张爱华
电话:18951769017邮箱:zhaihua@njmu.edu.cn 地址:研究方向:

儿童肾脏病

  • 个人简介
  • 学术兼职
  • 代表性论文
  • 承担科研项目
  • 获奖情况

张爱华,二级教授、主任医师、博士生导师,国家杰出青年科学基金获得者,国家万人计划科技创新领军人才,享受国务院政府特殊津贴专家,科技部中青年科技创新领军人才,江苏省特聘教授,江苏省“333工程第一层次培养对象,南京医科大学附属儿童医院副院长/肾脏科学科带头人,江苏省儿童重大疾病研究重点实验室主任,南京医科大学儿科研究所所长。

一直致力于儿童慢性肾脏病和急性肾损伤的发病机制与早期干预的研究,主持国家杰出青年科学基金1项、国家自然科学基金重点项目2项、国家重点研发计划重大专项课题2项等国家和部省级课题,共计20余项。在Science Translational MedicinePNAS、肾脏病领域顶级期刊J Am Soc NephrolKidney Int以及JBC等发表SCI收录论文160余篇,累计影响因子600余分。获批国家发明专利8项,相关研究成果先后获得教育部自然科学一等奖、中国妇幼健康科学技术奖自然科学奖二等奖、江苏省卫生计生委医学新技术引进奖一等奖、江苏省科学技术二等奖和三等奖以及中华肾脏病青年研究者奖等。


中华医学会儿科分会肾脏学组组长、江苏省医学会罕见病分会首届主任委员/儿科分会副主任委员,同时兼任《Kidney Disease》杂志副主编;《American Journal of Physiology Renal》、《World Journal of Pediatrics》等期刊杂志编委

1.Nuclear receptor PXR targets AKR1B7 to protect mitochondrial   metabolism and renal function in AKI. Sci   Transl Med.2020 May 13;12(543):eaay7591. doi: 10.1126/ scitranslmed.aay7591.(通讯作者, IF=17.16

2.Response to   comment on ”Nuclear receptor PXR targets AKR1B7 to protect mitochondrial   metabolism and renal function in AKI”. Sci Transl Med. 2021 May 12;13(593):eabf9849(通讯作者,IF=17.992

3.Dimethyl   fumarate prevents ferroptosis to attenuate acute kidney injury by acting on   NRF2. Clin Transl Med. 2021 Apr;11(4):e382.    doi: 10.1002/ctm2.382. (通讯作者,IF=11.492

4.Reduced Lon protease 1 expression in podocytes contributes to the   pathogenesis of podocytopathy.Kidney Int.   2021 Apr;99(4):854-869.(通讯作者,IF=10.612

5.MicroRNA-214   promotes chronic kidney disease by disrupting mitochondrial oxidative   phosphorylation. Kidney Int. 2019   Jun;95(6):1389-1404. (通讯作者,IF=8.945

6.Functional   Characterization of PHEX Gene Variants in Children With X-Linked   Hypophosphatemic Rickets Shows No Evidence of Genotype-Phenotype Correlation.   J Bone Miner Res. 2020 Apr 24. doi:   10.1002/jbmr.4035.(通讯作者,IF=6.741

7.Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the   Pathogenesis of Cardiovascular Disease.Front Immunol.   2022 May 26;13:893204.(通讯作者,IF= 7.5607

8.Isoliquiritin Ameliorates Cisplatin-Induced Renal Proximal Tubular   Cell Injury by Antagonizing Apoptosis, Oxidative Stress and Inflammation.Front Med (Lausanne). 2022 Mar 30;9:873739. (通讯作者,IF= 5.0929

9.Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase   Inhibitors in Treating Nonanemic Diseases.Front Pharmacol. 2022 Feb 24;13:837249.(通讯作者,IF=5.8106

10.Maintaining   homeostasis of mitochondria and endoplasmic reticulum with NSC228155   alleviates cisplatin-induced acute kidney injury.Free Radic Biol Med. 2022   Mar;181:270-287. doi: 10.1016/j.freeradbiomed.2022.02.003.通讯作者,IF=7.3762

11.mPGES-2   blockade antagonizes β-cell senescence to ameliorate diabetes by acting on   NR4A1.Nat Metab. 2022 Feb;4(2):269-283.(通讯作者,IF=13.5102

12.Computational Systems Pharmacology, Molecular Docking and   Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the   Treatment of Glomerulonephritis.J Inflamm Res. 2021 Dec 16;14:6939-6958.通讯作者,IF=6.922

