作者：2017-07-03浏览次数：13926

杭春华

博士研究生导师简介

姓名

杭春华

研究方向：

脑血管病基础与临床

颅脑创伤

神经干细胞

联系方式

电话：13912968338，Email:hang1965@163.com

学术兼职：

中国医师协会神经外科专业委员会委员

中国医师协会神经外科分会脑血管病学组委员

中华医学会神经外科分会脑血管病学组委员

江苏省第八届神经外科专业委员会副主任委员

江苏省神经外科质量控制专业委员会副主任委员

南京医学会神经外科分会主任委员

江苏省卒中学会神经外科专业委员会副主任委员

中国卒中学会脑血管外科分会委员

中国医药教育协会神经外科专业委员会常委

中国医师协会胶质瘤专业委员会委员

个人简介

1. 工作简介

南京大学医学院附属鼓楼医院神经外科行政主任，医学博士，主任医师，教授，博士生导师，博士后指导教师，南京大学神经外科研究所所长。系江苏省科教兴卫人才工程、江苏省“333”人才工程(第二层次)、军队高层次创新人才工程领军人才培养对象，2011年获得中国神经外科医师最高荣誉-王忠诚中国神经外科医师学术成就奖。2005、2008及2013年分别在美国Barrow神经外科研究所、法国Clertmont-Ferrand大学、澳大利亚墨尔本大学皇家医院进修学习。目前担任南京大学、南京医科大学、徐州医科大学、江苏大学等院校博士生导师，博士后指导老师。

2. 科研情况简介

承担国家科技项目、国家自然科学基金和江苏省自然科学基金等课题10余项，发表学术论文200余篇，其中SCI论文100余篇，获省部级科技进步一等奖1项、二等奖4项、三等奖3项。

3. 主要研究方向简介

（1）创伤性脑损伤：颅脑创伤是常见外伤类型之一，具有高致残率及致死率等特点。科室于2017年成立神经创伤与重症中心，专职于颅脑创伤的救治。前期发表相关SCI论文30余篇，获教育部自然科学二等奖1项，江苏省科技进步二等奖1项。目前，科室已注册两项颅脑创伤相关的临床前瞻性研究，旨在通过蛋白组学筛选出能准确预测患者预后的因子，开展以脑灌注为核心的多模态监测，指导临床治疗与护理工作。在基础研究上，紧跟国际热点与新点，开展脑创伤后神经再生机制与功能调控研究，扭转当前“无药可医”的困境。

（2）颅内动脉瘤的基础和临床研究：随着社会老龄化的到来，脑血管病已成为危害我国中老年人健康乃至生命的主要疾病。卫生部疾控中心资料表明脑血管病在近年全部死亡病因顺位中呈现明显前移的趋势，甚至超过肿瘤排位第一要因。我科于2017年组建脑血管病外科治疗中心，搭建复合手术室，成立脑血管病诊治中心，聚焦于复杂脑血管疾病的外科治疗。截至2019年，脑血管病中心展开床位70张，脑血管病年手术量超1200台，居国内前列，省内第一，相关技术水平达到国内领先地位。累计发表相关SCI论著 50余篇，申请专利 1项，获教育部科技进步一等奖1项，江苏省科技进步三等奖1项。目前，中心已构建脑血管病信息平台，开展动脉瘤蛋白组学及分子影像诊断、临床预后分析、动静脉畸形多模态影像技术融合、解剖学边界与血流灌注边界、烟雾病静息态脑网络与认知相关性等研究。同时，积极完成出血性脑血管病病理生理分子机制探索，稳步推动临床与基础齐头并进，有效促进基础成果向临床转化。

（3）神经干细胞研究：神经元损伤与死亡是中枢神经系统损伤后遗症产生的关键因素，促进已损伤或死亡神经元的修复与再生是神经科学领域基础研究的重中之重。科室目前已引进博士后等相关人才，进行神经干细胞的基础研究，科研方向主要集中在外科相关疾病，即垂体干细胞对垂体功能低下的治疗作用、神经干细胞对创伤性脑损伤的神经再生作用、神经干细胞对退行性脑疾病(如帕金森)的神经调控等三大方面。结合鼓楼医院干细胞研究中心、神经内科、内分泌科、基础医学与生命科学院、南京大学模式动物研究所等机构的优势条件，探索出神经干细胞应用于临床的有效方法并加以推广。


代表性论文[近5年通讯作者和第一作者]

  1. Zhang D, Yan H, Hu Y, Zhuang Z, Yu Z, Hang C. Increased Expression of NLRP3 Inflammasome in Wall of Ruptured and Unruptured Human Cerebral Aneurysms: Preliminary Results. J Stroke Cerebrovasc Dis. 2015 May;24(5):972-9.

