南京脑科医院老年精神科主任、科技处主任、教授、二级岗主任医师、博士生导师。江苏省“333工程”第二层次人才（2022）、江苏省卫健委医学重点人才（2011和2016）、南京市中青年突贡专家（2024）、南京市中青年拔尖人才（2019）和首届中国精神医学杰出青年医生（2019）。先后担任中华医学会、中国神经科学会和中国医师协会精神病学分会青年委员；江苏省医学会精神病学分会委员（精神分裂症学组和老年精神病学组组长）。关注精神分裂症、抑郁症和老年性痴呆神经影像特征、神经生物学和精神药理机制等。主持国自然科学基金6项、国家重点研发计划子课题1项、省科技厅社发重点和面上项目2项。发表SCI论文100余篇，其中第一/通讯作者79篇，包括Molecular Psychiatry、BMC Medicine、Schizophrenia Bulletin（4篇）、Brain Behav Immun（3篇）和Brain Stimulation等，发明专利授权1项。荣获江苏省科学技术奖三等奖（2022）、江苏省医学科技奖二等奖（2022）、江苏省医学新技术引进奖一等奖（2011）/二等奖（2019、2022），参与获得教育部奖（自然科学奖）一等奖（2010）。

中华医学会精神医学分会老年精神病学组委员

中国老年医学学会精神医学与心理健康分会委员

江苏省医学会精神医学分会委员

江苏省医学会精神医学分会精神分裂症学组组长

江苏省医学会精神医学分会老年精神病学组组长

南京医学会精神医学分会副主任委员

1. Shao M#, Zhu T#, Hu X#, Fang X, Pan X, Wen L, Dai P, Amdanee N, Zhang L, Xu Y*, Zhang X*. Clinical hallmarks and peripheral immune factors associated with antipsychotic-induced constipation in schizophrenia. Ther Adv Psychopharmacol. 2026 Mar 26;16:20451253261432764. 中科院2区

2. Jiang C#, Ge X#, Wu C, Zhang X*, Fang X*. Accelerated aging in psychiatric disorders: evidence from epigenetic clocks. Prog Neuropsychopharmacol Biol Psychiatry. 2026 Feb 4;145:111632. 中科院2区

3. Li Y#, Ling Y#, Li Y#, Fang X*, Zhang X*. Effect of electroconvulsive therapy on neural oscillations in schizophrenia: A magnetoencephalography resting-state study. Brain Stimul. 2026 Feb 28;19(2):103062. IF2024:8.4 中科院1区top

4. Li Y#, Wang G#, Fang X#, Ling Y, Zhou C, Fang J, Cai R, Hu Y, Wu C, Zhang S, Iqbal AZ, Wang Y*, Su KP*, Zhang X*. Metabolomic signatures of electroconvulsive therapy in schizophrenia: Mitochondrial energy metabolism and inflammation as therapeutic targets. Brain Behav Immun. 2026 Mar;133:106235. 中科院1区top

5. Hu Y#, Wang Z#, Fang J#, Zhang S#, Li Y, Wu C, Wang Y, Ling Y, Cai R, Xu Y, Fang X, Zhou C, Xu D, Liu M, Zhang Z*, Zhang X*. Selective magnetic stimulation downregulates the GABAA receptor ε subunit in the left prelimbic cortex to alleviate schizophrenia-like behaviors in mice. Molecular Psychiatry. Mol Psychiatry. 2026 Jan;31(1):383-395. IF2024:10.1 中科院1区top

6. Fang X#, Yu H#, Wu C#, Tan J, Sun F, Qian N, Zhou H, Zhou J*, Zhang X*. A retrospective and comprehensive analysis of excess life-years lost, mortality risk, and cause of death among severe mental illness in China. BMC Medicine. 2025 Oct 21;23(1):571. doi: 10.1186/s12916-025-04380-9. PMID: 41121045; PMCID: PMC12538965. IF2024:8.3 中科院1区top

7. Gao J#, Jia J#, Jiang Q#, Yang P, Li J, Zhang X, Zhang X*, Tang X*. Subcortical volume alteration and correlation with social function under chlorpromazine versus clozapine treatment in schizophrenia. BMC Psychiatry. 2025 Sep 30;25(1):887. 中科院2区

8. Wang D#, Wang W#, Liao Y#, Zhang H, Lu Y, Liu H, Zhang Y, Yuan L, Wu M, Gao Y*, Fang X*, Zhang X*. Interpersonal sensitivity as a central hub: a network analysis of childhood trauma and psychological symptoms in adolescents with major depressive disorder. Eur Arch Psychiatry Clin Neurosci. 2025 Sep 27. doi: 10.1007/s00406-025-02124-7. 中科院2区