13.Gasdermin E Deletion Attenuates Ureteral Obstruction- and 5/6   Nephrectomy-Induced Renal Fibrosis and Kidney Dysfunction.Front Cell Dev   Biol. 2021 Oct 21;9:754134.(通讯作者,IF=6.684

14.Roxadustat prevents Ang II hypertension by targeting angiotensin   receptors and eNOS.JCI Insight. 2021 Sep 22;6(18):e133690.(通讯作者,IF=8.315

15.SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by   Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome   Activation.Kidney Dis (Basel). 2021 Jul;7(4):293-305.通讯作者,IF=3.222

16.Blocking AURKA   with MK-5108 attenuates renal fibrosis in chronic kidney disease. BiochimBiophys Acta Mol Basis Dis. 2021 Nov 1;1867(11):166227.通讯作者,IF=5.1867

17. Anti-anemia drug FG4592 retards the AKI to CKD transition by   improving vascular regeneration and anti-oxidative capability. Clin Sci   (Lond). 2021 Jul13:CS20210100. doi: 10.1042/CS20210100. Epub ahead of print. (通讯作者,IF=6.124

18.Clinical and Functional Characterization of Novel INSR Variants in   Two Families With Severe Insulin Resistance Syndrome. Front Endocrinol   (Lausanne). 2021 Apr 29;12:606964. doi:10.3389/fendo.2021.606964. (通讯作者,IF=5.555

19.Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced   Acute Liver Injury. Front Pharmacol. 2021 Apr 23;12:626166. doi:   10.3389/fphar.2021.626166.(通讯作者,IF=5.8

20.The novel STING antagonist H151 ameliorates cisplatin-induced   acute kidney injury and mitochondrial dysfunction. Am J Physiol Renal   Physiol. 2021 Apr1; 320(4):F608-F616. doi: 10.1152/ajprenal.00554.2020. Epub   2021 Feb 22. (通讯作者,IF=3.377

21. Multi-centre study of the clinical features and gene variant   spectrum of Gitelman syndrome in Chinese children. Clin Genet. 2021 Apr;   99(4):558-564. doi:10.1111/cge.13913. Epub 2021 Feb (通讯作者,IF=4.438

22. Gasdermin E deficiency attenuates acute kidney injury by   inhibiting pyroptosis and inflammation. Cell Death Dis. 2021 Feb 1;   12(2):139. doi: 10.1038/s41419-021-03431-2. (通讯作者,IF=8.469

23.Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by   Inhibiting the TGF-β1-Smad2/3 Signaling Pathway. Front Med (Lausanne). 2021   Jan21; 7:626140. doi: 10.3389/fmed.2020.626140.(通讯作者,IF=5.091

24.Celastrolinhibits intestinal lipid absorption by reprofiling the   gut microbiota to attenuate high-fat diet-induced obesity. iScience. 2021 Jan   20;24(2):102077.doi: 10.1016/j.isci.2021.102077. (通讯作者, IF=5.458

25.Targeting microsomal prostaglandin E synthase 1 to develop drugs   treating the inflammatory diseases. Am J Transl Res. 2021 Jan15;   13(1):391-419. (通讯作者,IF=4.06

26.The emerging role of MEIS1 in cell proliferation and   differentiation. Am J Physiol Cell Physiol. 2020 Dec 9. doi:   10.1152/ajpcell.00422.2020. Online ahead of print.(通讯作者,IF=3.452

27.Mitochondrial Dysfunction and the AKI to CKD Transition. Am J   Physiol Renal Physiol. 2020 Oct 19. doi: 10.1152/ajprenal.00285.2020.   Online ahead of print.(通讯作者,IF=3.323

28.miR-214   Protects Against Uric Acid-Induced Endothelial Cell Apoptosis. Front Med   (Lausanne). 2020 Aug 5;7:411. doi: 10.3389/fmed.2020.00411. eCollection   2020. (通讯作者,IF= 5.093

28.LIM-Nebulette   Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin   Filaments. J Am Soc Nephrol. 2020 Oct;31(10):2372-2391.(通讯作者,IF=10.121

29.New   Criterion to Evaluate Acute-on-Chronic Kidney Injury Based on the Creatinine   Reference Change. Am J Nephrol.   2020 Apr 29:1-10. doi: 10.1159/000506664. Online ahead of print.(通讯作者,IF=3.745

30.Inhibition of ROCK2 alleviates renal fibrosis and the   metabolic disorders in the proximal tubular epithelial cells. Clin Sci (Lond). 2020 Jun   26;134(12):1357-1376.(通讯作者,IF=5.127

