王琛博士
主任医师、教授
电话:17715187003邮箱:szkjcyy_wc@126.com 地址:苏州高新区漓江路1号研究方向:
临床麻醉学 重症医学 超声技术在围术期的应用 生命重要脏器保护机制研究 王琛,男,52岁,博士学历 主任医师,教授,博士生导师 南京大学医学院附属苏州医院 党委委员、副院长、麻醉学部主任 江苏省医学重点人才、姑苏卫生重点人才 2005.04~2006.03,美国Medical College of Wisconsin,麻醉系,博士后 2009.02~2009.03,《中华麻醉学杂志》编辑部,客座编辑 2011.11~2011.12,美国University of California Davis Health System,麻醉科,访问学者 临床研究:超声可视化技术在围术期的应用,系本人2006年从美国进修回国后,在江苏省内率先引进的新技术。相关技术先后多次主办国家、省、市级继教班,并多次在各级学术会议上授课。先后获6次省厅、市局级新技术引进奖,并有5项相关超声技术的国家专利授权。 基础研究:心、脑、肾等生命重要脏器的缺血再灌注损伤的发病机制、吸入麻醉药预处理的保护机制、2型糖尿病心肌纤维化的发病机制、放射性脑损伤的保护机制。相关研究项目先后主持国家自然科学基金1项、江苏省自然科学基金2项、苏州市社会发展课题4项。相关研究成果先后获8次省级科技进步奖、5次市级科技进步奖。 中国研究型医院学会麻醉专委会,常委 江苏省中西医结合学会麻醉专委会,副主任委员 江苏省研究型医院学会麻醉与围术期医学专委会,副主任委员 苏州市医学会麻醉学分会,副主任委员 苏州市中西医结合学会麻醉专委会,主任委员 《中华麻醉学杂志》,通讯编委 《中华卫生应急电子杂志》,编委 《实用临床医药杂志》,特约审稿专家 1. Chen Wang#, Donald A Neff, John G Krolikowski, Dorothee Weihrauch, Martin Bienengraeber, David C Warltier, Judy R Kersten, Paul S Pagel*. The influence of B-cell lymphoma 2protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits. Anesthesia & Analgesia, 2006, 102(5): 1355-1360. 2. Chen Wang#, Pascal C Chiari, Dorothee Weihrauch, John G Krolikowski, David C Warltier, Judy R Kersten, Phillip F Pratt Jr, Paul S Pagel*. Gender-specificity of delayed preconditioning by isoflurane in rabbits: potential role of endothelial nitric oxide synthase. Anesthesia & Analgesia, 2006, 103(2): 274-280. 3. Chen Wang#, Dorothee Weihrauch, David A Schwabe, Martin Bienengraeber, David C Warltier, Judy R Kersten, Phillip F Pratt Jr, Paul S Pagel*. Extracellular signal-regulated kinases trigger isoflurane preconditioning concomitant with upregulation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression in rats. Anesthesia & Analgesia, 2006, 103(2): 281-288. 4. Chen Wang#, Hong Xie, Xia Liu, Qin Qin, Xuemei Wu, Hong Liu, Chunfeng Liu*. Role of nuclear factor-ҡB in volatile anaesthetic preconditioning with sevoflurane during myocardial ischaemia/reperfusion. European Journal of Anaesthesiology, 2010, 27(8): 747-756. 5. Hong Xie#, Chen Wang*, Xuemei Wu, Xia Liu, Shigang Qiao, Chunfeng Liu, Hong Liu*. Parthenolide attenuates LPS-induced activation of NF-ҡB in a time-dependent manner in rat myocardium. Journal of Biomedical Research, 2012, 26(1): 37-43. 6. Chen Wang#, Aijie Pei#, Jing Chen, Hailong Yu, Meiling Sun, Chunfeng Liu, Xingshun Xu*. A natural coumarin derivative esculetin offers neuroprotection on cerebral ischemia/reperfusion injury in mice. Journal of Neurochemistry, 2012, 121(6): 1007-1013. 7. Shigang Qiao#, Hong Xie#, Chen Wang*, Xuemei Wu, Hong Liu, Chunfeng Liu. Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-ҡB and upregulation of autophagy. Journal of Anesthesia, 2013, 27(2): 251-260. 8. Hong Xie#, Xia Liu, Chen Wang*, Jiang Zhu, Chen Yang, Chunfeng Liu, Hong Liu*, Xuemei Wu. The changes of technetium-99m-labed annexin-V in delayed anesthetic preconditioning during myocardial ischemia/reperfusion. Molecular Biology Reports, 2014, 41(1): 131-137. 9. Hong Xie#, Jing Zhang#, Jiang Zhu, Lixin Liu, Mario Rebecchi, Sumei Hu, Chen Wang*. Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1/2 pathway. Acta Pharmacologica Sinica, 2014, 35(12): 1504-1513. 10. Hong Xie#, Qin Liu#, Shigang Qiao, Xiuli Jiang, Chen Wang*. Delayed cardioprotection by sevoflurane preconditioning: a novel mechanism via inhibiting Beclin 1-mediated autophagic cell death in cardiac myocytes exposed to hypoxia/reoxygenation injury. International Journal of Clinical and Experimental Pathology, 2015, 8(1): 217-226. 11. Hong Xie#, Qingrong Xu, Jia Jia, Guizhen Ao, Ying Sun, Lifang Hu, Nabil J Alkayed, Chen Wang*, Jian Cheng*. Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux. Biochemical and Biophysical Research Communications, 2015, 458(3): 632-638. 12. Hong Xie#, Gaoming She#, Chen Wang*, Liyuan Zhang, Chunfeng Liu. The gender difference in effect of sevoflurane exposure on cognitive function and hippocampus neuronal apoptosis in rats. European Review for Medical and Pharmacological Science, 2015, 19(4): 647-657. 13. Chen Wang#, Sumei Hu#, Hong Xie*, Shigang Qiao, Hong Liu, Chunfeng Liu. Role of mitochondrial ATP-sensitive potassium channel-mediated PKC-ɛ in delayed protection against myocardial ischemia/reperfusion injury in isolated hearts of sevoflurane-preconditioned rats. Brazilian Journal of Medical and Biological Research, 2015, 48(6): 528-536. 14. Jianfang Cao#, Hong Xie#, Ying Sun, Jiang Zhu, Ming Ying, Shigang Qiao, Qin Shao, Haorong Wu*,Chen Wang*. Sevoflurane post-conditioning reduces rat myocardial ischemia reperfusion injury through an increase in NOS and a decrease in phosphorylated NHE1 levels. International Journal of Molecular Medicine, 2015, 36(6): 1529-1537. 15. Qin Qin#, Debao Yang, Hong Xie, Liyuan Zhang, Chen Wang*. Ultrasound guidance improves the success rate of axillary plexus block: a meta-analysis. Revista Brasileira de Anestesiologia, 2016, 66(2): 115-119. 16. Feiya Hu#, Anmin Shao, Shigang Qiao, Ying Sun, Liuhui Chang, Chen Wang*. Correlation study on postoperative changes in renal hemodynamics and renal function of patients with traumatic brain surgery by color Doppler flow imaging (CDFI). International Journal of Clinical and Experimental Medicine, 2016, 9(2): 1027-1038. 