017-12-05浏览次数:22966

毕 艳

博士研究生导师简介

姓名

毕艳

研究方向:

内分泌与代谢病

联系方式

电话:(02583304616-61436

Email: biyan@nju.edu.cn

学术兼职:

中华医学会糖尿病学分会委员

中华医学会糖尿病学分会肥胖与糖尿病学组副组长

江苏省医学会糖尿病学分会副主任委员

江苏省医师协会糖尿病专业委员会副主任委员

个人简介

  1. 工作简历

医学博士,主任医师,博士生导师,南京鼓楼医院科技处处长兼内分泌科副主任,鼓楼区人大代表,入选江苏省医学重点人才,江苏省333高层次人才培养工程,江苏省六大人才高峰,南京市有突出贡献中青年专家。

鼓楼医院内分泌科临床和学术影响力不断提升,目前是国家临床重点专科,国家代谢性疾病临床医学研究中心分中心(省级中心),江苏省医学重点学科,江苏省内分泌专业质量控制中心,江苏省代谢性疾病诊疗中心,南京内分泌学临床医学中心,入选复旦榜2019年度最佳专科排行榜第12名(江苏排名前列)。

  1. 科研情况简介

研究集中于糖尿病和肥胖的临床与基础研究,取得多项原创性成果,在Journal of HepatologyDiabetes CareNature CommunicationsDiabetes等杂志以第一及通讯作者发表SCI论著65篇。承担国家自然科学基金重点项目1项,面上项目3项,相关研究获20122014年度中国糖尿病十大研究最具影响力研究奖,2019年度中华医学会糖尿病学分会青年委员会杰出青年科学研究奖,中国胰岛素分泌研究新星奖,中华糖尿病杂志优秀论文一等奖,江苏医学科技奖一等奖,江苏省医学新技术引进一等奖。

  1. 研究兴趣

  1. 2型糖尿病

  2. 肥胖

代表性论文[5年通讯作者和第一作者]

  1. Chen C#, Wang W, Zhou W, Jin J, Chen W, Zhu D, Bi Y*. Nocturnal ventricular arrhythmias are associated with the severity of cardiovascular autonomic neuropathy in type 2 diabetes. J Diabetes. 2019;11(10):794-801. (IF=3.28)

  2. Jin J#, Wang W#, Gu T#, Chen C, Sun J, Chen W, Bi Y*, Zhu D*. Low serum bilirubin levels contribute to the presence and progression of distal symmetrical polyneuropathy in Chinese patients with type 2 diabetes. Diabetes Metab. 2019;45(1):47-52. (IF=4.731)

  3. Feng W#, Yin T#, Chu X, Shan X, Jiang C, Wang Y, Qian Y, Zhu D*, Sun X*, Bi Y*. Metabolic effects and safety of Roux-en-Y gastric bypass surgery vs. conventional medication in obese Chinese patients with type 2 diabetes. Diabetes Metab Res Rev. 2019;35(5):e3138. (IF=3.314)

  4. Zhang Z#, Zhang B#, Wang X#, Zhang X, Yang QX, Qing Z, Zhang W, Zhu D#, Bi Y*. Olfactory Dysfunction Mediates Adiposity in Cognitive Impairment of Type 2 Diabetes: Insights From Clinical and Functional Neuroimaging Studies. Diabetes Care. 2019;42(7):1274-1283. (IF=16.019)

  5. Wang H#, Shen L#, Sun X#, Liu F#, Feng W, Jiang C, Chu X, Ye X, Jiang C, Wang Y, Zhang P, Zang M, Zhu D#, Bi Y*. Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity. Nat Commun. 2019;10(1):3254. (IF=12.121)

  6. Gu T#, Ma J#, Zhang Q#, Zhu L#, Zhang H, Xu L, Cheng J, Shi B, Li D, Shao J, Sun Z, Zhong S, Bi Y*, Zhu D*. Comparative effect of saxagliptin and glimepiride with a composite endpoint of adequate glycaemic control without hypoglycaemia and without weight gain in patients uncontrolled with metformin therapy: Results from the SPECIFY study, a 48-week, multi-centre, randomized, controlled trial. Diabetes Obes Metab. 2019; 21(4):939-948. (IF=5.900)

  7. Tang W#, Zhang B#, Wang H, Li M, Wang H, Liu F, Zhu D, Bi Y*. Improved skeletal muscle energy metabolism relates to the recovery of β cell function by intensive insulin therapy in drug naïve type 2 diabetes. Diabetes Metab Res Rev. 2019;35(7):e3177. (IF=3.314)

