陈锦飞

文章来源:南京大学医学院发布时间:2019-08-01浏览次数:11

博士研究生导师简介

姓名

陈锦飞

研究方向

消化道肿瘤的基础和临床

联系方式

jinfeichen@sohu.com

学术兼职:

中国临床肿瘤学会理事;中国抗癌协会(CACA)肿瘤热疗专业委员会副主任委员;CACA肿瘤标志专业委员会常务委员、胃癌标志物协助组组长;CACA肿瘤营养专业委员会常务委员;CACA中西医整合肿瘤专业委员会常务委员;CACA精准医学专业委员会常务委员;中国医师协会临床精准治疗专业委员会委员;中国生物技术协会基因检测专业委员会常务委员;中国生物技术协会慢病管理委员会常务委员;等

个人简介

1、学习经历:

11982.09-1987.07:南通大学医学院:临床医学专业,获得学士学位;

22002.09-2003.07:南京医科大学:肿瘤学专业,硕士研究生班;

32004.09-2007.06:东南大学医学院:遗传学专业,博士研究生,获得博士学位

2、工作经历:

11987.08-1999.12:东南大学附属第二医院肿瘤科,医师、主治医师、副主任医师、科主任;

22000.01-2005.04:南京医科大学第二附属医院肿瘤科:副主任医师、主任医师;

32005.05-2007.05:德国乌尔姆大学综合肿瘤科:Research Fellow

42007.07-018.09.30:南京医科大学附属南京医院肿瘤科:主任医师、科主任

52018.10.08-至今:南京大学医学院附属泰康仙林鼓楼医院副院长兼肿瘤肿瘤中心主任。

代表性论文[5年通讯作者和第一作者]

  1. Chu X, Xue Y, Huo X, Wei J, Chen Y, Han R, Chen H, Su X, Zhang H, Gong Y, Chen J. Establishment and characterization of a novel cell line (cc 006cpm8) of moderately/poorly differentiated colorectal adenocarcinoma derived from a primary tumor of a patient. Int J Oncol. 2019 Jul;55(1):243-256. doi: 10.3892/ijo.2019.4806. Epub 2019 May 21.

  2. Ying J, Chen J. Combination versus mono-therapy as salvage treatment for advanced biliary tract cancer: A comprehensive meta-analysis of published data. Crit Rev Oncol Hematol. 2019 Jul;139:134-142. doi: 10.1016/j.critrevonc.2019.01.001. Epub 2019 Jan 4. Review.

  3. Li Z, Yao Z, Zhang Y, Yao J, Pan Z, Chen J. Polyethylenimine (PEI)-Mediated E1A Increases the Sensitivity of Hepatocellular Carcinoma Cells to Chemotherapy. Med Sci Monit Basic Res. 2019 Apr 8;25:113-120.

  4. Jin Y, Zhou K, Zhao W, Han R, Huo X, Yang F, Chen J. Clinicopathological and prognostic significance of metastasis-associated in colon cancer-1 in gastric cancer: A meta-analysis. Int J Biol Markers. 2019 Mar;34(1):27-32. doi: 10.1177/1724600818813634. Epub 2019 Mar 10.

  5. Wei J, Xue Y, Huo X, Han R, Su X, Jin Y, Zhao W, Chen Y, Zhang H, Dai J, Chen J. Establishment and characterization of the GC-030-35 cell line derived from gastric hepatoid adenocarcinoma. Cancer Manag Res. 2019 Feb 8;11:1275-1287. doi: 10.2147/CMAR.S186416. eCollection 2019.

  6. Yao Z, Peng P, Xu D, Zhou X, Pan Z, Li Z, Yao J, Chen J. EGFR inhibitor C225 Increases the Radio-Sensitivity of Human Breast Cancer Cells Asian Pac J Cancer Prev. 2019 Jan 25;20(1):311-319.

  7. Zhao T, Huo X, Chen J. Genetic polymorphism of rs9564966 G > A on 13q22.1 predicts poor survival for Chinese patients with gastric cancer.Cancer Med. 2019 Jan;8(1):428-436. doi: 10.1002/cam4.1693. Epub 2018 Dec 8.

  8. Jin Y, Wu P, Zhao W, Wang X, Yang J, Huo X, Chen J, De W, Yang F. Long noncoding RNA LINC00165-induced by STAT3 exerts oncogenic properties via interaction with Polycomb Repressive Complex 2 to promote EMT in gastric cancer. Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):223-230. doi: 10.1016/j.bbrc.2018.11.012. Epub 2018 Nov 14.

  9. Su X, Xue Y, Wei J, Huo X, Gong Y, Zhang H, Han R, Chen Y, Chen H, Chen J.Establishment and Characterization of gc-006-03, a Novel Human Signet Ring Cell Gastric Cancer Cell Line Derived from Metastatic Ascites. J Cancer. 2018 Sep 7;9(18):3236-3246. doi: 10.7150/jca.26051. eCollection 2018.