17. Shigang Qiao#, Guofang Mao, Hua Li, Zhimin Ma, Lei Hong, Huiling Zhang, Chen Wang*, Jianzhong An*. DPP-4 inhibitor sitagliptin improves cardiac function and glucose homeostasis and ameliorates ß-cell dysfunction together with reducing S6K1 activation and IRS-1 and IRS-2 degradation in obesity female mice. Journal of Diabetes Research, 2018, 2018: 3641516. 18. Shigang Qiao#, Ying Sun, Bo Sun, An Wang, Jia Qiu, Lei Hong, Jianzhong An, Chen Wang*, Huiling Zhang*. Sevoflurane postconditioning protects against myocardial ischemia/reperfusion injury by restoring autophagic flux via an NO-dependent mechanism. Acta Pharmacologica Sinica, 2019, 40(1): 35-45. 19. Jie Du#, Yanjun Deng#, Hua Li, Shigang Qiao, Mengnan Yu, Qingya Xu,Chen Wang*. Ratio of optic nerve sheath diameter to eyeball transverse diameter by ultrasound can predict intracranial hypertension in traumatic brain injury patients: a prospective study. Neurocritical Care, 2020, 32(2): 478-485. 20. Yanjun Deng#, Ye Fang#, Hua Li, Jiemei Chen, Jianzhong An, Shigang Qiao, Chen Wang*. A preoperative whey protein and glucose drink before hip fracture surgery in the aged improves symptomatic and metabolic recovery. Asia Pacific Journal of Clinical Nutrition, 2020, 29(2): 234-238. 21. Chen Wang#, Shigang Qiao, Lei Hong, Jie Sun, Tuanjie Che, Jianzhong An*, Amadou K S Camara*. NOS cofactor tetrahydrobiopterin contributes to anesthetic preconditioning induced myocardial protection in the isolated ex vivo rat heart. International Journal of Molecular Medicine, 2020, 45(2): 615-622. 22. Shan Zhong#, Hongli Guo, Hui Wang, Dan Xing, Tingting Lu, Jing Yang, Chen Wang*. Apelin-13 alleviated cardiac fibrosis via inhibiting the PI3K/Akt pathway to attenuate oxidative stress in rats with myocardial infarction-induced heart failure. Bioscience Reports, 2020, 40(4): 1-13. 23. Lei Hong#, Ying Sun#, Jianzhong An, Chen Wang*, Shigang Qiao*. Sevoflurane preconditioning confers delayed cardioprotection by upregulating AMP-activated protein kinase levels to restore autophagic flux in ischemia-reperfusion rat hearts. Medical Science Monitor, 2020, 26: e922176-1-e922176-12. 24. Shigang Qiao#, Wenjie Zhao, Huanqiu Li, Guizhen Ao, Jianzhong An, Chen Wang*, Huiling Zhang*. Necrostatin-1 analog DIMO exerts cardioprotective effect against ischemia reperfusion injury by suppressing necroptosis via autophagic pathway in rats. Pharmacology, 2021, 106(3-4): 189-201. 25. Mengnan Yu#, Yanjun Deng#, Jun Cha, Lingyan Jiang, Mingdeng Wang, Shigang Qiao, Chen Wang*. PEEP titration by EIT strategies for patients with ARDS: A Systematic Review and Meta-Analysis. Medicina Intensiva(English Edition), 2023, 47(7): 383-390. 