  8. Xu Q#, Ge Z#, Hu J, Shen S, Bi Y*, Zhu D. The Association of gestational weight gain and adverse pregnancy outcomes in women with gestational diabetes mellitus. Endocr Pract. 2019;25(11):1137-1150. (IF=3.869)

  9. Zhang B#, Shen S#, Gu T, Hong T, Liu J, Sun J, Wang H, Bi Y*, Zhu D*. Increased circulating conjugated primary bile acids are associated with hyperandrogenism in women with polycystic ovary syndrome. J Steroid Biochem Mol Biol. 2019;189:171-175. (IF=3.813)

  10. Hong T#, Ge Z#, Zhang B, Meng R, Zhu D*, Bi Y*. Erythropoietin suppresses hepatic steatosis and obesity by inhibiting endoplasmic reticulum stress and upregulating fibroblast growth factor 21. Int J Mol Med. 2019;44(2):469-478. (IF=3.098)

  11. Hong T#, Lu J#, Zhang P, Zhang Z, Xu Q, Li Y, Cui N, Grijalva A, Murray EM, Del Aguila MA, Bi Y*. Efficacy and Safety of Basal Analog Regimens in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Diabetes Ther. 2019;10(3):1051-1066. (IF=3.179)   

  12. Liu F#, Wang H#, Feng W#, Ye X, Sun X, Jiang C, Chu X, Zhang P, Jiang C, Wang Y, Zhu D*, Bi Y*. Type 1 innate lymphoid cells are associated with type 2 diabetes. Diabetes Metab. 2019;45(4):341-346. (IF=4.731)

  13. Yuyang Ze#, Xiaowen Zhang#, Fei Shao, Lin Zhu, Shanmei Shen*, Dalong Zhu*, Yan Bi*. Active Surveillance of Low-risk Papillary Thyroid Carcinoma: A Promising Strategy Requiring Additional Evidence. J Cancer Res Clin Oncol. 2019;145(11):2751-2759. (IF=3.656)  

  14. Pengzi Zhang#, Wenghuan Feng#, Xuehui Chu#, Xitai Sun, Dalong Zhu, Yan Bi*. A Newly Noninvasive Model for Prediction of Non-Alcoholic Fatty Liver Disease: Utility of Serum Prolactin Levels. BMC Gastroenterol. 2019;19(1):202. (IF=2.489)

  15. Gu T#, Zhou W#, Sun J#, Wang J, Zhu D*, Bi Y*. Gender and Age Differences in Lipid Profile Among Chinese Adults in Nanjing: a Retrospective Study of Over 230,000 Individuals from 2009 to 2015. Exp Clin Endocrinol Diabetes, 2018 Jul;126(7):429-436. (IF=1.927)  

  16. Ling Q#, Lu J#, Li J, Xu Q, Zhu D*, Bi Y*. Risk of beta-cell antoimmunity presence of progression to type 1 diabetes: a systemic review and meta-analysis. J Autoimmu, 2018 Jan;86:9-18. (IF=7.543)  

  17. Zhang B#, Wang J#, Shen S#, Liu J, Sun J, Gu T, Ye X, Zhu D*, Bi Y*. Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome. Biomed Res Int, 2018 Mar 8;2018:6869705. (IF=2.197)

  18. Zhang P#, Ge Z#, Wang H#, Feng W, Sun X, Chu X, Jiang C, Wang Y, Zhu D*, Bi Y*. Prolactin improves hepatic steatosis via CD36 pathway. J Hepatol, 2018 Jun;68(6):1247-1255. (IF=18.946)

  19. Zhang Z#, Zhang B#, Wang X#, Zhang X, Yang QX, Qing Z, Lu J, Bi Y*, Zhu D*. Altered Odor-Induced Brain Activity as an Early Manifestation of Cognitive Decline in Patients with Type 2 Diabetes. Diabetes, 2018 May;67(5):994-1006. (IF=7.199)

  20. Hong T#, Ge Z#, Meng R, Wang H, Zhang P, Tang S, Lu J, Gu T, Zhu D*, Bi Y*. Erythropoietin alleviates hepatic steatosis by activating SIRT1-mediated autophagy. Biochim Biophys Acta, 2018 Jun;1863(6):595-603. (IF=4.402)