31.   Chinese Society of Pediatric Nephrology and Chinese Medical Doctor   Association of Pediatric Nephrology. Consensus recommendations for the care   of children receiving chronic dialysis in association with the COVID-19   epidemic. Pediatr Nephrol. 2020 Apr   24. doi: 10.1007/s00467-020-04555-x. (通讯作者,IF=3.714

32.IPDN-China   investigators. IPDN-China promotes the development of pediatric dialysis in   China. Pediatr Nephrol. 2020 Nov;35(11):2163-2171. (通讯作者,IF=3.714

33.Splicing   Characterization of CLCNKB Variants in Four Patients With Type III   Bartter Syndrome.Front Genet. 2020   Feb 21;11:81. doi: 10.3389/fgene.2020.00081. eCollection 2020.(通讯作者,IF=3.517

34.Trehalose   attenuates renal ischemia-reperfusion injury by enhancing autophagy and   inhibiting oxidative stress and inflammation.Am J Physiol Renal Physiol. 2020 Feb 18. doi:   10.1152/ajprenal.00568.2019. [Epub ahead of print](通讯作则,IF=3.323

35.Ursodeoxycholic   acid protects against cisplatin-induced acute kidney injury and mitochondrial   dysfunction through acting on ALDH1L2.Free   Radic Biol Med. 2020 Jan 28. pii: S0891-5849(19)31732-0. doi:   10.1016/j.freeradbiomed.2020.01.182. (通讯作者, IF=5.657

36.Inhibition of   PDE4/PDE4B improves renal function and ameliorates inflammation in   cisplatin-induced acute kidney injury.Am   J Physiol Renal Physiol. 2020 Mar 1;318(3):F576-F588(通讯作者,IF=3.323

37.MicroRNA-214   targets COX-2 to antagonize indoxyl sulfate (IS)-induced endothelial cell   apoptosis.Apoptosis. 2020   Feb;25(1-2):92-104. doi: 10.1007/s10495-019-01582-4.(通讯作者,IF=4.6767

38.Activation of   GSDMD contributes to acute kidney injury induced by cisplatin.Am J Physiol Renal Physiol. 2020 Jan   1;318(1):F96-F106. doi: 10.1152/ajprenal.00351.2019. (通讯作者,IF=3.323

39.Multicenter   study of the clinical features and mutation gene spectrum of Chinese children   with Dent disease.  Clin Genet. 2020 Mar;97(3):407-417.   doi: 10.1111/cge.13663.(通讯作者,IF=4.104

40.BMP1   inhibitor UK-383,367 attenuates renal fibrosis and inflammation in CKD.Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1430-F1438. doi:   10.1152/ajprenal.00230.2019.(通讯作者,IF=3.323

41.Rotenone   protects against β-cell apoptosis and attenuates type 1 diabetes mellitus.Apoptosis. 2019 Dec;24(11-12):879-891. doi:   10.1007/s10495-019-01566-4.(通讯作者,IF=4.6767

42.Genetic   spectrum of renal disease for 1001 Chinese children based on a multicenter   registration system. Clin Genet.   2019 Jul 22. doi: 10.1111/cge.13606. [Epub ahead of print] (通讯作者,IF=4.104

43.Celastrol   attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3   inflammasome activation. Cell Death   Discov. 2019 Jul 5;5:114. doi: 10.1038/s41420-019-0196-0.(通讯作者,IF=4.1137

44. Mitochondrial   activity contributes to impaired renal metabolic homeostasis and renal   pathology in STZ-induced diabetic mice. Am J Physiol Renal Physiol. 2019 Jul   3. doi: 10.1152/ajprenal.00076.2019. [Epub ahead of print](通讯作者,IF=3.191

45.Inhibition of   mitochondrial activity ameliorates atherosclerosis in ApoE-/- mice via   suppressing vascular smooth cell activation and macrophage foam cell   formation. J Cell Biochem. 2019 May   26. doi: 10.1002/jcb.29042. [Epub ahead of print] (通讯作者,IF=3.448

46.Inhibition of   the mitochondrial complex-1 protects against carbon tetrachloride-induced   acute liver injury. Biomed   Pharmacother. 2019 Jul;115:108948. (通讯作者,IF=3.743

47.Adenosine   kinase inhibition protects against cisplatin-induced nephrotoxicity. Am J Physiol Renal Physiol. 2019 Jul   1;317(1):F107-F115. (通讯作者,IF=3.191

48.Understanding   kidney injury molecule 1: a novel immune factor in kidney pathophysiology. Am J Transl Res. 2019 Mar   15;11(3):1219-1229. (通讯作者,IF=3.375

49.Acute Kidney   Injury among Hospitalized Children in China. Clin J Am Soc Nephrol.2018 Dec 7;13(12):1791-1800.(通讯作者,IF=6.243

