韩晓冬

文章来源:南京大学医学院发布时间:2018-12-25浏览次数:1112

博士研究生导师简介

姓名

韩晓冬

研究方向

1生殖与发育

2干细胞与组织再生

联系方式

电话025-83686497

Email: hanxd@nju.edu.cn

学术兼职:

教育部高等学校基础医学类专业教学指导委员会委员

江苏省高等学校医药教育研究会副理事长

江苏省解剖学会理事长

《中华男科学杂志》 编委

个人简介

南京大学医学院党委书记,博士,组织胚胎学教授,博士生导师。1984年毕业于南京大学生物系,获学士学位;1987年于南京大学生物系获硕士学位;2004年于南京大学生命科学院获博士学位。2001年,作为高级访问学者赴美国哈佛大学医学院Beth Israel Deaconess Medical Center开展合作研究。长期从生殖、干细胞与组织再生研究,主持并参与国家自然科学基金、国家973计划、教育部博士点基金、江苏省自然科学基金等研究项目,在国内外学术刊物共发表论文160余篇。主持文、理、医结合七年制临床医学专业人才培养模式的优化与创新组织胚胎学多媒体课程建设生殖生物学研究生核心课程建设等教学改革项目,参编生殖病理学组织胚胎学教材

代表性论文[5年通讯作者和第一作者]

  1. Hou Jiwei, Shi Jingyan, Chen Ling, Lv Zhongyang, Chen Xiang, Cao Honghui, Xiang Zou, and Han Xiaodong*. M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis. Cell Commun Signal. 2018 Nov 23;16(1):89. doi: 10.1186/s12964-018-0300-8.

  2. Pan Chun, Chen Yabing, Xu Tianchi, Wang Jing, Li Dongmei, and Han Xiaodong*. Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia.Environmental Pollution. Volume 242, Part B, November 2018, Pages 1535-1545.

  3. Wang Jing, Chen Yabing, Chen Zhangpeng, Xiang Zou, Ding Jie, and Han Xiaodong*. Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus. Ecotoxicol Environ Saf. 2018 Nov 15;163:391-399.

  4. Ding Jie, Wang Jing, Jin Haibo, Xia Tianjiao, Chen Yi, Wu Jiang, and Han Xiaodong*. Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice.Sci Total Environ. 2018 Dec 1;643:496-506.

  5. Chen Xiang, Shi Chaowen, Co Honghui, Chen Ling, Hou Jiwei, Xiang Zou, Hu Kebin, and Han Xiaodong*. The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis.Cell Death Dis. 2018 May 29;9(6):639.

  6. Chen Yabing, Wang Jing, Chen Xiang, Li Dongmei, and Han Xiaodong*. Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels.Aquat Toxicol. 2018 Jun;199:116-126.

  7. Hou Jiwei, Ma Tan, Cao Honghui, Chen Yabing, Wang Cong, Chen Xiang, Xiang Zou, and Han Xiaodong*. TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis.J Cell Physiol. 2018 Mar;233(3):2409-2419.

  8. Chen Yabing, Wang Jing, Pan Chun, Li Dongmei, and Han Xiaodong*. Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and molecular life sciences, Cell Mol Life Sci. 2018 Mar;75(6):1117-1132.

  9. Chen Yabing, Wang Jing, Zhang Qin, Xiang Zou, Li Dongmei,and Han Xiaodong*.Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis.Environmental Pollution 2017,229:964-975.

  10. Ding Jie, Wang Jing,Xiang Zou ,Diao Weiyi, Su Mengxi, Shi Weiwei, Wan Ting, and Han Xiaodong*. The organic anion transporting polypeptide 1a5 is a pivotal transporter for the uptake of microcystin-LR by gonadotropin-releasing hormone neurons. Aquat Toxicol. 2017,182:1-10.

  11. LiYan, Xu Jun, Shi Weiqing, Chen Cheng, Shao Yan, Zhu Limei, Lu Wei, and Han Xiaodong*.Mesenchymal stromal cell treatment prevents H9N2 avian influenza virusinduced acute lung injury in mice. Stem Cell Research & Therapy 2016,7:159.

