作者:2017-07-03浏览次数:24283

侯亚义

博士研究生导师简介

姓名

侯亚义

研究方向:

细胞与分子免疫

联系方式

电话025-83686341

Emailyayihou@nju.edu.cn

学术兼职:曾为江苏省免疫学会常务理事等。

个人简介

侯亚义,南京大学教授/博导。获南京大学理学学士和硕士学位,日本东京大学博士学位。曾在东京大学从事博士后研究和美国密西根大学医学院作为访问学者。探索了炎症微环境中髓系免疫细胞调控肿瘤/自身免疫病发生发展的分子机制,发现髓源抑制性细胞(MDSCs)的异常扩增发生在狼疮的早期及其对T细胞等的调控作用;分析了树突状细胞(DCs)及间充质干细胞(MSCs)在自身免疫病中的作用,发现MSCs产生的外泌体与其母细胞对于缓解炎症性及免疫性疾病的作用类似;研究了肿瘤免疫逃逸机制,建立了一些靶向治疗肿瘤的方法;评价了一些中药成分对小鼠疾病模型的免疫调节及纤维化缓解的效果。主持和参与过国家自然科学基金重大研究计划项目、国家科技部重点研发计划课题、国家科技重大专项、国家科技支撑计划重大项目、江苏省卫生厅“兴卫工程”等项目。发表国内外论文280余篇,其中SCI收录论文220余篇;获授权国家专利5件。

代表性论文[3年通讯作者和第一作者]

  1. Li D, Lu L, Kong W, Xia X, Pan Y, Li J, Wang J, Wang T, Liang J, Dou H, Hou Y. C-type lectin receptor Dectin3 deficiency balances the accumulation and function of FoxO1-mediated LOX-1 + M-MDSCs in relieving lupus-like symptoms. Cell Death Dis. 2021 Sep 3;12(9):829.

  2. Shi G, Li D, Zhang D, Xu Y, Pan Y, Lu L, Li J, Xia X, Dou H, Hou Y. IRF-8/miR-451a regulates M-MDSC differentiation via the AMPK/mTOR signal pathway during lupus development. Cell Death Discov. 2021 Jul 16;7(1):179.

  3. Wang J, Li D, Pan Y, Li J, Jiang Q, Liu D, Hou Y. Interleukin-34 accelerates intrauterine adhesions progress related to CX3CR1+monocytes/macrophages. Eur J Immunol. 2021 Jun 17. doi: 10.1002/eji.202149174.

  4. Liu D, Li Q, Ding H, Zhao G, Wang Z, Cao C, Dai Y, Zheng M, Zhu X, Wu Q, Wang Y, Duan H, Tang H, Lu X, Hou Y, Hu Y. Placenta-derived IL-32β activates neutrophils to promote preeclampsia development. Cell Mol Immunol. 2021 Apr;18(4):979-991. 

  5. Li Y, Xu Y, Liu X, Yan X, Lin Y, Tan Q, Hou Y. mTOR inhibitor INK128 promotes wound healing by regulating MDSCs. Stem Cell Res Ther. 2021 Mar 10;12(1):170. 

  6. Zhang D, Song Y, Li D, Liu X, Pan Y, Ding L, Shi G, Wang Y, Ni Y, Hou Y. Cancer-associated fibroblasts promote tumor progression by lncRNA-mediated RUNX2/GDF10 signaling in oral squamous cell carcinoma. Mol Oncol. 2021 Mar 3. doi: 10.1002/1878-0261.12935.

  7. Sun Z, Qu J, Xia X, Pan Y, Liu X, Liang H, Dou H, Hou Y. 17β-Estradiol promotes LC3B-associated phagocytosis in trained immunity of female mice against sepsis. Int J Biol Sci. 2021 Jan 1;17(2):460-474.  

  8. Li J, Pan Y, Li D, Xia X, Jiang Q, Dou H, Hou Y. Urokinase-type plasminogen activator receptor is required for impairing toll-like receptor 7 signaling on macrophage efferocytosis in lupus. Mol Immunol. 2020 Nov;127: 38-45. 

  9. Sun Z, Pan Y, Qu J, Xu Y, Dou H, Hou Y. 17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB. Front Immunol. 2020 Jul 22; 11:1591.

  10. Li D, Pan Y, Xia X, Liang J, Liu F, Dou H, Hou Y. Bacteroides fragilis alleviates the symptoms of lupus nephritis via regulating CD1d and CD86 expressions in B cells. Eur J Pharmacol. 2020 Oct 5; 884:173421.

  11. Liu X, Xu Y, Li Y, Pan Y, Sun Z, Zhao S, Hou Y. Ganoderma lucidum fruiting body extracts inhibit colorectal cancer by inducing apoptosis, autophagy, and G0/G1 phase cell cycle arrest in vitro and in vivo.  Am J Transl Res. 2020 Jun 15; 12(6):2675-2684. 

  12. Yao G, Qi J, Liang J, Shi B, Chen W, Li W, Tang X, Wang D, Lu L, Chen W, Shi S, Hou Y, Sun L. Mesenchymal stem cell transplantation alleviates experimental Sjögren's syndrome through IFN-β/IL-27 signaling axis. Theranostics. 2019 Oct 21;9(26):8253-8265.

  13. Xu Y, Li Y, Liu X, Pan Y, Sun Z, Xue Y, Wang T, Dou H, Hou Y. SPIONs enhances IL-10-producing macrophages to relieve sepsis via Cav1-Notch1/HES1-mediated autophagy. Int J Nanomedicine. 2019 Aug 23; 14:6779-6797.