9. Gao C#, Li G#, Zhang X#, Lu T, Wang Z, Zhou C, Chen G, Ma D, Wang W, Fang X, Guo S*, Huang C*, Zhou C*. Effects of theta burst stimulation on cognitive function and characteristics of blood oxygen alterations based on near-infrared spectroscopy in chronic schizophrenia. BMC Psychiatry. 2025 Aug 12;25(1):784. 8.中科院2区

10. Fang J#, Hu Y#, Li Y, Wu C, Lv Y, Tang X, Fang X, Zhang X*, Zhou C*. Left amygdala alterations mediate the effects of negative symptoms on social dysfunction in schizophrenia. Schizophrenia (Heidelb). 2025 Jul 29;11(1):107. 中科院2区

11. Wu C#, Tong S#, You Y#, Li Y, Cai R, Fang J, Fang X*, Zhang X*. The causal and mediated relationships between major depressive disorder (MDD), post-traumatic stress disorder (PTSD), anxiety disorders and premature mortality: Evidence from genome-wide association study. Journal of Affective Disorders. 2025 Jun 30;390:119781. 中科院2区

12. Gao J#, Yu D#, Yin M, Li J, Zhang X, Tang X*, Zhang X*. Distinct white matter abnormalities and cognitive impairments in deficit schizophrenia: A cross-sectional diffusion tensor imaging study. J Psychiatr Res. 2025 Jan;181:381-390. 中科院2区

13. Ni L, Zhu Y, Lv L, Zhang R, Xie S*, Zhang X*. Peripheral blood miR-16-5p as a potential biomarker for distinguishing unmedicated bipolar disorder type II from major depressive disorder. Journal of Affective Disorders. 2025 Aug 1; 382: 453-461. 中科院2区

14. Chen J#, Duan W#, Liu P#, Long C, Li A, Zhang X*, Zuo X*. Schizophrenia, bipolar disorder and major depressive disorder are probably not risk factors for cardiovascular disease: A Mendelian randomized study. J Affect Disord. 2025 Feb 19;377:184-196. 中科院2区

15. Tong S#, Wang R#, Li H#, Tong Z, Geng D, Zhang X*, Ren C*. Executive dysfunction in Parkinson's disease: From neurochemistry to circuits, genetics and neuroimaging. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 27;137:111272. 中科院2区

16. Pan B#, Li X#, Weng J#, Xu X, Yu P, Zhao Y, Yu D, Zhang X*, Tang X*. Identifying periphery biomarkers of first-episode drug-naïve patients with schizophrenia using machine-learning-based strategies. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Feb 25:111302. 中科院2区

17. Zhou C#, Zhang R#, Ding M, Duan W, Fang J, Tang X, Qu Q*, Zhang X*. Progressive structural alterations associated with negative symptoms in schizophrenia: A causal structural covariance network analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Dec 26:111236. 中科院2区

18. Gao C#, Li G#, Wang Z#, Jiang Q, He R, Sun J, You Y, Zhu Y, Zhao J, Zhang X*, Zhou C*. The therapeutic effects of theta burst stimulation on negative symptoms in chronic schizophrenia using functional near-infrared spectroscopy. J Psychiatr Res. 2024 Dec 7;181:484-491. 中科院2区

19. Fang J#, Lv Y#, Xie Y#, Tang X, Zhang X, Wang X, Yu M, Zhou C*, Qin W*, Zhang X*. Polygenic effects on brain functional endophenotype for deficit and non-deficit schizophrenia. Schizophrenia (Heidelb). 2024 Feb 16;10(1):18. 中科院2区

20. Fang J#, Cai R#, Hu Y#, Wang Y, Ling Y, Lv Y, Fang X, Zhang X*, Zhou C*. Aberrant brain functional connectivity mediates the effects of negative symptoms on cognitive function in schizophrenia: A structural equation model. J Psychiatr Res. 2024 Sep;177:109-117. 中科院2区

21. Zhou C, Tang X, Yu M, Zhang H, Zhang X, Gao J, Zhang X*, Chen J*. Convergent and divergent genes expression profiles associated with brain-wide functional connectome dysfunction in deficit and non-deficit schizophrenia. Transl Psychiatry. 2024 Feb 27;14(1):124. 中科院1区top

22. Wang Y#, Wang G#, Gong M#, Yang Y, Ling Y, Fang X, Zhu T, Wang Z, Zhang X*, Zhang C*. Systemic inflammatory biomarkers in Schizophrenia are changed by ECT administration and related to the treatment efficacy. BMC Psychiatry. 2024 Jan 17;24(1):53. 中科院2区