  12. Wang Xueting, Ding Jie, Xiang Zou, Jiang Peipei, Du Jing,and Han Xiaodong*.Microcystin-LR causes sexual hormone disturbance in male rat by targeting gonadotropin-releasing hormone neurons.Toxicon.2016,123:45-55.

  13. Meng Xiannan, Zhang Ling, Chen Xiang, Xiang Zou, Li Dongmei, and Han Xiaodong*. miR-541 Contributes to Microcystin-LR-Induced Reproductive Toxicity through Regulating the Expression of p15 in Mice. Toxins (Basel). 2016,8,260.

  14. Chen Xiang, Shi Chaowen, Meng Xiannan, Zhang Kaijia, Li Xiaoyao, Wang Cong, Xiang Zou, Hu Kebin,and Han Xiaodong*.Inhibition ofWnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2. Experimental and Molecular Pathology. 2016,101: 22–30.

  15. Sun Fangfang,  Mao Peng, Wang Cong, Shi Chaowen, Nie Rongrong, Han Ningning, and Han Xiaodong*. Cytotoxic Effects of One-step Self-etching Dental Adhesiveson Human Periodontal Ligament Fibroblasts In Vitro. The Journal of Adhesive Dentistry 2016 ,18(2):99-109.

  16. Wang Cong, Gu Shen , Yin Xiaoqin, Yuan Mingming, Xiang Zou,Li Zutong, Cao Honghui, Meng Xiannan, Hu Kebin, and Han Xiaodong*.The toxic effects of microcystin-LR on mouse lungs and alveolar type II epithelial cells. Toxicon 2016,115:81-88.

  17. Shi Caoweng, Lv Tengfei, Xiang Zou, Sun Zhaowei, and Han Xiaodong*. Role of Wnt/β-catenin signaling in epithelial differentiation of lung resident mesenchymal stem cells. Journal of cellular biochemistry. 2015,116(8):1532-1539.

  18. Wu Jiang, Yuan Mingming, Song Yuefeng, Sun Feng, Han Xiaodong*. MC-LR Exposure Leads to Subfertility of Female Mice and Induces Oxidative Stress in Granulosa Cells.Toxins.2015, 7: 5212–5223.

  19.  Wang Cong, Dai Jinghong, Sun Zhaorui, Shi Chaowen, Cao Honghui, Chen Xiang, Gu Shen, Li Zutong, Qian Weiping, and Han Xiaodong*. Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Experimental Cell Research. 2015, 331(1): 115-122.

  20.  Shi Chaowen, Chen Xiang,  Sun Zhaorui, Xiang Zou, Qian Weiping, and Han Xiaodong*. Intracellular SERS probes based on -conjugated AuNSs for distinguishing between the differentiation of lung resident mesenchymal stem cells. Biomaterials. 2015, 58:10-25. 

  21. Zhou Yuan, Wang Hui, Wang Cong, Qiu Xuefeng, Benson Mikael, Yin Xiaoqin, Xiang Zou, Li Dongmei, Han Xiaodong*. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity. Toxicology and applied pharmacology 2015, 287:1-8.

  22. Wang Cong, Zhu Huiming, Sun Zhaorui, Xiang Zou, Ge Yuanyuan, Ni Can, Luo Zhaowen, Qian Weiping, and Han Xiaodong*. Inhibition of Wnt/β-catenin signaling promotes epithelial differentiation of mesenchymal stem cells and repairs bleomycin-induced lung injury. American journal of physiology. Cell physiology. 2014, 307(3):C234-44.

  23. Zhou Yuan, Xiang Zou, Li Dongmei,and Han Xiaodong*.Regulation of Microcystin-LR-Induced Toxicity in Mouse Spermatogonia by miR-96. Environmental Science and Technology. 2014,48:6383-6390.

  24. TuBowen, Li Juan, Guo Yueshuai, Guo Xuejiang, Lu Xiancai,and Han Xiaodong*. Compensation phenomena found in Acidithiobacillus ferrooxidans after starvation stress.Journal of Basic Microbiology. 2014, 54(6):598-606.

  25. Sun Zhaorui, Wang Cong , Shi Chaowen, Sun Fangfang, Xu Xiaomeng, Qian Weiping, Nie Shinan, Han Xiaodong*.Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells,contributing to pulmonary fibrosis.International Journal Of Molecular Medicine.2014,33:1097-1109.