26. Chengyong Gu#,Mo Chen#,Xueyan Li,Dechun Geng,Chen Wang*. MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain. Molecular medicine reports, 2023, 27(6):117. 27. Jun Zha#, Youjia Yu#, Guiru Li, Suchun Wang, Shigang Qiao, Chen Wang*, Huilong Bo*. Lung protection effect of EIT-based individualized protective ventilation strategy in patients with partial pulmonary resection. European Review for Medical and Pharmacological Sciences, 2023, 27: 5459-5467. 1. 国家自然科学基金面上项目,30872453,自噬/溶酶体途径在七氟烷延迟性心肌保护机制中的研究,2009/01-2011/12,25万元,已结题,主持 2. 国家自然科学基金面上项目,81372024,ROS在调控心肌衰老过程中Beclin 1-Vps34复合体功能和自噬流的机制研究,2014/01-2017/12,70万元,已结题,参加(排名第3) 3. 国家自然科学基金面上项目,81473211,RIP1K调节缺血性脑中风星形胶质细胞Necroptosis中溶酶体膜不稳定性的分子机制,2015/01-2018/12,55万元,已结题,参加(排名第2) 4. 国家自然科学基金面上项目,82170468,盐皮质激素受体激活调节mTOR/SGK1/ENaC信号通路参与2型糖尿病介导动脉硬化的机制研究,2022/01-2025/12,53万元,在研,参加(排名第2) 5. 江苏省自然科学基金面上项目,BK2008166,七氟烷延迟性心肌保护作用机制研究:NF-κB介导的自噬/溶酶体途径,2009/01-2010/12,7万元,已结题,主持 6. 江苏省自然科学基金面上项目,BK20141187,自噬溶酶体途径在2型糖尿病心脏功能障碍中的作用,2014/07-2017/06,10万元,已结题,主持 7. 江苏省科教兴卫工程,江苏省医学重点人才-No.145,七氟烷后处理对心肌缺血再灌注损伤的保护机制:抑制胀亡/凋亡信号通路,2011/01-2016/12,50万元,已结题,主持
科技进步奖 [1] 王琛(2/5),预处理对放射性脑损伤防护作用的实验研究,中华人民共和国国防科学技术工业委员会,国防科学技术进步奖,三等奖,2007,2007GFJBJ-3013-2 [2] 王琛(1/5),NF-κB信号通路在七氟烷预处理对大鼠心肌保护机制中的作用,苏州市人民政府,苏州市科学技术进步奖,三等奖,2013,3-16-1 [3] 王琛(1/5),七氟醚对大鼠心肌缺血/再灌注损伤不同保护策略的机制:KATP通道介导的自噬和胀亡,苏州市人民政府,苏州市科学技术进步奖,三等奖,2016,3-25-1 [4] 王琛(2/5),缺血性脑中风神经细胞自噬性死亡及凋亡的信号机制、相互作用及药物干预,苏州市人民政府,苏州市科学技术进步奖,一等奖,2017,1-9-2 [5] 王琛(1/5),改善自噬流修复七氟烷对Ⅱ型糖尿病大鼠心肌缺血再灌注保护,苏州市医学会,医学科学技术奖,三等奖,2019,20181324G1 [6] 王琛(5/5),放射性脑损伤诊疗创新技术研究,江苏省医学会,江苏医学科技奖,二等奖,2019,2019-A-320168P5-5 [7] 王琛(4/5),电离辐射所致海马依赖性认知功能障碍的机制研究,江苏省人民政府,江苏省科学技术奖,三等奖,2019,2018-3-140-R4 [8] 王琛(4/5),认知功能辐射损伤机制和防治关键技术研究,中国核工业集团有限公司,中核集团科学技术奖,二等奖,2020,2019-2-33-04 [9] 王琛(1/9),基于自噬、坏死性凋亡、焦亡途径参与心脑缺血性损伤的药物治疗,中国研究型医院学会,中国研究型医院医学研究创新奖,二等奖,2020,2020-C-2-4-04-R01 [10] 王琛(4/5),认知功能辐射损伤机制和防治的创新技术研究,中华人民共和国工业和信息化部,国防科学技术进步奖,三等奖,2021,2020GFJBJ3006-R04 [11] 王琛(3/7),自噬/溶酶体通路在心脑缺血性损伤中的同质化作用及其药物干预,江苏省人民政府,江苏省科学技术奖,二等奖,2021,2021-2-16-R3 [12] 王琛(1/7),学科积分制考核提升医院核心竞争力的理论与实践研究,苏州市医学会,苏州市医学会医学科技奖,卫生与健康管理奖,2022 新技术引进奖 [1] 王琛(2/3),超声引导下锁骨上和肌间沟臂丛神经阻滞,苏州市卫生局,医学新技术引进奖,三等奖,排名2,2009,苏卫科人[2010]9号文 [2] 王琛(2/3),超声引导穿刺技术在全膝和全髋关节置换术后镇痛中的应用,苏州市卫生局,医学新技术引进奖,二等奖,2011,苏卫科教[2012]5号文 [3] 王琛(2/3),超声技术在全膝、全髋关节置换术患者术后镇痛中的应用,江苏省卫生厅,医学新技术引进奖,二等奖,2012,第121号 [4] 王琛(1/3),超声测定肾功能和胃排空功能技术在围术期重症患者中的临床应用,苏州市卫生和计健康委员会,医学新技术引进奖,二等奖,2016,苏卫计科教[2016]22号文 [5] 王琛(1/3),视神经超声用于预测颅脑损伤患者围术期颅内压升高的临床应用,江苏省卫生健康委员会,医学新技术引进奖,二等奖,2019,2019-2-126-1 [6] 王琛(1/3),视神经超声技术在颅脑损伤患者围术期脑灌注监测中的应用,苏州市卫生健康委员会,苏州市医学新技术引进奖,一等奖,2021,苏卫健科教[2021]37号文 |