  21. Sun J#, Zhou W#, Gu T#, Zhu D, Bi Y*. A retrospective study on association between obesity and cardiovascular risk diseases with aging in Chinese adults. Sci Rep, 2018 Apr 11;8(1):5806. (IF=4.011)

  22. Zhang B#, Wang J#, Shen S#, Liu J, Sun J, Gu T, Zhu D*, Bi Y*. Subclinical hypothyroidism is not a risk factor for polycystic ovary syndrome in obese women of reproductive age. Gynecol Endocrinol, 2018 Oct;34(10):875-879. (IF=1.406)

  23. Zhang X#, Shao F#, Zhu L, Ze Y, Zhu D*, Bi Y*. Cardiovascular and microvascular outcomes of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized controlled cardiovascular outcome trials with trial sequential analysis. BMC Pharmacol Toxicol, 2018 Sep 17;19(1):58. (IF=2.103)

  24. Lei Yu#, Wenhuan Feng#, Fangcen Liu, Sunyinyan Tang, Hongdong Wang, Dalong Zhu, Yan Bi*. Zoledronic acid induces a brown-like phenotype in white adipocytes. Int J Clin Exp Med, 2018;11(12):13407-13414. (IF=0.181)

  25. Tang S#, Wu W#, Tang W, Ge Z, Wang H, Hong T, Zhu D*, Bi Y*. Suppression of Rho-kinase 1 is responsible for insulin regulation of the AMPK/SREBP-1c pathway in skeletal muscle cells exposed to palmitate. Acta Diabetol, 2017 Jul; 54(7): 635-644. (IF=3.126)

  26. Feng W#, Wang H#, Zhang P, Gao C, Tao J, Ge Z, Zhu D*, Bi Y*. Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats. Biochim Biophys Acta Gen Subj, 2017 Jul; 1861(7):1801-1812. (IF=3.679)

  27. Zhang P#, Lu J#, Jing Y#, Tang S, Zhu D*, Bi Y*. Global Epidemiology of Diabetic Foot Ulceration: A Systematic Review and Meta-Analysis. Ann Med, 2017; 49(2): 106-116. (IF=3.007)   

  28. Zhang H#, Ge Z, Tang S, Meng R, Bi Y*, Zhu DL*. Erythropoietin ameliorates PA-induced insulin resistance through IRS/AKT/FOXO1, GSK-3β signaling pathway and inhibits inflammatory response in HepG2 cells. Mol Med Rep, 2017; 16(2): 2295-2301. (IF=1.922)   

  29. Tang W#, Tang S, Wang H, Ge Z, Zhu D*, Bi Y*. Insulin restores UCP3 activity and decreases energy surfeit to alleviate lipotoxicity in skeletal muscle. Int J Mol Med, 2017 Dec; 40(6): 2000-2010. (IF=2.784)   

  30. Lu Y, Li P, Gan W, Xu Q, Zhao X, Shen S, Feng W, Bi Y(共同通讯), Guo H, Zhu D. Clinical and pathological characteristics of hypertensive and normotensive adrenal pheochromocytomas. Exp Clin Endocrinol Diabetes, 2016, 124(6): 372-379. (IF: 1.665)

  31. Tang W, Xu Q, Hong T, Tong G, Feng W, Shen S, Bi Y(共同通讯), Zhu D. Comparative efficacy of anti-diabetic agents on nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized and non-randomized studies. Diabetes Metab Res Rev, 2016, 32(2): 200-216. (IF: 3.064)

  32. Wang HD#, Tang WJ, Zhang PZ, Zhang Z, He J, Zhu DL, Bi Y*. Modulation of gut microbiota contributes to effects of intensive insulin therapy on intestinal morphological alteration in high fat-diet treated mice. Acta Diabetol, 2020 Apr;57(4):455-467. (IF=3.418)

  33. Jun Hu#, Zhijuan Ge#, Qianyue Xu, Shanmei Shen, Yanmei Wang, Dalong Zhu, Yan Bi*. Influence of Fetal Sex on Perinatal Outcomes in Women With Gestational Diabetes Mellitus. Diabetes Metab Res Rev, 2020 Mar;36(3):e3245. (IF=3.314)

  34. Qianyue Xu#, Jing Lu#, Jun Hu, Zhijuan Ge, Dalong Zhu, Yan Bi*. Perinatal Outcomes in Pregnancies Complicated by Type 1 Diabetes Mellitus. Gynecol Endocrinol, 2020 Oct;36(10):879-884. (IF=1.571)

