王 勇

文章来源:南京大学医学院发布时间:2018-12-24浏览次数:6672

博士研究生导师简介

姓名

王勇

研究方向

疾病分析,生殖:多囊卵巢综合征及其运动干预,溃疡性结肠炎,

联系方式

南京大学医学院科技馆215

电话:83594755Emailyongwang@nju.edu.cn

学术兼职:

中国免疫学会终身会员;中国解剖学会会员;江苏省解剖学会理事兼副秘书长;江苏省细胞学会生殖分会理事;江苏省动物学会会员;

个人简介

王勇,南京大学博士,南京大学基础医学教授,江苏省动商产业研究院院长;江苏省医学分子技术重点实验室PI兼秘书,生命分析化学国家重点实验室PI;教学课程:《正常人体结构学》、《组织学与胚胎学》、《组织学与胚胎学实验》、《组织病理学》、《实验免疫学》、《实验动物学》、《组织病理》、《生殖生物学》、《人类生殖》等;科研方向为疾病分析,生殖:多囊卵巢综合征(PCOS)及其运动干预,溃疡性结肠炎等;主持多囊卵巢综合征相关国家自然科学基金6项,主持横向课题8项,参与973、国家科技重大专项、国自然等7项;发表文章100余篇,其中SCI论文50余篇。

代表性论文[5年通讯作者和第一作者]

  1. Daojuan Wang,Yajing Weng,Yaling Zhang,Rong Wang,Tingyu Wang,Jianjun Zhou,Shanmei Shen,Hongwei Wang,Yong Wang. Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice. Sci Total Environ2020 Jul 22;745:141049.

  2. Daojuan Wang,Tingyu Wang,Rong Wang,Xinlin Zhang,Lei Wang,Zou Xiang,Lingjia Zhuang,Shanmei Shen,Hongwei Wang,Qian Gao,Yong Wang. Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis. J Transl Med2020 Feb 17;18(1):84.

  3. Qin Liu, Maomao Zhao, Wei Chen, Kaiyuan Xu, Fan Huang, Junxing Qu, Zhen Xu, Xiang Wang, Yong Wang, Yanan Zhua, Wenmei Wang, Mainstream cigarette smoke induces autophagy and promotes apoptosis in oral mucosal epithelial cells. Archives of Oral Biology, 111 (2020) 104646.

  4. Ya-nan Zhu, Yi-ting Zhang, Qin Liu, Shan-mei Shen, Xiang Zou, Yun-xia Cao, Wen-jun Wang, Long Yi, Qian Gao2, Wei-dong Yang1* and Yong Wang. Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women. BMC Medical Genetics (2020) 21:14.  https: //doi.org/10.1186/s12881-019-0945-1.

  5. Rong Wang, Yongzheng Luo, Yadong Lu, Daojuan Wang, Tingyu Wang, Wenyuan Pu, and Yong Wang. Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2. Oxid Med Cell Longev. 2019 Nov 15; 2019: 4703253. doi: 10.1155/2019/4703253.

  6. Wang R,Wang L,Luo Y,Wang D,Du R,Du J,Wang Y.Maggotproteinamelioratesdextransulphatesodium-inducedulcerativecolitisinmice. Biosci Rep.2018 Nov 28;38(6). pii: BSR20181799.

  7. Wang D,Wang W,Liang Q,He X,Xia Y,Shen S,Wang H,Gao Q,Wang Y.DHEA-inducedovarianhyperfibrosisismediatedby TGF-βsignalingpathway.JOvarianRes.2018 Jan 10;11(1):6. doi: 10.1186/s13048-017-0375-7.

  8. Chen XF, Wang L, Wu YZ, Song SY, Min HY, Yang Y, He X, Liang Q, Yi L, Wang Y, Gao Q. Effectofpuerarininpromotingfattyacidoxidationbyincreasingmitochondrialoxidativecapacityandbiogenesisinskeletalmuscleindiabeticrats.Nutr Diabetes.2018 Jan 12;8(1):1. doi: 10.1038/s41387-017-0009-6.

  9. Linghui Kong, Qien Wang, Jiewen Jin, Zou Xiang, Taoyu Chen, Shanmei Shen, Hongwei Wang, Qian Gao, Yong Wang Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells. PLoS One. 2017 Nov 10;12(11):e0188029.

  10. Deng Z,Liu X,Jin J,Xu H,Gao Q,Wang Y,Zhao J. HistoneDeacetylaseInhibitorTrichostatinaPromotestheApoptosisofOsteosarcomaCellsthroughp53SignalingPathwayActivation.Int J Biol Sci.2016;12(11):1298-1308.

  11.  YANJIE XIA, WENQING WANG , LEI WANG , SHANMEI SHEN , YUNXIA CAO , LONG YI, QIAN GAO and YONG WANG, hOGG1 gene polymorphisms and susceptibility to polycystic ovary syndrome, BIOMEDICAL REPORTS 4: 421-426, 2016

  12.  Xiao Huang, Jiewen Jin, Shanmei Shen, Yanjie Xia, Pei Xu, Xiang Zou, Hongwei Wang, Long Yi, Yong Wang & Qian Gao (2015): Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line, Gynecological Endocrinology, 2016;32(3):201-5.

  13.  Yanjie Xia, Shanmei Shen , Xinlin Zhang, Zhantao Deng, Zou Xiang, Hongwei Wang, Long Yi, Qian Gao and Yong Wang, Epigenetic pattern changes in prenatal female Sprague-Dawley rats following exposure to androgen, Reproduction, Fertility and Development2015 Mar 31. doi: 10.1071/RD14292.

  14. Qu J, Che Y, Xu P, Xia Y, Wu X and Wang Y. The higher response of vascular endothelial growth factor and angiotensin-II to human chorionic gonadotropin in women with polycystic ovary syndrome. Int J Fertil Steril 2015 8:373-8

  15. Chen J, Shen S, Tan Y, Xia D, Xia Y, Cao Y, Wang W, Wu X, Wang H, Yi L, Gao Q and Wang Y. The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome. J Ovarian Res 2015 Mar 22;8:11. doi: 10.1186/s13048-015-0139-1.

  16. Wang C, Gao C, Meng K, Qiao H and Wang Y. Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2. PLoS One 2015 Mar 6;10(3):e0119348.

  17. Zhang X, Zhang C, Shen S, Xia Yj, Yi L and Wang Y. Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Hum Reprod 2013 28:3074-85.

承担科研项目[项目负责人]

主持国家自然科学基金面上项目:

1基于TLR4/NF-κB/NETs通路研究NLRP3介导高雄诱导卵泡发育障碍的分子机制 ,81971346202001月至 202312

2发育期高雄激素介导卵巢细胞间去乙酰化酶差异表达在PCOS发病中的机制研究, 81771539, 2018-01-01~2021-12-31.

3p66shc调控PCOS卵巢纤维化病理的机理研究, 81471422, 2015-01-01~2018-12-31.

4PCOS雄激素代谢相关基因的遗传(htSNPs)与表遗传(DNA甲基化)调控机制研究,81170541,2012-01-01~2015-12-31.

5、胰岛素信号系统相关基因多态性与PCOS表型的关系探索,30672228,2007.1.1~2009.12.31.


获奖

2015年获评“本科生教学优秀”;

2016年获评“学生最喜爱的老师”;

2017年获评“本科生教学优秀”;

2016年获评“研究生招生先进个人”;

2019年获评“优秀博士生导师”奖;

2019年获评“南京大学魅力导师”奖;