  10. Shi J, Chen Y, Chen W, Tang C, Zhang H, Chen Y, Yang X, Xu Z, Wei J, Chen J. Isobavachalcone sensitizes cells to E2-induced paclitaxel resistance by down-regulating CD44 expression in ER+ breast cancer cells. J Cell Mol Med. 2018 Nov;22(11):5220-5230. doi: 10.1111/jcmm.13719. Epub 2018 Sep 4.

  11. Wei X, Zhou J, Hong L, Xu Z, Zhao H, Wu X, Chen J. Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells. Oncol Lett. 2018 Aug;16(2):2135-2142. doi: 10.3892/ol.2018.8900. Epub 2018 Jun 5.

  12. Gu D, Zheng R, Xin J, Li S, Chu H, Gong W, Qiang F, Zhang Z, Wang M, Du M, Chen J. Evaluation of GWAS-Identified Genetic Variants for Gastric Cancer Survival. EBioMedicine. 2018 Jul;33:82-87. doi: 10.1016/j.ebiom.2018.06.028. Epub 2018 Jul 6.

  13. Gu D, Li S, Du M, Tang C, Chu H, Tong N, Zhang Z, Wang M, Chen J. A genetic variant located in the miR-532-5p-binding site of TGFBR1 is associated with the colorectal cancer risk. J Gastroenterol. 2019 Feb;54(2):141-148. doi: 10.1007/s00535-018-1490-y. Epub 2018 Jul 3.

  14. Gu D, Li S, Ben S, Du M, Chu H, Zhang Z, Wang M, Zhang ZF, Chen J. Circadian clock pathway genes associated with colorectal cancer risk and prognosis. Arch Toxicol. 2018 Aug;92(8):2681-2689. doi: 10.1007/s00204-018-2251-7. Epub 2018 Jul 2.

  15. Han R, Wei J, Zhang H, Su X, Chu X, Chen Y, Gong Y, Wang X, Shi J, Chen J. Influence of TS (rs34743033) and RUNX1 (rs2014300) gene polymorphisms on survival outcomes of fluorouracil-based chemotherapy in Chinese advanced gastric cancer patients. Cancer Manag Res. 2018 Jun 6;10:1429-1437. doi: 10.2147/CMAR.S158647. eCollection 2018.

  16. Shi J, Chen Y, Chen Y, Shen Y, Zhao H, Sun H, Chen J. Alloreactive cytotoxic T lymphocyte immunotherapy treatment of a patient with metastatic prostate cancer: A case report. Medicine (Baltimore). 2018 Jun;97(24):e11111. doi: 10.1097/MD.0000000000011111.

  17. Chen Y, Du M, Chen W, Zhu L, Wu C, Zhang Z, Wang M, Chu H, Gu D, Chen J.Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population. Cancer Med. 2018 Apr;7(4):1194-1200. doi: 10.1002/cam4.1409. Epub 2018 Mar 13.

  18. Ji L, Gu D, Tan X, Sun H, Chen J. A meta-analysis of clinical trials over regimens with or without cetuximab for advanced gastric cancer patients. J BUON. 2017 Jul-Aug;22(4):900-904.

  19. Chen Y, Wu Y, Du M, Chu H, Zhu L, Tong N, Zhang Z, Wang M, Gu D, Chen J. An inverse association between tea consumption and colorectal cancer risk. Oncotarget. 2017 Jun 6;8(23):37367-37376. doi: 10.18632/oncotarget.16959.

  20. Chu H, Chen Y, Yuan Q, Hua Q, Zhang X, Wang M, Tong N, Zhang W, Chen J, Zhang Z. The HOTAIR, PRNCR1 and POLR2E polymorphisms are associated with cancer risk: a meta-analysis. Oncotarget. 2017 Jun 27;8(26):43271-43283. doi: 10.18632/oncotarget.14920.

  21. Wei X, Xu Y, Xu FF, Chaiswing L, Schnell D, Noel T, Wang C, Chen J, St Clair DK, St Clair WH. RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells. Cancer Res. 2017 Mar 15;77(6):1345-1356. doi: 10.1158/0008-5472.CAN-16-0785. Epub 2017 Jan 20.

  22. Zhang E, Han L, Yin D, He X, Hong L, Si X, Qiu M, Xu T, De W, Xu L, Shu Y, Chen J.  H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma.Nucleic Acids Res. 2017 Apr 7;45(6):3086-3101. doi: 10.1093/nar/gkw1247.

  23. Zhao T, Xu Z, Gu D, Wu P, Huo X, Wei X, Tang Y, Gong W, He ML, Chen J. The effects of genomic polymorphisms in one-carbon metabolism pathways on survival of gastric cancer patients received fluorouracil-based adjuvant therapy. Sci Rep. 2016 Jul 26;6:28019. doi: 10.1038/srep28019.

