颜桂军

文章来源:南京大学医学院发布时间:2017-12-05浏览次数:17

南京大学医学院博(硕)士研究生导师简介

姓名

颜桂军

研究方向:

生殖医学

联系方式

Email: yanguijun55@163.com

学术兼职:江苏省发育生物学学会生殖专业委员会常务委员,中国微生物学会科技开发与咨询委员会委员和江苏省医学会男科学分会委员

个人简介

  1. 作简历:美国Rutgers -New Jersey Medical School博士后(2005-2008)2008年南京大学医学院附属鼓楼医院生殖医学科副研究员/副教授,2015年南京大学医学院附属鼓楼医院生殖医学科研究员/博士生导师。


  2. 科研情况简介:主要从事生殖相关领域的基础与临床转化研究,作为项目负责人主持国家自然科学基金项目4项(No.30900727No.81170570No.81370683No.81571402),主持教育部留学回国人员科研启动基金、江苏省“十二五科技兴卫工程”和“十三五科教强卫工程”医学重点人才项目和江苏省“六大高峰人才”等省部级项目4项。在国际知名杂志Circulation ResearchCancer ResearchJ Clin Endocrinol MetabCell Death & Disease等发表SCI论文50余篇。

  3. 研究兴趣:胚胎种植与卵泡发育的调控机制研究


代表性论文

  1.  Mei Zhang(#), Qun Zhang(#), Yali Hu(#), Lu Xu, Yue Jiang, Chunxue Zhang, Lijun Ding, Ruiwei Jiang, Jianxin Sun, Haixiang Sun(*) and Guijun Yan(*), miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation, Cell Death Dis. 2017;8(10):e3088. (*共同通讯作者,SCI IF=5.97)

  2. Chengcai Kong(#), Lihua Sun(#), Mei Zhang(#), Lijun Ding(#), Qun Zhang, Xi Cheng, Zhenyu Diao, Qiang Yan, Hui Zhang, Ting Fang, Xin Zhen, Yali Hu, Haixiang Sun(*), and Guijun Yan(*), miR-133b Reverses the Hydrosalpinx-induced Impairment of Embryo Attachment Through Down-regulation of SGK1, J Clin Endocrinol Metab, 2016 ;101(4):1478-89.(*共同通讯作者,SCI IF=6.31)

  3. Lihua Zhu(#), Lihua Sun(#), Yali Hu(#), Yue Jiang, Hongyu Liu, Xiaoyue Shen, Xiaoyan Jin, Xin Zhen, Haixiang Sun(*), andGuijun Yan(*), PCAF Impairs Endometrial Receptivity and Embryo Implantation by Down-Regulating β3-Integrin Expression via HOXA10 Acetylation, J Clin Endocrinol Metab, 2013, 98(11):4417-4428. (*共同通讯作者,SCI IF=6.31)

  4. Haixiang Sun(#), Deyi Zeng(#), Ruotian Li(#), Ruiping Pang(#), Hui Yang, Yali Hu, Qun Zhang, Yue Jiang, Linyan Huang, Yongbo Tang, Guijun Yan(*), and Jiaguo Zhou(*),Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase,Hypertension,2012, 60:1407-1414. (*共同通讯作者SCI IF=6.873)

  5. Ruiwei Jiang(#), Lijun Ding(#), Jianjun Zhou(#), Chenyang Huang, Qun Zhang, Yue Jiang, Jingyu Liu, Qiang Yan, Xin Zhen, Jianxin Sun, Guijun Yan(*) and Haixiang Sun(*), Enhanced HOXA10 sumoylation inhibits embryo implantation in women with recurrent implantation failure, Cell Death Discov. 2017 Oct 9;3:17057. (*共同通讯作者)

  6. Yue Jiang(#), Qun Zhang(#), Yali Hu(#), Hui Zhang1, Yun Cao1, Mei Zhang1, Junxia Wang, Lijun Ding, Zhenyu Diao, Haixiang Sun(*), Guijun Yan(*).decreased expression of NR4A nuclear receptors in adenomyosis impairs endometrial decidualization. Molecular Human Reproduction.2016, 22(9):655-68. (*共同通讯作者SCI IF=3.943)

  7. Lu Xu(#), Haixiang Sun(#), Mei Zhang(#), Yue Jiang, Chunxue Zhang, Jianjun Zhou, Lijun Ding, Yali Hu(*), Guijun Yan(*). MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4,Mol Cell Endocrinol. 2017;452:138-147. (*共同通讯作者SCI IF=3.75)

  8. Guangfeng Zhao(#),Guijun Yan(#), Jie Cheng, Xue Zhou, Ting Fang, Haixiang Sun, Yayi Hou(*), and Yali Hu(*). Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.Sci Rep, 2015, 5: 7647. (#共同第一作者, SCI IF=5.078)

  9. Guijun Yan(#), Ni Zhu(#), Shengdong Huang, Bing Yi, Xiying Shang, Ming Chen, Nadan Wang, Guan-xin Zhang, Jennifer A Talarico, Douglas G. Tilley, Erhe Gao, Jianxin Sun(*), Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation, Mol Cell Biol, 2015, 35(19):3312-23. (#共同第一作者, SCI IF=4.43)

  10. Guijun Yan(#), Fei Yu(#), Bin Wang, Huaijun Zhou, Qiuyan Ge, Jing Su, Yali Hu, Haixiang Sun(*), and Lijun Ding(*), MicroRNA miR-302 inhibits the tumorigenicity of endometrial cancer cells by suppression of Cyclin D1 and CDK1, Cancer Lett, 2014, 345(1):39-47. (#共同第一作者,SCI IF=5.016)

  11. Guijun Yan(#), Qing Qin(#), Bing Yi, Kurt Chuprun, Haixiang Sun, Shengdong Huang, and Jianxin Sun(*), Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1, Int J Cardiol, 2013, 168(4):3291-3299. (#共同第一作者,SCI IF=6.1890)


承担科研项目

  1. 国家自然科学基金面上项目:锌指蛋白KLF12转录抑制SPHK1调控卵巢颗粒细胞凋亡与卵泡发育的机制研究,60万(No.81571402

  2. 国家自然科学基金面上项目miR-181a调控Foxo1乙酰化修饰在颗粒细胞凋亡及卵泡发育中的机制研究,70万  (No.81370683)  

  3. 国家自然科学基金面上项目:孤儿核受体Nur77影响子宫内膜异位症胚胎植入的机制研究,58万  (No.81170570)

  4. 国家自然科学基金青年项目:MST1参与调控子宫内膜间质细胞蜕膜化分子机制研究,20万  (No.30900727)  

  5. 江苏省十三五强卫工程医学重点人才项目:锌指蛋白KLF12与女性不孕的机制研究50万(ZDRCA2016070

  6. 江苏省十二五科技兴卫工程医学重点人才项目:子宫内膜异位症中孤儿核受体NR4A亚家族影响胚胎植入的机制研究,50万(RC2011005

  7. 教育部留学回国人员科研启动基金:MST1通过磷酸化HOXA10参与调控子宫内膜间质细胞蜕膜化研究,5

  8. 江苏省六大人才高峰项目:MST1NR4A1相互作用影响子宫内膜间质细胞体外蜕膜化的机制研究 3