  2. Yu Z, Li H, Yan HY, Yang YQ, Zhang DD, Huang LT, Xie GB, Liu M, Tohti M, Hang CH. Expression and Cell Distribution of SENP3 in Brain Tissue After Traumatic Brain Injury in Mice: A Pilot Study. Cell Mol Neurobiol. 2015 Jul;35(5):733-40.

  3. Yan H, Hao S, Sun X, Zhang D, Gao X, Yu Z, Li K, Hang CH. Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage. Biochem Biophys Res Commun. 2015 Jan 24;456(4):835-40.

  4. Yang YQ, Li H, Zhang X, Wang CX, Sun Q, Li S, Li W, Li W, Ding K, Liu M, Yu Z, Hang CH. Expression and Cell Distribution of SENP3 in the Cerebral Cortex After Experimental Subarachnoid Hemorrhage in Rats: A Pilot Study. Cell Mol Neurobiol. 2015 Apr;35(3):407-16.

  5. Huang LT, Li H, Sun Q, Liu M, Li WD, Li S, Yu Z, Wei WT, Hang CH. IL-33 Expression in the Cerebral Cortex Following Experimental Subarachnoid Hemorrhage in Rats. Cell Mol Neurobiol. 2015 May;35(4):493-501.

  6. Zhang D, Yan H, Li H, Hao S, Zhuang Z, Liu M, Sun Q, Yang Y, Zhou M, Li K, Hang C. TGFβ-activated kinase 1 (TAK1) inhibition by 5Z-7-oxozeaenol attenuates early brain injury after experimental subarachnoid hemorrhage. J Biol Chem. 2015 Aug 7;290(32):19900-9.

  7. Yan H, Zhang D, Hao S, Li K, Hang CH. Role of Mitochondrial Calcium Uniporter in Early Brain Injury After Experimental Subarachnoid Hemorrhage. Mol Neurobiol. 2015，52(3):1637-47.

  8. Yang YQ, Li H, Zhang XS, Li W, Huang L, Yu Z, Jiang T, Chen Q, Hang CH. Inhibition of SENP3 by lentivirus induces suppression of apoptosis in experimental subarachnoid hemorrhage in rats. Brain Res. 2015 Oct 5;1622:270-8.

  9. Zhang XS, Zhang X, Zhang QR, Wu Q, Li W, Jiang TW, Hang CH. Astaxanthin reduces matrix metalloproteinase-9 expression and activity in the brain after experimental subarachnoid hemorrhage in rats.Brain Res. 2015 Oct 22;1624:113-24.

  10. Zhang XS, Li W, Wu Q, Wu LY, Ye ZN, Liu JP, Zhuang Z, Zhou ML, Zhang X, Hang CH. Resveratrol Attenuates Acute Inflammatory Injury in Experimental Subarachnoid Hemorrhage in Rats via Inhibition of TLR4 Pathway. Int J Mol Sci. 2016 Aug 12;17(8).

  11. Zhang ZH, Han YL, Wang CX, Zhou CH, Wu LY, Zhang HS, Chen Q, Fan JM, Zhou ML, Hang CH. The effect of subarachnoid erythrocyte lysate on brain injury: a preliminary study. Biosci Rep. 2016 Jul 15;36(4).

  12. Zhang HS, Li H, Zhang DD, Yan HY, Zhang ZH, Zhou CH, Ye ZN, Chen Q, Jiang TW, Liu JP, Hang CH. Inhibition of myeloid differentiation factor 88(MyD88) by ST2825 provides neuroprotection after experimental traumatic brain injury in mice. Brain Res. 2016 Jul 15;1643:130-9.

  13. Li H, Yu JS, Zhang DD, Yang YQ, Huang LT, Yu Z, Chen RD, Yang HK, Hang CH. Inhibition of the Receptor for Advanced Glycation End-Products (RAGE) Attenuates Neuroinflammation While Sensitizing Cortical Neurons Towards Death in Experimental Subarachnoid Hemorrhage. Mol Neurobiol. 2017 Jan;54(1):755-767.

