作者:2022-09-22浏览次数:2126

林兆宇

博士研究生导师简介

姓名

林兆宇

研究方向:

生理稳态的免疫和代谢调控

联系方式

025-58641511linzy@nju.edu.cn

学术兼职:

中国生物物理学会代谢分会青年理事


个人简介




林兆宇博士,2006-2012年在南京大学模式动物研究所攻读博士学位,师从高翔教授,并在美国圣路易斯华盛顿大学进行3年访问学者研究。回国后2012-2013年在南京大学化学化工学院进行博士后研究;2014年加入模式动物研究所任副研究员;2019年受聘为南京大学副教授,医药生物技术国家重点实验室研究员。










代表性论文[5年通讯作者和第一作者]



1.Zhao,M., K. Ren, X. Xiong, Y. Xin, Y. Zou, J.C. Maynard, A. Kim, A.P.Battist, N. Koneripalli, Y. Wang, Q. Chen, R. Xin, C. Yang, R.Huang, J. Yu, Z. Huang, Z. Zhang, H. Wang, D. Wang, Y. Xiao, O.C.Salgado, N.N. Jarjour, K.A. Hogquist, X.S. Revelo, A.L.Burlingame, X. Gao, J. von Moltke, Z. Lin*, and H.B.Ruan*, Epithelial STAT6 O-GlcNAcylation drives a concertedanti-helminth alarmin response dependent on tuft cell hyperplasiaand Gasdermin C. Immunity, 2022. 55(4): p. 623-638.e5.

2.Chen,Q., J. Zheng, D. Wang, Q. Liu, L. Kang, X. Gao*, and Z.Lin*, Nitrosonisoldipine is a selective inhibitor ofinflammatory caspases and protects against pyroptosis and relatedseptic shock. Eur J Immunol, 2021. 51(5): p. 1234-1245.

3.Zou,D., J. Pei, J. Lan, H. Sang, H. Chen, H. Yuan, D. Wu, Y. Zhang, Y.Wang, D. Wang, Y. Zou, D. Chen, J. Ren*, X. Gao*, and Z.Lin*, A SNP of bacterial blc disturbs gut lysophospholipidhomeostasis and induces inflammation through epithelial barrierdisruption. EBioMedicine, 2020. 52: p. 102652.

4.Wang,D., J. Zheng, Q. Hu, C. Zhao, Q. Chen, P. Shi, Q. Chen, Y. Zou, D.Zou, Q. Liu, J. Pei, X. Wu, X. Gao*, J. Ren*, and Z. Lin*,Magnesium protects against sepsis by blocking gasdermin DN-terminal-induced pyroptosis. Cell Death Differ, 2020.27(2): p. 466-481.

5.Sun,M., S. Zheng, X. Gao*, and Z. Lin*, The role ofimmune cells in obesogenic memory. Cell Mol Immunol, 2020.17(8): p. 884-886.

6.Wang,Y., P. Shi, Q. Chen, Z. Huang, D. Zou, J. Zhang, X. Gao*, and Z.Lin*, Mitochondrial ROS promote macrophage pyroptosis byinducing GSDMD oxidation. J Mol Cell Biol, 2019. 11(12): p.1069-1082.

7.Chen,Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z.Huang, J. Ren, Z. Lin*, and X. Gao*, GSDMB promotesnon-canonical pyroptosis by enhancing caspase-4 activity. J MolCell Biol, 2019. 11(6): p. 496-508.

8.Chen,Q., P. Shi, D. Wang, Q. Liu, X. Li, Y. Wang, D. Zou, Z. Huang, X.Gao*, and Z. Lin*, Epidermis-Activated Gasdermin-A3Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3Signaling. Am J Pathol, 2019. 189(5): p. 1041-1052.

9.Zou,J., B. Lai, M. Zheng, Q. Chen, S. Jiang, A. Song, Z. Huang, P.Shi, X. Tu, D. Wang, L. Lu, Z. Lin*, and X. Gao*,CD4+ T cells memorize obesity and promote weight regain. CellMol Immunol, 2018. 15(6): p. 630-639.

10.Lin,Z.*, F. Liu, P. Shi, A. Song, Z. Huang, D. Zou, Q. Chen,J. Li, and X. Gao, Fatty acid oxidation promotes reprogramming byenhancing oxidative phosphorylation and inhibiting protein kinaseC. Stem Cell Res Ther, 2018. 9(1): p. 47.












承担科研项目[项目负责人]



科技部,国家重点研发计划子课题,2018YFA0801101,建立小鼠发育代谢表型库-标准化突变小鼠品系建立与质控,2019-092024-08975万元














获奖情况