23. Wang Y#, Zhang X*. The role of immune inflammation in electroconvulsive therapy for schizophrenia: Treatment mechanism, and relationship with clinical efficacy: Immune-inflammation in ECT for schizophrenia. Psychiatry Res. 2024 Feb;332:115708. 中科院2区

24. Chen J#, Amdanee N#, Zuo X, Wang Y, Gong M, Yang Y, Li H, Zhang X*, Zhang C*. Biomarkers of bipolar disorder based on metabolomics: A systematic review. J Affect Disord. 2024 Jan 12;350:492-503. 中科院2区

25. Ye B#, Wu Y#, Cao M#, Xu C, Zhou C*, Zhang X*. Altered patterns of dynamic functional connectivity of brain networks in deficit and non-deficit schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2024 Apr 25. doi: 10.1007/s00406-024-01803-1. 中科院2区

26. Gao J#, Jiang R#, Tang X, Chen J, Yu M, Zhou C, Wang X, Zhang H, Huang C, Yang Y, Zhang X, Cui Z, Zhang X#. A neuromarker for deficit syndrome in schizophrenia from a combination of structural and functional magnetic resonance imaging. CNS Neurosci Ther. 2023 Jun 8. doi: 10.1111/cns.14297. 中科院1区

27. Wang Y#, Fang X#, Wang G#, Tang W, Liu S, Yang Y, Chen J, Ling Y, Zhou C, Zhang X*, Zhang C*, Su KP*. The association between inflammation and kynurenine pathway metabolites in electroconvulsive therapy for schizophrenia: Implications for clinical efficacy. Brain Behav Immun. 2023 Jun 21;113:1-11. 中科院2区

28. Amdanee N#, Shao M#, Hu X#, Fang X, Zhou C, Chen J, Ridwan Chattun M, Wen L, Pan X, Zhang X*, Xu Y*. Serum Metabolic Profile in Schizophrenia Patients With Antipsychotic-Induced Constipation and Its relationship With Gut Microbiome. Schizophr Bull. 2023 May 3;49(3):646-658. 中科院1区top

29. Guan C#, Amdanee N#, Liao W#, Zhou C, Wu X, Zhang X*, Zhang C*. Altered intrinsic default mode network functional connectivity in patients with remitted geriatric depression and amnestic mild cognitive impairment. Int Psychogeriatr. 2022 Aug;34(8):703-714. 中科院1区top

30. Xu Y#, Shao M#, Fang X#, Tang W, Zhou C, Hu X, Zhang X*, Su KP*. Antipsychotic-induced gastrointestinal hypomotility and the alteration in gut microbiota in patients with schizophrenia. Brain Behav Immun. 2022 Jan;99:119-129. 中科院1区top 

1. 精神分裂症阴性症状经颅磁刺激治疗效应遗传影像学机器学习预测模型研究（项目编号：82371510），国家自然科学基金面上项目，2024.01-2027.12，49万元，主持

2. 基于机器学习的精神分裂症阴性症状转归预测关键技术研究及应用（项目编号：BE2023668），江苏省科技厅社会发展重点项目，2023.07-2026.06，400万元，主持

3. 基于阴性症状两因子理论构建精神分裂症转归预测的多维度机器学习模型（项目编号：81971255），国家自然科学基金面上项目，2020.01-2023.12，55万元，主持

4. 基于阴性症状两因子理论构建精神分裂症功能结局的机器学习预测模型（项目编号：BE2019610），江苏省科技厅社会发展面上项目，2019.07-2022.06，50万元，主持

5. 精神分裂症早期个体化诊疗生物学标记体系研究（项目编号：2018YFC1314303），科技部“重大慢性非传染性疾病防控研究”重点专项，2018.01-2021.12，195万元，主持

6. 缺陷型精神分裂症脑连接组学与谷氨酸系统关联研究（项目编号：81571314），国家自然科学基金面上项目，2016.01-2019.12，57万元，主持

7. 慢性缺陷型精神分裂症外周免疫系统分子遗传与表观遗传特征研究（项目编号：81371474），国家自然科学基金面上项目，2014.01-2017.12，70万元，主持

8. 老年抑郁症和轻度认知功能损害神经环路基础及其与APOE基因交互作用研究（项目编号：91132727），国家自然科学基金重大研究计划培育项目，2012.01-2014.12，80万元，主持

9. CREB-BDNF信号通路表观修饰与SSRI类药物抗抑郁效应关系研究（项目编号：30900482），国家自然科学基金面上项目，2010.01-2012.12，20万元，主持

荣获江苏省科学技术奖三等奖（2022）、江苏省医学科技奖二等奖（2022）、江苏省医学新技术引进奖一等奖（2011）/二等奖（2019、2022），参与获得教育部奖（自然科学奖）一等奖（2010）。