  14. Zhang D, Zhang H, Hao S, Yan H, Zhang Z, Hu Y, Zhuang Z, Li W, Zhou M, Li K, Hang C. Akt Specific Activator SC79 Protects against Early Brain Injury following Subarachnoid Hemorrhage. ACS Chem Neurosci. 2016 Jun 15;7(6):710-8.

  15. Zhang D, Wu W, Yan H, Jiang T, Liu M, Yu Z, Li H, Hang C. Upregulation of HMGB1 in wall of ruptured and unruptured human cerebral aneurysms: preliminary results. Neurol Sci. 2016 Feb;37(2):219-26.

  16. Hou WZ, Chen XL, Wu W, Hang CH.MicroRNA-370-3p inhibits human vascular smooth muscle cell proliferation via targeting KDR/AKT signaling pathway in cerebral aneurysm. Eur Rev Med Pharmacol Sci. 2017 Mar;21(5):1080-1087.

  17. Li S, Xiao X, Ni X, Ye Z, Zhao J, Hang CTetramethylpyrazine Protects against Early Brain Injury after Experimental Subarachnoid Hemorrhage by Affecting Mitochondrial-Dependent Caspase-3 Apoptotic Pathway. Evid Based Complement Alternat Med. 2017;2017:3514914.

  18. Ye ZN, Liu JP, Wu LY, Zhang XS, Zhuang Z, Chen Q, Lu Y, Liu CG, Zhang ZH, Zhang HS, Hou WZ, Hang CH. Downregulation of miR-204 expression correlates with poor clinical outcome of glioma patients. Hum Pathol. 2017 Feb 20. pii: S0046-8177(17)30047-3.

  19. Xia DY, Zhang HS, Wu LY, Zhang XS, Zhou ML, Hang CH. Pentoxifylline Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats: Possibly via Inhibiting TLR 4/NF-κB Signaling Pathway. Neurochem Res. 2017 Apr;42(4):963-974.

  20. Zhang XS, Wu Q, Wu LY, Ye ZN, Jiang TW, Li W, Zhuang Z, Zhou ML, Zhang X, Hang CH. Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats. Cell Death Dis. 2016 Oct 13;7(10):e2416.

  21. Ye ZN, Zhuang Z, Wu LY, Liu JP, Chen Q, Zhang XS, Zhou ML, Zhang ZH, Li W, Wang XL, Hang CH. Expression and cell distribution of leukotriene B4 receptor 1 in the rat brain cortex after experimental subarachnoid hemorrhage. Brain Res. 2016 Dec 1;1652:127-134.

  22. Li H, Yu JS, Zhang HS, Yang YQ, Huang LT, Zhang DD, Hang CH. Increased Expression of Caspase-12 After Experimental Subarachnoid Hemorrhage. Neurochem Res. 2016，41(12):3407-3416.

  23. Chen Q, Ye ZN, Liu JP, Zhang ZH, Zhou CH, Wang Y, Hang CH. Elevated cerebrospinal fluid levels of thrombospondin-1 correlate with adverse clinical outcome in patients with aneurysmal subarachnoid hemorrhage. J Neurol Sci. 2016 Oct 15;369:126-30.

  24. Ye Z, Zhang Z, Wu L, Liu C, Chen Q, Liu J, Wang X, Zhuang Z, Li W, Xu S, Hang C. Upregulation of miR-183 expression and its clinical significance in human brain glioma. Neurol Sci. 2016 Aug;37(8):1341-7.

  25. Zhang X, Wu Q, Zhang Q, Lu Y, Liu J, Li W, Lv S, Zhou M, Zhang X, Hang C.Resveratrol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage via Inhibition of NLRP3 Inflammasome Activation.Front Neurosci. 2017 Nov 3;11:611.

  26. Yan H, Zhang D, Wei Y, Ni H, Liang W, Zhang H, Hao S, Jin W, Li K, Hang CH. Inhibition of myeloid differentiation primary response protein 88 provides neuroprotection in early brain injury following experimental subarachnoid hemorrhage.Sci Rep. 2017 Nov 17;7(1):15797.

  27. Ye ZN, Wu LY, Liu JP, Chen Q, Zhang XS, Lu Y, Zhou ML, Li W, Zhang ZH, Xia DY, Zhuang Z, Hang CH. Inhibition of leukotriene B4 synthesis protects against early brain injury possibly via reducing the neutrophil-generated inflammatory response and oxidative stress after subarachnoid hemorrhage in rats. Behav Brain Res. 2018 Feb 26;339:19-27.

