作者:2018-12-25浏览次数:15272

李冬梅

博士研究生导师简介

姓名

李冬梅

研究方向

  • 环境污染与健康

  • 泌尿生殖系肿瘤发生的机制研究

联系方式

Email: lidm@nju.edu.cn

学术兼职:

中国解剖学会 会员

江苏省解剖学会第十二届理事会组织胚胎学专业委员会 委员

江苏省免疫学会转化医学专业委员会 委员

《中华男科学》杂志 编委

南京口腔医学会 副理事长

环境毒理类SCI杂志审稿专家

个人简介

教育和工作经历:

19976月 获南京医科大学临床医学学士学位

20076月 获南京大学理学博士学位

201311月—201411月,美国国立卫生院肿瘤研究中心 访学学者

20078至今 南京大学医学院讲师、副教授,博士生导师

教学:

首批江苏省一流本科课程、南京大学“百”层次优质课程《组织学和胚胎学》主讲教师,公选课《人类生殖与胚胎发生》主讲教师;

《组织病理学》、《疾病研究的生物学方法》和《生殖生物学》等研究生课程主讲教师

代表性论文[5年通讯作者和第一作者]

  1.  Ma T, Zhou Y, Xia Y, Jin H, Wang B, Wu J, Ding J, Wang J, Yang F, Han X, Li D*. Environmentally relevant perinatal exposure to DBP disturbs testicular development and puberty onset in male mice. Toxicology. 2021 Jul 16; 459:152860.

  2.  Yang L, Chen Y, Liu N, Shi Q, Han X, Gan W*, Li D*. Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN. J Hematol Oncol. 2021 Mar 19;14(1):46.

  3.  Wang B, Gan W*, Han X, Liu N, Ma T, Li D*. The positive regulation loop between NRF1 and NONO-TFE3 fusion promotes phase separation and aggregation of NONO-TFE3 in NONO-TFE3 tRCC. Int J Biol Macromol. 2021 Feb 13; 176:437-447.

  4.  Bo Wang, Xiaoqin Yin, Weidong Gan*, Fan Pan, Shiyuan Li, Zou Xiang, Xiaodong Han, Dongmei Li*. PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma. Autophagy. 2020 Oct 21;1-19. doi: 10.1080/15548627.2020.1831815. Online ahead of print.

  5.  Yiqi Zhu, Ning Liu, Wei Guo, Xiaohong Pu, Hongqian Guo, Weidong Gan*, Dongmei Li*. ALK rearrangement in TFE3-positive renal cell carcinoma: Alternative diagnostic option to exclude Xp11.2 translocation carcinoma. Pathol Res Pract. 2020 Dec;216(12):153286. doi: 10.1016/j.prp.2020.153286. Epub 2020 Nov 9.

  6.  Liu N, Guo W, Shi Q, Zhuang W, Pu X, Chen S, Qu F, Xu L, Zhao X, Li X, Zhang G, Guo H, Gan W*, Li D*. The suitability of NONO-TFE3 dual-fusion FISH assay as a diagnostic tool for NONO-TFE3 renal cell carcinoma. Sci Rep. 2020 Oct 1;10(1):16361. doi: 10.1038/s41598-020-73309-4. PMID: 33004995; PMCID: PMC7530984.

  7.  Tan Ma, Yuan Zhou, Yunhui Xia, Xiannan Meng, Haibo Jin, Bo Wang, Yusheng Chen, Jiayin Qiu, Jiang Wu, Jie Ding, Xiaodong Han, Dongmei Li*. Maternal Exposure to Di- n-butyl Phthalate Promotes the Formation of Testicular Tight Junctions through Downregulation of NF-κB/COX-2/PGE 2/MMP-2 in Mouse Offspring. Environ Sci Technol. 2020 Jul 7;54(13):8245-8258.

  8.  Tan Ma, Jiwei Hou, Yuan Zhou, Yusheng Chen, Jiayin Qiu, Jiang Wu, Jie Ding, Xiaodong Han, Dongmei Li*. Dibutyl phthalate promotes juvenile Sertoli cell proliferation by decreasing the levels of the E3 ubiquitin ligase Pellino 2. Environ Health. 2020 Aug 1;19(1):87.

  9.  Xiannan Meng, Ling Zhang, Jiwei Hou, Tan Ma, Chun Pan, Yuan Zhou, Ruitong Han, Yuanzhen Ding, Haoran Peng, Zou Xiang, Dongmei Li*, Xiaodong Han*. The Mechanisms in the Altered Ontogenetic Development and Lung-Related Pathology in Microcystin-Leucine Arginine (MC-LR)-paternal-exposed Offspring Mice. Sci Total Environ. 2020 Sep 20; 736:139678.

  10. Yunhui Xia, Tan Ma, Jie Ji, Liupan Zhang, Yu Wang, Jiang Wu, Jie Ding, Xiaodong Han*, Dongmei Li*. In utero exposure to DBP stimulates release of GnRH by increasing the secretion of PGE2 in the astrocytes of the hypothalamus in the offspring mice. Ecotoxicol Environ Saf. 2020 May 7; 198:110698.

  11.  Ling Zhang, Xiannan Meng, Chun Pan, Feng Qu, Weidong Gan, Zou Xiang, Xiaodong Han*, Dongmei Li*. piR-31470 epigenetically suppresses the expression of glutathione S-transferase pi 1 in prostate cancer via DNA methylation. Cell Signal. 2020 Mar; 67:109501.

