代表性成果：
Mao Y#, Jin Z#, Yang J, Xu D, Zhao L, Kiram A, Yin Y, Zhou D, Sun Z, Xiao L, Zhou Z, Yang L, Fu T, Xu Z, Jia Y, Chen X, Niu FN, Li X*, Zhu Z*, Gan Z*. Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is associated with bone metabolism in human and mouse.Sci Transl Med. 16(750): eadk9811.
Xiao L#, Yin Y#, Sun Z#, Liu J#, Jia Y, Yang L, Mao Y, Peng S, Xie Z, Fang L, Li J, Xie X* and Gan Z*.AMPK phosphorylation of FNIP1 (Ser220) controls mitochondrial function and muscle fuel utilization during exercise. Science Advances. 2024; 10(6): eadj2752.
Fu T #, Sun W#, Xue J#, Zhou Z#, Wang W, Guo Q, Chen X, Zhou D, Xu Z, Liu L, Xiao L, Mao Y, Yang L, Yin Y, Zhang XN, Wan Q, Lu B, Chen Y, Zhu MS, Philipp E. Scherer, Fang L, Piao HL, Shao M* and Gan Z*. Proteolytic rewiring of mitochondria by LONP1 directs cell identity switch of adipocytes. Nat Cell Biol. 2023; doi: 10.1038/s41556-023-01155-3.
Gan Z* and Shao M. Mitoprotease LONP1 controls white-to-beige adipocyte conversion via metabolic enzyme turnover. Nat Cell Biol. 2023; doi: 10.1038/s41556-023-01161-5.
Guo Q#, Xu Z#, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z*. Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.Science Advances. 2022; 8(30): eabo0340.
Yin Y, Xu D, Mao Y, Gan Z*. Comments on 'FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics'. J Mol Cell Biol. 2022; mjac033.
Yin Y#, Xu D#, Mao Y#, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z*. FNIP1 regulates white adipose tissue browning and systemic glucose homeostasis by shaping intracellular calcium dynamics.J Exp Med. 2022; 219(5): e20212491.
Xu Z#, Fu T#, Guo Q#, Zhou D, Sun W, Zhou Z, Chen X, Zhang Z, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu M, Fei W, Lu B, Gan Z*. Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. Nat Commun. 2022; 13(1):894.
He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z*and Liu Y*. IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay.J Clin Invest. 2021;131(17): e143737.
Xiao L#, Liu J#, Sun Z#, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T, Zhou W, Zhu Y, Chen XW, Li J, Chen S, Xie X, Gan Z*. AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1.PLoS Genet.2021; 17(3): e1009488.
Liu L#, Ding C#, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z*. Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest. 2020, 130(9):4710-4725.
Liu L#, Cai J#, Wang H#, Liang X#, Zhou Q#, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW*, Gan Z*.Coupling of COPII vesicle trafficking to nutrient availability by the IRE1a-XBP1s axis. Proc Natl Acad Sci USA. 2019; 116(24): 11776-11785.
Xu Z, Fu T, Guo Q, Sun W, Gan Z*. Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity.Pharmacol Res. 2018; 141:176-180.
Gan Z*, Fu T, Kelly DP*, Vega RB*. Skeletal muscle mitochondrial remodeling in exercise and diseases. Cell Research. 2018; 28(10): 969-980.
Fu T, Xu Z, Lin L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, Zhu M, Chen Q*, Gan Z*. Mitophagy directs muscle-adipose crosstalk to alleviate dietary obesity. Cell Reports. 2018; 23: 1357–1372.
Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega R, Zhu MS, Kelly DP, Gao X, Gan Z*. Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med.2016; 8(10):1212-1228. Cover story.
Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Lai L, Kong Y, Xie H, Yi F, Lai L, Vega R, Kelly DP, Smith SR, Gan Z*. Exercise inducible lactate dehydrogenase B regulates mitochondrial function in skeletal muscle. J. Biol. Chem.2016; 291(49):25306-25318.
Liu J, Liang X, Gan Z*. Transcriptional regulatory circuits controlling muscle fiber type switching. Sci China Life Sci.2015; 58(4):321-7.
Gan Z, Rumsey J, Hazen BC, Lai L, Leone TC, Vega RB, Xie H, Conley KE, Auwerx J, Smith SR, Olson EN, Kralli A, Kelly DP. Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest. 2013; 123(6):2564-75.
Gan Z, Burkart-Hartman EM, Han DH, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP. The nuclear receptor PPARb/d programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev. 2011; 25(24):2619-30.
Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W, Liu Y. RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells. J Biol Chem.2006; 281(44):33386-94.