  35. Qing Ling#, Jing Lu#, Xiang Li, Chengcheng Qiao, Dalong Zhu*, Yan Bi*. Value of Capillary Glucose Profiles in Assessing Risk of Nocturnal Hypoglycemia in Type 1 Diabetes Based on Continuous Glucose Monitoring. Diabetes Ther, 2020;11(4):915-925. (IF=3.179)

  36. Lei Yu#, Haoran Wang#, Xiaoxue Han, Honghui Liu, Dalong Zhu, Wenhuan Feng*, Jinhui Wu*, Yan Bi*. Oxygen Therapy Alleviates Hepatic Steatosis by Inhibiting Hypoxia-Inducible factor-2α. J Endocrinol, 2020;246(1):57-67. (IF=4.041)

  37. Fangcen Liu#, Jielei He, Hongdong Wang, Dalong Zhu, Yan Bi*. Adipose Morphology: a Critical Factor in Regulation of Human Metabolic Diseases and Adipose Tissue Dysfunction. Obes Surg, 2020;30(12):5086-5100. (IF=3.412)

  38. Jie Li#, Haiyan Shangguan, Xiaoqian Chen, Xiao Ye, Bin Zhong, Pen Chen, Yamei Wang, Bin Xin, Yan Bi*, Dalong Zhu*. Advanced glycation end product levels were correlated with inflammation and carotid atherosclerosis in type 2 diabetes patients. Open Life Sci, 2020;15(1):364-372. (IF=0.938)

  39. Fangcen Liu#, Jielei He#, Boxun Liu#, Pengzi Zhang, Hongdong Wang, Xitai Sun, Xuehui Chu, Wenxian Guan, Wenhuan Feng, Yan Bi*, Dalong Zhu*. Association of Omental Adipocyte Hypertrophy and Fibrosis with Human Obesity and Type 2 Diabetes. Obesity (Silver Spring), 2021 Jun;29(6):976-984. (IF=5.002)

  40. Yanmei Wang#, Zhijuan Ge#, Lei Chen#, Jun Hu, Wenting Zhou, Shanmei Shen, Dalong Zhu*, Yan Bi*. Risk Prediction Model of Gestational Diabetes Mellitus in a Chinese Population Based on a Risk Scoring System. Diabetes Ther, 2021 Jun;12(6):1721-1734. (IF=2.945)

  41. Ning-Jing Zhang#, Yu-Zhe Fu#, Xiao-Dong Shan#, Ning Zhang, Xi-Tai Sun, Xue-Hui Chu, Yan Bi*, Da-Long Zhu*, Wen-Huan Feng*. Are Chinese Patients with Type 2 Diabetes and a Body Mass Index of 27.5-32.5 kg/m2 Suitable for Metabolic Surgery? A One-Year Post-Surgery Study. Diabetes Ther, 2021 May;12(5):1429-1444. (IF= IF=2.945)

  42. Jing Lu#, Shan-Mei Shen#, Qing Ling#, Bin Wang, Li-Rong Li, Wei Zhang, Duo-Duo Qu, Yan Bi*, Da-Long Zhu*. One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study. Stem Cell Res Ther, 2021 Jun 10;12(1):340. (IF=6.832)

  43. Yangyang Xia#, Chunming Jiang, Jing Lu, Jie Liu, Tianwei Gu*, Yan Bi*. Associations Between Obesity and Kidney Disease in Chinese Men and Women With Type 2 Diabetes: A Retrospective Cohort Study. Can J Diabetes, 2021 May 19;S1499-2671(21)00150-7. Online ahead of print. (IF=4.19)

  44. Yu Jin#, Weimin Wang#, Wei Chen#, Simin Guo, Chenxi Li, Dalong Zhu, Yan Bi*. Corneal confocal microscopy: A useful tool for diagnosis of small fiber neuropathy in type 2 diabetes. J Diabetes Investig, 2021 Jun 16. Online ahead of print. (IF=4.232)

  45. Fangcen Liu#, Jielei He#, Ye Zhu#, Hongdong Wang, Wenhuan Feng, Xitai Sun, Yan Bi*, Dalong Zhu*. Body Adiposity Index Is Predictive of Weight Loss after Roux-en-Y Gastric Bypass. Ann Nutr Metab, 2021 Aug 2;1-10. Online ahead of print. (IF=3.374)

