杨中州

文章来源:南京大学医学院发布时间:2019-07-26浏览次数:11

基础医学博士研究生导师简介

姓   名

杨中州

联系方式

电子邮件:zhongzhouyang@nju.edu.cn

研究方向

心脏发育与心肌重塑

电话:83592264

实验室网页


学术兼职

  • 中国细胞生物学会常务理事,发育生物学分会会长

  • 国家心血管病专家委员会先心病专业委员会常委

学习和工作简历

1997年于北京大学医学部获得医学硕士学位;1998年作为访问学者在美国宾夕法尼亚大学工作学习;2004年于瑞士巴塞尔大学/弗里德里奇-米歇尔生物医学研究所获得博士学位;2005年进入南京大学工作。

研究方向

利用小鼠模型,研究心血管系统发育和心肌重塑以及心肌再生的调控机制。研究方向包括:

1.心脏流出道发育

2.第二心场祖细胞发育

3.心肌发育,重塑与再生

科学问题

1.流出道发育过程中细胞转分化的调控机制。

2.细胞器互作及代谢调控心肌发育的机理。

代表性论文[通讯作者]

  1. Meng Xia, Wen Luo, Hengwei Jin and Zhongzhou Yang*. (2019) HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis. Development. 146(13). pii: dev177477. (封面)

  2. Hengwei Jin, Huijuan Wang, Jie Li, Shan Yu, Mingjie Xu, Zhiqian Qiu, Meng Xia, Jingai Zhu, Qiuting Feng, Jun Xie, Biao Xu and Zhongzhou Yang*. (2019)Differential contribution of the two waves of cardiac progenitors and their derivatives to aorta and pulmonary artery. Dev. Biol.45082-89.

  3. Qi Xiao, Guoxin Zhang, Huijuan Wang, Lai Chen, Shuangshuang Lu, Dejing Pan, Geng Liu* and Zhongzhou Yang*. (2017) A p53 based genetic tracing system to follow postnatal cardiomyocyte expansion in heart regeneration. Development 144: 580-589.(Feature文章/封面)

  4. Wen Luo, Xia Zhao, Hengwei Jin, Lichan Tao, Jingai Zhu, Huijuan Wang, Brian A. Hemmings and Zhongzhou Yang*. (2015) Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development. Development142, 732-742.

  5. Junwei Nie, Mingyang Jiang, Xiaotian Zhang, Hao Tang, Hengwei Jin, Xinyi Huang, Baiyin Yuan, Chenxi Zhang, Janice Ching Lai, Yoshikuni Nagamine, Dejing Pan, Wengong Wang* and Zhongzhou Yang*. (2015) Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development.Cell Rep.13:723-732. (封面)

  6. Xia Zhao, Shuangshuang Lu, Junwei Nie, Xiaoshan Hu, Wen Luo, Xiangqi Wu, Hailang Liu, Qiuting Feng, Zai Chang, Yaoqiu Liu, Yunshan Cao, Haixiang Sun, Xinli Li, Yali Hu, Zhongzhou Yang*. (2014) Phosphoinositide-dependent Kinase 1 and mTORC2 synergisticallymaintain postnatal heart growth and heart function in mice. Mol. Cell. Biol.34 (11):1966-75. (spotlight文章/封面)

  7. Baiyin Yuan,Ping Wan,Dandan Chu,Junwei Nie,Yunshan Cao,Wen Luo,Shuangshuang Lu,Jiong Chen* and Zhongzhou Yang*. (2014) A Cardiomyocyte-Specific Wdr1 Knockout Demonstrates Essential Functional Roles for Actin Disassembly during Myocardial Growth and Maintenance in Mice.Am J Pathol. 184 (7):1967-80.

  8. Qiuting Feng, Ruomin Di, Fang Tao, Zai Chang, Shuangshuang Lu, Wenjing Fan, Congjia   Shan, Xinli Li* and Zhongzhou Yang*. (2010) PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development. Mol. Cell. Biol.30: 3711-3721. (spotlight文章)

  9. Zai Chang, Qin Zhang, Qiuting Feng, Jie Xu, Teng Teng, Qing Luan, Congjia Shan, Yali Hu, Brian A Hemmings, Xiang Gao and Zhongzhou Yang*. (2010) Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation. Dev. Biol.347: 384-391.


承担科研项目[项目负责人]

  • 主持在研国家自然科学基金重大计划培育项目一项,面上项目一项。

获奖情况

  • 国家科技进步奖二等奖(2016,排名第3)