  28. Lu Y, Zhang XS, Zhou XM, Gao YY, Chen CL, Liu JP, Ye ZN, Zhang ZH, Wu LY, Li W, Hang CH. Peroxiredoxin 1/2 protects brain against H2O2-induced apoptosis after subarachnoid hemorrhage. FASEB J. 2018 Oct 23:fj201801150R.

  29. Sun B, Yang S, Li S, Hang C. Melatonin Upregulates Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2) and Mediates Mitophagy to Protect Against Early Brain Injury After Subarachnoid Hemorrhage. Med Sci Monit. 2018 Sep 13;24:6422-6430.

  30.   Gao YY, Zhang ZH, Zhuang Z, Lu Y, Wu LY, Ye ZN, Zhang XS, Chen CL, Li W, Hang CH. Recombinant milk fat globule-EGF factor-8 reduces apoptosis via integrin β3/FAK/PI3K/AKT signaling pathway in rats after traumatic brain injury. Cell Death Dis. 2018 Aug 28;9(9):845.

  31. Yang S, Chen X, Li S, Sun B, Hang C. Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH). ‘’Med Sci Monit. 2018 Jun 6;24:3804-3814.

  32. Liu JP, Ye ZN, Lv SY, Zhuang Z, Zhang XS, Zhang X, Wu W, Mao L, Lu Y, Wu LY, Fan JM, Tian WJ, Hang CH. The rise of soluble platelet-derived growth factor receptor β in CSF early after subarachnoid hemorrhage correlates with cerebral vasospasm. Neurol Sci. 2018 Jun;39(6):1105-1111.

  33. Zhang H, Zhang D, Li H, Yan H, Zhang Z, Zhou C, Chen Q, Ye Z, Hang C. Biphasic activation of nuclear factor-κB and expression of p65 and c-Rel following traumatic neuronal injury. Int J Mol Med. 2018 Jun;41(6):3203-3210.

  34. Lu Y, Zhang XS, Zhang ZH, Zhou XM, Gao YY, Liu GJ, Wang H, Wu LY, Li W, Hang CH. Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage. J Neuroinflammation. 2018 Mar 19;15(1):87.

  35. Jiang T, Wu W, Zhang H, Zhang X, Zhang D, Wang Q, Huang L, Wang Y, Hang C. High expression of B7-H6 in human glioma tissues promotes tumor progression. Oncotarget. 2017 Jun 6;8(23):37435-37447.

  36. Gao Y, Zhuang Z, Lu Y, Tao T, Zhou Y, Liu G, Wang H, Zhang D, Wu L, Dai H, Li W, Hang C. Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage.Front Neurosci. 2019 Nov 15;13:1223.

  37. Zhang D, Yan H, Wei Y, Liu X, Zhuang Z, Dai W, Li J, Li W, Hang C. C-Reactive Protein/Albumin Ratio Correlates With Disease Severity and Predicts Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage.Front Neurol. 2019 Nov 12;10:1186.

  38. Tao T, Liu GJ, Shi X, Zhou Y, Lu Y, Gao YY, Zhang XS, Wang H, Wu LY, Chen CL, Zhuang Z, Li W, Hang CH. DHEA Attenuates Microglial Activation via Induction of JMJD3 in Experimental Subarachnoid Haemorrhage. J Neuroinflammation. 2019 Nov 28;16(1):243.

  39. Tao T, Dai W, Li W, Hang CH. Giant Serpentine Distal Anterior Cerebral Artery Aneurysm Treated with In Situ Side-to-Side A3-A3 Anastomosis and Aneurysm Resection. World Neurosurg. 2019 Sep 14;133:21-24.

  40. Chen T, Zhu J, Wang YH, Hang CH. ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury. Neuroscience. 2019 Sep 15;416:268-280.

  41. Wang H, Zhou XM, Xu WD, Tao T, Liu GJ, Gao YY, Lu Y, Wu LY, Yu Z, Yuan B, Hang CH, Li W. Inhibition of Elevated Hippocampal CD24 Reduces Neurogenesis in Mice With Traumatic Brain Injury. J Surg Res. 2020 Jan;245:321-329.

  42. Zhang D, Zhuang Z, Wei Y, Liu X, Li W, Gao Y, Li J, Hang C. Association of Admission Serum Glucose-Phosphate Ratio with Severity and Prognosis of Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2019 Jul;127:e1145-e1151.