承担科研项目[项目负责人]

  1. 泌乳素介导营养感应通过神经-内分泌机制调控肝脏脂质代谢稳态的研究,主持,2021-2025,国家自然科学基金重点项目,297

  2. ILC1/ILC2细胞免疫特性在脂肪组织纤维化发生发展中的作用及其机制研究,主持,2018-2021,国家自然科学基金面上项目,52

  3. AMPK在胰岛素抑制SREBP-1c活化而改善骨骼肌脂毒性胰岛素抵抗中的作用机制研究,主持,2016-2019,国家自然科学基金面上项目,58

  4. 高脂诱导骨骼肌胰岛素抵抗的分子调控机制研究,主持,2013-2016,国家自然科学基金面上项目,65

  5. 1型糖尿病优化监测与治疗方案的研究及关键新技术推广,分课题负责人,2017-2020,国家重点研发计划,165

  6. 肠道菌群与胰岛素抵抗的关系及其机制研究,主持,2016-2020,江苏省医学重点人才,100

  7. 基于糖尿病分级诊疗体系的标准化数据建设,主持,2016-2019,江苏省重点研发项目社会发展面上项目,80

  8. 2型糖尿病认知并发症的早期诊断和干预研究,主持,2020-2022,江苏省第十六批“六大人才高峰”高层次人才选拔培养资助项目,4

  9. ILC1/ILC2细胞免疫特性在脂肪组织纤维化发生发展中的作用及其机制研究,主持,2019-2020,江苏省第五期“333工程”科研项目,5

  10. 肥胖驱动2型糖尿病的病理生理机制研究,主持,中央高校基本科研业务费(国家自然科学杰出青年基金培育项目),10

获奖情况

  1. 糖尿病发病新机制和诊疗新技术,江苏省科学技术奖二等奖,第二完成人,江苏省人民政府,2018

  2. 中国2型糖尿病高血糖病理生理特点及干预新靶点,江苏医学科技奖一等奖,第一完成人,江苏省医学会,2018

  3. 2型糖尿病新的分子发病机制与临床诊治技术,江苏省科学技术奖二等奖,第二完成人,江苏省人民政府,2012

  4. 2型糖尿病新的分子发病机制与临床诊治技术,中华医学科技奖三等奖,第二完成人,中华医学会,2011

  5. 2型糖尿病基础与临床诊治技术研究,江苏医学科技奖二等奖,第二完成人,江苏省医学会,2011

  6. 2型糖尿病新的分子发病机制与临床诊治技术,南京市科学技术进步奖二等奖,第二完成人,南京市人民政府,2011

  7. 糖尿病心血管自主神经病变早期筛查技术及其临床应用,江苏省医学新技术引进奖一等奖,第一完成人,江苏省卫计委,2018

  8. 1H-MRS定量肝脏脂肪在评估降糖药物疗效中的临床应用, 江苏省卫生厅新技术引进奖一等奖,第一完成人,江苏省卫计委,2015

  9. 固醇调节原件结合蛋白-1c激活后通过抑制大鼠胰岛素受体底物-1转录介导骨骼肌胰岛素抵抗的作用,中国糖尿病十大研究最具影响力研究奖,第一完成人,中华医学会糖尿病学分会,2014

  10. Association of β-cell function and insulin sensitivity with fasting and 2-h plasma glucose in a large Chinese population,中国糖尿病十大研究最具影响力研究奖,第一完成人,中华医学会糖尿病学分会,2012

  11. 空腹血糖和负荷后2小时血糖对胰岛素分泌和胰岛素敏感性的不同影响,CGIS胰岛素分泌研究奖新星奖,第一完成人,中华医学会糖尿病学分会/内分泌学分会中国胰岛素分泌研究组,2011

  12. 早期胰岛素治疗对糖尿病大鼠骨骼肌胆固醇调节元件结合蛋白-1c表达的影响,中华糖尿病杂志优秀论文一等奖,第一完成人,中华糖尿病杂志,2011

  13. 南京市有突出贡献中青年专家,南京市人民政府,2017

  14. 南京市最具影响力留学人员,南京市人力资源和社会保障局,2021

  15. 中华医学会糖尿病学分会杰出青年科学研究奖,中华医学会糖尿病学分会青年委员会,2019

  16. 首届国家名医高峰论坛,国之名医青年新锐,人民网/健康时报社,2017