  24. Wang M, Gu D, Du M, Xu Z, Zhang S, Zhu L, Lu J, Zhang R, Xing J, Miao X, Chu H, Hu Z, Yang L, Tang C, Pan L, Du H, Zhao J, Du J, Tong N, Sun J, Shen H, Xu J, Zhang Z, Chen J. Common genetic variation in ETV6 is associated with colorectal cancer susceptibility. Nat Commun. 2016 May 5;7:11478. doi: 10.1038/ncomms11478.

  25. Shen L, Wen J, Zhao T, Hu Z, Song C, Gu D, He M, Lee NP, Xu Z, Chen J. A genetic variant in large tumor suppressor kinase 2 of Hippo signaling pathway contributes to prognosis of hepatocellular carcinoma. Onco Targets Ther. 2016 Apr 4;9:1945-51. doi: 10.2147/OTT.S100699. eCollection 2016.

  26. Zhang E, Yin D, Han L, He X, Si X, Chen W, Xia R, Xu T, Gu D, De W, Guo R, Xu Z, Chen J. E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs. Oncotarget. 2016 Apr 26;7(17):23212-26. doi: 10.18632/oncotarget.6745.

  27. Xu Z, Cao C, Xia H, Shi S, Hong L, Wei X, Gu D, Bian J, Liu Z, Huang W, Zhang Y, He S, Lee NP, Chen J. Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma. Front Med. 2016 Mar;10(1):52-60. doi: 10.1007/s11684-016-0433-3. Epub 2016 Jan 25.

  28. Wang Z, Dai J, Hu N, Miao X, Abnet CC, Yang M, Freedman ND, Chen J, Burdette L, Zhu X, Chung CC, Ren C, Dawsey SM, Wang M, Ding T, Du J, Gao YT, Zhong R, Giffen C, Pan W, Koh WP, Dai N, Liao LM, Yan C, Qiao YL, Jiang Y, Shu XO, Chen J, Wang C, Ma H, Su H, Zhang Z, Wang L, Wu C, Xiang YB, Hu Z, Yuan JM, Xie L, Zheng W, Lin D, Chanock SJ, Shi Y, Goldstein AM, Jin G, Taylor PR, Shen H. Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies. Gut. 2017 Apr;66(4):581-587. doi: 10.1136/gutjnl-2015-310612. Epub 2015 Dec 23.

  29. Xu Z, Chen Y, Gu D, Lee NP, Sun S, Gong W, Tan Y, Luk JM, Chen J.SOD2 rs4880 CT/CC genotype predicts poor survival for Chinese gastric cancer patients received platinum and fluorouracil based adjuvant chemotherapy. Am J Transl Res. 2015 Feb 15;7(2):401-10. eCollection 2015.

  30. Zhao T, Wang C, Shen L, Gu D, Xu Z, Zhang X, Xu Y, Chen J. Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies. Onco Targets Ther. 2015 Mar 23;8:649-59. doi: 10.2147/OTT.S76526. eCollection 2015.

  31. Zhao T, Gu D, Xu Z, Huo X, Shen L, Wang C, Tang Y, Wu P, He J, Gong W, He ML, Chen J. Polymorphism in one-carbon metabolism pathway affects survival of gastric cancer patients: Large and comprehensive study. Oncotarget. 2015 Apr 20;6(11):9564-76.

  32. Zhang G, Gu D, Zhao Q, Chu H, Xu Z, Wang M, Tang C, Wu D, Tong N, Gong W, Zhou J, Xu Y, Zhang Z, Chen J. Genetic variation in C12orf51 is associated with prognosis of intestinal-type gastric cancer in a Chinese population. Biomed Pharmacother. 2015 Feb;69:133-8. doi: 10.1016/j.biopha.2014.11.009. Epub 2014 Nov 18.

  33. Ma G, Gu D, Lv C, Chu H, Xu Z, Tong N, Wang M, Tang C, Xu Y, Zhang Z, Wang B, Chen J. Genetic variant in 8q24 is associated with prognosis for gastric cancer in a Chinese population. J Gastroenterol Hepatol. 2015 Apr;30(4):689-95. doi: 10.1111/jgh.12801.

承担科研项目[项目负责人]

1、国家自然科学基金,长链非编码RNA ANRIL SNPs与胃癌氟尿嘧啶类药物敏感性关联研究及其机制探讨,2016/01-2019/1257万元,主持,在研;

2、江苏省重点研发计划,基于多组学特征谱的胃癌分子分型技术和精准诊疗研,2017/07-2020/06200万元,主持,在研;

3、国家自然科学基金,lncRNA HAGLROS通过mTOR信号抑制自噬介导胃癌恶性表型的机制研究,2018/01-2021/1260万元,主持,在研。

获奖情况

  1. 江苏省人政府科学技术进步二等奖 省部级 2015年度;

  2. 中国抗癌协会科技进步三等奖 省部级 2016年度;

3、江苏省医学新技术引进奖 省部级 2015年度。