  43. Lu Y, Zhang XS, Zhou XM, Gao YY, Chen CL, Liu JP, Ye ZN, Zhang ZH, Wu LY, Li W, Hang CH. Peroxiredoxin 1/2 protects brain against H2O2-induced apoptosis after subarachnoid hemorrhage. FASEB J. 2019 Feb;33(2):3051-3062.

  44. Zhang X, Lu Y, Wu Q, Dai H, Li W, Lv S, Zhou X, Zhang X, Hang C, Wang J. Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway. FASEB J. 2019 Jan;33(1):722-737.

  45. Wang H, Zhou XM, Xu WD, Hang CH. Inhibition of Elevated Hippocampal CD24 Reduces Neurogenesis in Mice With Traumatic Brain Injury. J Surg Res. 2020; 245:321–329.

  46. Chen T, Zhu J, Wang YH, Hang CH. Arc silence aggravates traumatic neuronal injury via mGluR1-mediated ER stress and necroptosis. Cell Death Dis. 2020;11(1):4. Published 2020 Jan 2. doi:10.1038/s41419-019-2198-5

  47. Liu X, Chen J, Li W, Hang C, Dai Y. Inhibition of Casein Kinase II by CX-4945, But Not Yes-associated protein (YAP) by Verteporfin, Enhances the Antitumor Efficacy of Temozolomide in Glioblastoma. Transl Oncol. 2020;13(1):70–78.

  48. Liu GJ, Zhang QR, Gao X, Hang CH. MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4/IRAK1/TRAF6 Associated Pathways. Front Neurosci. 2020;14:311.

  49. Tao T, Dai W, Li W, Hang CH. Giant Serpentine Distal Anterior Cerebral Artery Aneurysm Treated with In Situ Side-to-Side A3-A3 Anastomosis and Aneurysm Resection. World Neurosurg. 2020;133:21–24.

  50. Dai W, Zhuang Z, Ling H, Yang Y, Hang C. Systematic review and network meta-analysis assess the comparative efficacy and safety of transsphenoidal surgery for pituitary tumor [published online ahead of print, 2020 Feb 8]. Neurosurg Rev. 2020;10.1007/s10143-020-01240-3. doi:10.1007/s10143-020-01240-3


承担科研项目[项目负责人]

  1. 国家自然科学基因面上项目(81371294)高迁移率族蛋白1在蛛网膜下腔出血后脑损伤中作用机制(2014.01-2016.12)

  2. 国家自然科学基金面上项目 (81171170)创伤性脑损伤后不同时期脑内核因子-κB双向作用的实验研究 (2012.01-2015.12)

  3. 国家自然科学基金面上项目（81771291）D24在蛛网膜下腔出血后神经修复中的作用机制研究（2018年01月至2021年12月）

  4. 江苏省自然科学基金面上项目(BK20141375)糖基化终末产物受体在蛛网膜下腔出血后脑损伤中的作用机制研究（2015.01-2017.06）

  5. 国家“十二五”科技支撑计划课题(子课题)脑动脉瘤微创治疗时机及治疗方案优化研究（2011.09-2015.12）

  6. 江苏省自然科学基金面上项目(BK2010459)蛛网膜下腔出血后JAK/STAT信号转导通路对继发性脑损害的作用研究（2011.1-2012-12）

  7. 江苏省自然科学基金面上项目（BK2007153）蛛网膜下腔出血后脑血管Toll样受体信号转导通路研究 （2007.8-2008.12）

  8. 江苏省“333人才工程”科研基金 (BRA2010196)蛛网膜下腔出血后JAK/STAT信号转导通路对继发性脑损害的作用研究（2011.1-2012.12）



获奖情况

  1. 《创伤性脑损伤与肠功能障碍的相关性研究》教育部科技进步二等奖（排名第一），2007年12月

  2. 《创伤性脑损伤后肠功能障碍及其对脑功能影响的基础研究》江苏省科技进步二等奖（排名第一），2008年12月

  3. 《颅内动脉瘤的基础和临床研究》 教育部科技进步一等奖（排名第二），2009年12月

  4. 《创伤性脑损伤后肠功能障碍及其对脑功能影响的基础研究》 中华医学科技进步三等奖（排名第一），2009年10月

  5. 《创伤性脑损伤后损害相关分子模式的信号转导机制及靶向干预研究》教育部自然科学二等奖（排名第一），2018年10月

  6. 《损害相关分子模式在蛛网膜下腔出血后早期脑损伤中作用机制及靶向干预研究》江苏省科技进步三等奖（排名第一），2019年12月



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