50.Inhibition of   mitochondrial complex I activity attenuates neointimal hyperplasia by   inhibiting smooth muscle cell proliferation and migration. Chem Biol Interact. 2019 May   1;304:73-82. (通讯作者,IF=3.407

51.Inhibition of   mitochondrial complex I by rotenone protects against acetaminophen-induced   liver injury. Am J Transl Res. 2019   Jan 15;11(1):188-198. (通讯作者, IF=3.266

52.Estrogen-related   receptor-α mediates puromycin aminonucleoside-induced mesangial cell   apoptosis and inflammatory injury. Am J   Physiol Renal Physiol. 2019;316(5):F906-F913. (通讯作者,IF=3.126

53.NLRP3   deletion inhibits inflammation-driven mouse lung tumorigenesis induced by   benzo(a)pyrene and lipopolysaccharide. Respir   Res. 2019 Jan 29;20(1):20. doi: 10.1186/s12931-019-0983-4.(通讯作者,IF=3.294


1.      Meis1:调控线粒体稳态阻断肾脏纤维化的新机制(82090022),国家自然科学基金重大项目课题,2021.01-2025.12430万元,主持

2.      WWP2介导的泛素化修饰:免疫性肾小球疾病炎性损伤的新机制(81830020),2019.1-2023.12,国家自然科学基金重点项目,294万元,主持

3.      高胆固醇及致病基因对心血管发育的影响及调控机制(2019YFA0802702),国家重点研发计划, 2019.12-2024.11104.85万元,主持

4.      儿童ANCA相关性肾炎规范化诊疗策略研究(BE2021607),江苏省社会发展——临床前沿技术,2021.7-2024.6200万元,主持

5.      儿童慢性肾脏病的基础与临床研究,江苏省高水平大学建设专项经费,2019-2024500万元,主持

6.      线粒体稳态调控:肾脏纤维化干预的新靶标(81530023),国家自然科学基金重点项目,2016.01-2020.12328.8万元,主持

7.      免疫性肾病的干预靶点研究(2016YFC0906103),国家重点研发计划重大专项(The National Key Research and Development   Program of China),2016.07-2020.12320万元,主持

8.      儿童慢性肾脏病的基础与临床研究(JCRCB2016008),江苏省医学杰出人才基金,2016-2020150万元,主持

9.      儿童过敏性紫癜和紫癜性肾炎的规范化诊治(ZDX16009),南京市十三五医学科技创新重大项目,2017.01-2019.1280万元,主持

10.  江苏省特聘教授,江苏省政府,2016.01-2018.12200万元,主持

11.  慢性肾脏病(81325004),国家杰出青年科学基金,2014.01-2017.12320万元,主持

12.  儿童紫癜性肾炎规范性诊治策略研究(BL2014007),江苏省临床医学科技重大专项,2014.07.01-2017.06.30200万元,主持

13.  miR-30e通过抑制SIRT1/PGC-1α信号通路诱导线粒体功能障碍和足细胞损伤(81270797),国家自然科学基金面上项目,2013-201670万元,主持


1. Minigene技术在儿童罕见遗传病基因诊断中的应用,江苏省卫生计生委2021年度医学新技术引进奖一等奖,2021年,第一完成人

2. 二代测序技术在儿童罕见遗传性疾病诊断中的应用,江苏省医学新技术引进奖一等奖,2018年(排名第一)

3. 氧化应激在儿童慢性肾脏病发病机制及早期干预中作用的研究,全国妇幼健康科学技术奖自然科学奖二等奖,2017年(排名第一)

4. 儿童慢性肾脏病进展的关键机制与早期诊治研究,江苏医学科技奖二等奖,2016年(排名第二)

5. 氧化应激在慢性肾脏病的发生与进展中的作用及干预研究,江苏省科学技术奖二等奖,2014年(排名第一)

6. 慢性肾脏病进展关键机制及其诊断标志物研究,教育部自然科学奖一等奖,2014年(排名第二)

7. 氧化应激在小儿慢性肾脏病的发病机制及早期干预中的作用,宋庆龄儿科医学奖,2013年(排名第二)

8. 肾脏纤维化的细胞分子机制及其干预研究,江苏省科技进步三等奖,2010年。(排名第一)

9. JNK信号通路活化在小儿慢性肾脏病发病机制和早期诊断中的作用,江苏省医学科技奖二等奖,2010年。(排名第一)

10. 氧化应激介导的MAPK信号通路活化在小儿慢性肾脏病中作用的研究,江苏省科技进步三等奖,2009年。(排名第二