  26. Wu Jiang, Shao Sijia, Zhou Fan, Wen Siyuan, Chen Fu, and HanXiaodong*. Reproductive toxicity on female mice induced bymicrocystin-LR. Environmental Toxicology and Pharmacology. 2014,37:1-6.

  27. Sun Zhaorui, Gong Xuemin, Zhu Huiming, Wang Cong, Xu Xiaomeng, Cui Di, Qian Weiping,and Han Xiaodong*.Inhibition of Wnt/b-CateninSignaling Promotes Engraftment of Mesenchymal Stem Cells to Repair Lung Injury. Journal of Cell Physiology. 2014,229:213-224.

  28. Wang Lihui, Wang Xueting, Geng Zhirong, Zhou Yuan, Chen Yu, Wu Jiang, Han Xiaodong*. Distribution of microcystin-LR to testis of maleSprague-Dawley rats. Ecotoxicology.2013,22:1555-1563.

  29. Chen Yu, Zhou Yuan, Wang Xueting, Qian Weiping, and Han Xiaodong*.Microcystin-LR induces autophagy and apoptosis in rat Sertoli cells in vitro.Toxicon. 2013,76:84-93.

  30. Zhou Yuan, Chen Yu, Yuan Mingming, Xiang Zou,and Han Xiaodong*.In vivo study on the effects of microcystin-LR on the apoptosis, proliferation and differentiation of rat testicular spermatogenic cells of male rats injected i.p.with toxins. The Journal of Toxicological Sciences.2013,38(5):661-670.

  31. Wang Xueting, Chen Yu, Zuo Xintong, Ding Naiqing, Zeng Huijuan, Xiang Zou, and Han Xiaodong*.Microcystin (-LR) induced testicular cell apoptosis via up-regulatingapoptosis-related genes in vivo.Food and Chemical Toxicology. 2013,60: 309–317.

承担科研项目[项目负责人]

  1. 国家自然科学基金项目(31870492):微囊藻毒素长期低剂量暴露引起小鼠学习记忆能力减退的分子机制探讨

  2. 国家自然科学基金项目(81570059):Hedgehog-Wnt信号通路参与特发性肺纤维化发病的分子机制探讨及疾病干预的基础研究

  3. 国家自然科学基金项目(31370524):微囊藻毒素下调雄性大鼠雄激素(睾酮)合成和分泌的机制研究

  4. 国家自然科学基金项目(30970530):微囊藻毒素低剂量长时间暴露对雄性大鼠生殖系统的影响及其机制研究

  5. 国家自然科学基金项目(81170054):调控Wnt信号通路对特发性肺纤维化发生发展影响的研究

  6. 国家自然科学基金项目(20577019):环境内分泌干扰物烷基酚生殖毒性风险评价标准的探索

  7. 高等学校博士学科点专项科研基金20130091110050):微囊藻毒素通过下丘脑-垂体-睾丸轴下调雄性激素合成及分泌的机制研究

  8. 江苏省自然科学基金(BK2011570):调控WNT信号通路对特发性纤维化发生发展影响的研究

  9. 江苏省自然科学基金(BK20151398):Hedgehog-Wnt信号通路参与特发性肺纤维化发病的分子机制探讨及疾病干预的基础研究

  10. 2017年度南京大学重点引智项目:Hedgehog-Wnt 信号通路参与特发性肺纤维化发病的分子机制探讨及疾病干预的基础研究

  11. 生物电子学国家重点实验室开放研究基金:应用表面增强拉曼光谱对肺干细胞向肺泡上皮细胞分化机制的研究

  12. 国家重点基础研究发展计划973”计划课题子项目2010CB945103):卵巢早衰的分子机制及其早期预测、诊断生物标记的研究

  13. 国家重点基础研究发展计划973”计划课题子项目(2007CB815603):微生物群落分解矿物的机理及其对生态环境的影响


获奖情况

2018年获南京大学本科实践教学优秀指导教师称号。

2017年获宝钢优秀教师奖称号。

2010年获南京大学我最喜爱的教师称号。