  12.  Yuan Zhou, Tan Ma, Minghao Yan, Xiannan Meng, Jiang Wu, Jie Ding, Xiaodong Han*, Dongmei Li*. Exposure of DBP in gestation induces inflammation of testicular Sertoli cells in progeny by activating NLRP3 inflammasomes.Sci Total Environ. 2020 Mar 10;707:136139.

  13.  Yabing Chen, Jing Wang, Dihui Xu, Zou Xiang, Jie Ding, Xiaoyu Yang, Dongmei Li*, Xiaodong Han*. M6A mRNA Methylation Regulates Testosterone Synthesis Through Modulating Autophagy in Leydig Cells. Autophagy. 2020 Jan 31;1-19.

  14.  Ruitong Han, Ling Zhang, Weidong Gan, Kai Fu, Ke Jiang, Jie Ding, Jiang Wu, Xiaodong Han*, Dongmei Li*.piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine. Prostate. 2019 Mar 22. 79: 798-812.

  15.  Yin X, Wang B, Gan W, Zhuang W, Xiang Z, Han X*, Li D*. TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas. J Exp Clin Canc Res, 2019, Mar 8, 38(1): 119.

  16.  Ning Liu, Weidong Gan, Feng Qu, Zhen Wang, Wenyuan Zhuang, Sezim Agizamhan, Linfeng Xu, Juanjuan Yin,Hongqian Guo, and Dongmei Li*. Does the Fuhrman or World Health Organization/International Society of Urological Pathology Grading System Apply to the Xp11.2 Translocation Renal Cell Carcinoma?A 10-Year Single-Center Study. Am J Pathol. 2018 Apr;188(4):929-936.

  17.  Ling Zhang, Xiannan Meng, Zou Xiang, Dongmei Li*, Xiaodong Han*. Roles of mmu_piR_003399 in microcystin-leucine arginine (MC-LR)-induced reproductive toxicity in the spermatogonial cells and testis. Toxicological Sciences, 2018 Jan 1;161(1), 2018, 159–170.

  18.  Xiaoqin Yin, Tan Ma, Ruitong Han, Jie Ding, Huan Zhang(*), Han Xiaodong(*), Li DongMei*, MiR-301b-3p/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)–induced proliferation by targeting Rasd1 in Sertoli cells. Toxicol In Vitro. 2018 Mar;47:79-88.

  19.  Chen Yabing, Wang Jing, Pan Chun, Li Dongmei*, Han Xiaodong*. Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and molecular life sciences, Cell. Mol. Life Sci. 2018 Mar; 75:1117–1132.

  20.  Tan Ma, Xiaoqin Yin, Ruitong Han, Jie Ding, Huan Zhang, Xiaodong Han and Dongmei Li*. Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat. International Journal of Environmental Research and Public Health. 2017, Oct 24;14, 1284.

  21.  Lei Xiong, Xiancheng Chen, Ning Liu, Zhen Wang, Baolei Miao, Weidong Gan*, Dongmei Li*, Hongqian Guo. PRCC-TFE3 dual-fusion FISH assay: A new method for identifying PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue. PLoS ONE2017 Sep 26; 12(9): e0185337.

  22.  Zhang Ling, Zhang Hui, Zhang Huan, Benson Mikael, Han Xiaodong, Li Dongmei*. Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring. Food Chem Toxicol. 2017 Apr 13; 105:177-185.

  23. Hui Zhang, LihuiWang, SongShen, Chenchen Wang, Zou Xiang, Xiaodong Han*, Dongmei Li*. Toxic effects of microcystin-LR on the development of prostate in mice.Toxicology. 2017 Apr 1; 380:50-61.

承担科研项目[项目负责人]

  1. 增塑剂邻苯二甲酸二丁酯胚胎期暴露引起雄性小鼠青春期提前的分子机制研究 国家自然科学基金(31971517

  2. miR-7a表达上调在邻苯二甲酸二丁酯(DBP)干扰青春期前睾丸支持细胞增殖中的机制研究 国家自然科学基金(21377052

  3. 水体典型环境内分泌干扰物联合作用雄性生殖功能影响的机制研究国家自然科学基金(30800115

  4. miR-7的表达下调在前列腺癌发生中的机制研究江苏省自然科学基金(BK20131281

  5. 雌激素受体β亚型(ER-β)基因多态性与前列腺癌易感的相关性研究江苏省自然科学基金(BK2010367

  6. ER-β基因启动子区甲基化水平与前列腺癌易感的相关性研究江苏省第八批“六大人才高峰”高层次人才培养对象项目(卫生行业2011-WS070

  7. 水体典型环境内分泌干扰物联合作用雄性生殖功能影响的机制研究 教育部新青年教师基金(200802841006

  8. Xp11.2易位型肾癌分子诊断模型的建立 生命分析化学国家重点实验室自主研究课题(5431ZZXM2004

  9. miR-7的表达下调在前列腺癌发生中的机制研究 生命分析化学国家重点实验室开放研究基金

获奖情况

  • 2020年 南京大学“魅力导师奖”

  • 2019年 江苏省高校微课教学比赛 三等奖

  • 2018年 江苏省教育教学与研究成果奖(研究类)三等奖

  • 2018年 南京大学“魅力导师奖”

  • 2017年 华东地区青年学者高峰论坛青年学者奖

  • 2017年 南京大学教学成果奖

  • 2016年 南京大学创新育人奖

  • 2015年 南京大学医学院优秀教师