  14. Ji J, Ren L, Liu Y, Zheng M, Fang H, Xu Hui, He H, Zhang M, Wang X, Shan J, Hou Y. Elevated monocytic-myeloid derived suppressor cells positively correlate with infection frequency in children with RRTIs. Eur J Immunol. 2020 Oct 27. doi: 10.1002/eji.202048629. 

  15. Sun Z, Pan Y, Qu J, Xu Y, Dou H, Hou Y. 17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB. Front Immunol. 11:1591, 2020.

  16. Li D, Pan Y, Xia X, Liang J, Liu F, Dou H, Hou Y. Bacteroides fragilis alleviates the symptoms of lupus nephritis via regulating CD1d and CD86 expressions in B cells.Eur J Pharmacol. 884:173421, 2020.

  17. Liu X, Xu Y, Li Y, Pan Y, Sun Z, Zhao S, Hou Y. Ganoderma lucidum fruiting body extracts inhibit colorectal cancer by inducing apoptosis, autophagy, and G0/G1 phase cell cycle arrest in vitro and in vivo.Am J Transl Res. 12(6):2675-2684, 2020.

  18. Yao G, Qi J, Liang J, Shi B, Chen W, Li W, Tang X, Wang D, Lu L, Chen W, Shi S, Hou Y, Sun L. Mesenchymal stem cell transplantation alleviates experimental Sjögren's syndrome through IFN-β/IL-27 signaling axis. Theranostics. 2019 Oct 21;9(26):8253-8265.

  19. Xu Y, Li Y, Liu X, Pan Y, Sun Z, Xue Y, Wang T, Dou H, Hou Y. SPIONs enhances IL-10-producing macrophages to relieve sepsis via Cav1-Notch1/HES1-mediated autophagy. Int J Nanomedicine. 2019 Aug 23; 14:6779-6797.

  20. Ji J, Li P, Shen C, Dou H, Wang T, Shi L, Hou Y. MDSCs: friend or foe in systemic lupus erythematosus. Cell Mol Immunol. 2019 Dec;16(12):937-939.

  21. Li D, Qi J, Wang J, Pan Y, Li J, Xia X, Dou H, Hou Y. Protective effect of dihydroartemisinin in inhibiting senescence of myeloid-derived suppressor cells from lupus mice via Nrf2/HO-1 pathway. Free Radic Biol Med. 2019 Nov 1; 143:260-274.

  22. Li D, Shi G, Wang J, Zhang D, Pan Y, Dou H, Hou Y. Baicalein ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in myeloid-derived suppressor cells. Arthritis Res Ther. 2019 Apr 25;21(1):105.

  23. Shi G, Li D, Li X, Ren J, Xu J, Ding L, Dou H, Hou Y. mTOR inhibitor INK128attenuates systemic lupus erythematosus by regulating inflammation inducedCD11b (+) Gr1(+) cells. Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):1-13.

  24. Zhao J, Zhang Z, Xue Y, Wang G, Cheng Y, Pan Y, Zhao S, Hou Y. Anti-tumor macrophages activated by ferumoxytolcombined or surface-functionalized with the TLR3agonist poly (I:C) promote melanoma regression.  Theranostics, 2018; 8(22): 6307-6321.

  25. Pan Y, Wang J, Xue Y, Zhao J, Li D, Zhang S, Li K, Hou Y, Fan H. GSKJ4 Protects Mice Against Early Sepsis via Reducing Proinflammatory Factors and Up-Regulating MiR-146a. Front Immunol. 2018 Oct 2; 9:2272.

  26. Ren J, Ding L, Zhang D, Shi G, Xu Q, Shen S, Wang Y, Wang T, Hou Y.Carcinoma-associated fibroblasts promote the stemness and chemoresistance ofcolorectal cancer by transferring exosomal lncRNA H19. Theranostics. 2018 Jun24;8(14):3932-3948.

  27. Zhang D, Xu J, Ren J, Ding L, Shi G, Li D, Dou H, Hou Y. Myeloid-DerivedSuppressor Cells Induce Podocyte Injury Through Increasing Reactive OxygenSpecies in Lupus Nephritis. Front Immunol. 2018 Jun 25;9:1443.

  28. Ding L, Ren J, Zhang D, Li Y, Huang X, Hu Q, Wang H, Song Y, Ni Y, Hou Y. Anovel stromal lncRNA signature reprograms fibroblasts to promote the growth oforal squamous cell carcinoma via LncRNA-CAF/interleukin-33. Carcinogenesis. 2018 Mar 8;39(3):397-406.

  29. Ren J, Hou Y, Wang T. Roles of estrogens on myeloid-derived suppressor cellsin cancer and autoimmune diseases. Cell Mol Immunol. 2018 Jul;15(7):724-726.

  30. Fan H, Ren D, Hou Y. TLR7, a third signal for the robust generation ofspontaneous germinal center B cells in systemic lupus erythematosus. Cell MolImmunol. 2018 Mar;15(3):286-288.

目前承担科研项目[项目负责人]

  1. 狼疮病程中TLR7信号通过Dectin-3/CARD9轴调控MDSCs数量及功能的机制。(国家自然科学基金资助项目(31872732)2019.01- 2022.12)。主持

  2. 间充质干细胞通过调控髓系免疫细胞炎症参与子宫内膜重建的新技术研发。(江苏省重点研发计划(社会发展)临床前沿项目(BE2019706),2019.7-2022.6)。主持

  3. Toll样受体激动剂在卵巢癌分子靶向精准诊治中的技术开发与应用研究。(江苏省重点研发计划(社会发展)临床前沿项目(BE2019617),2019.7-2022.6)。合作参与


获奖情况

2005年度国家科学技术科技进步二等奖;

2007年度江苏省科技进步奖三等奖;

2014年度江苏省科技进步奖一等奖;

2016年获江苏省高校科学技术研究奖二等奖;

2017年度江苏省科技进步奖一等奖。