张 鑫

文章来源:南京大学医学院发布时间:2017-12-05浏览次数:858

博士研究生导师简介

姓名

张鑫

研究方向:

脑血管病基础与临床

联系方式

13851879970


学术兼职:中国医师协会神经介入专业委员会委员;中国脑防委外科专业委员会常务委员;江苏省卒中学会神经介入专业委员会副主任委员;江苏省医学会神经外科分会委员;江苏省介入医学分会委员兼神经介入学组组长;中国人民解放军神经外科专业委员会神经介入专业组委员;南京军区介入医学专业委员会委员;中国卒中学会神经介入分会青年委员;中国抗衰老促进会神经系统疾病专业委员会委员;中国研究型医院学会脑血管病学专业委员会委员;中国生物医学工程学会介入医学工程分会神经介入学组委员;


个人简介

主任医师,教授,博士生导师,博士后导师

解放军南京总医院神经外科副主任、神经介入中心主任,中国医师协会神经介入专业委员会委员,江苏省医学会神经外科分会委员,江苏省医学会介入分会委员兼神经介入组组长,《中国脑血管病杂志》等杂志编委,江苏省“科教强卫”重点人才,江苏省六大人才高峰培养对象,获江苏省新技术引进奖一等奖,全军科技进步奖三等奖,累计主持国家自然基金等外源性课题5项,发表文章60余篇(SCI 18篇),对颅内动脉瘤、动静脉畸形、硬脑膜动静脉瘘等脑血管疾病的诊断治疗有丰富临床经验,每年完成各类脑血管疾病的介入治疗600余例,病例数居全国前列。



代表性论文[5年通讯作者和第一作者]

  1.  Xiangsheng Zhanga,, Qi Wu,Yue Lua,1, Jieru Wanb, Haibin Daia, Xiaoming Zhoud,Shengyin Lvc, Xuemei Chene, Xin Zhang(通讯作者),, Chunhua Hanga, Jian Wangb.Cerebroprotection by salvianolic acid B after experimental subarachnoidhemorrhage occurs via Nrf2- and SIRT1-dependent pathways. Free Radical Biology and Medicine.2018(124):504-516

  2.  Sheng-yin Lv, Qi Wu, Jing-peng Liu, Jiang Shao, Li-li Wen, Jin Xue, Xiang-sheng Zhang, Qing-rong Zhang, Xin Zhang(通讯作者). Levels of Interleukin-1b, Interleukin-18, and Tumor Necrosis Factor-a in Cerebrospinal Fluid of Aneurysmal Subarachnoid Hemorrhage Patients May Be Predictors of Early Brain Injury and Clinical Prognosis. WORLD NEUROSURGERY,2018,111(e362-373).

  3. Jing CaiXin Zhang(通讯作者)et al. Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury。  Journal of Physiology and Biochemistry  DOI: 10.1007/s13105-018-0617-1

  4.  Xiangsheng Zhang, Qi Wu1, Qingrong Zhang, Yue Lu,  Jingpeng Liu,  Wei Li,  Shengyin Lv,  Mengliang Zhou, Xin Zhang(通讯作者) and Chunhua Hang. Resveratrol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage via Inhibition of NLRP3 Inflammasome Activation. Frontiers in Neuroscience,2017,11, doi: 10.3389/fnins.2017.00611.

  5.  Li-Li Wen, Xin Zhang(通讯作者), Qing-Rong Zhang, Qi Wu, Shu-Juan Chen,Jin-Long Deng, Kaiyi Huang, Han-Dong Wang. Flat-detector computed tomography PBV map in the evaluation of presurgical embolization for hypervascular brain tumors. J NeuroIntervent Surg. 2016-012658.

  6.  Xiang-Sheng Zhang, Qi Wu, Ling-Yun Wu, Zhen-Nan Ye, Tian-Wei Jiang, Wei Li, Zong Zhuang, Meng-Liang Zhou, Xin Zhang(通讯作者), Chun-Hua Hang. Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats. Cell Death and Disease. 2016, 7e2416.

  7.  Xiang-Sheng Zhang, Wei Li, Qi Wu, Ling-Yun Wu, Zhen-Nan Ye, Jing-Peng Liu, Zong Zhuang, Meng-Liang Zhou, Xin Zhang(通讯作者), Chun-Hua Hang. Resveratrol Attenuates Acute Inflammatory Injury in Experimental Subarachnoid Hemorrhage in Rats via Inhibition of TLR4 Pathway. International Journal of Molecular Sciences. 2016,17e1331.

  8.  Qi Wu, Xiao-liang Wang, Qing Yu, Hao Pan, Xiang-sheng Zhang, Qing-rong Zhang, Han-dong Wang, Xin Zhang(通讯作者). Inflammasome Proteins in Cerebrospinal Fluid of Patients with Subarachnoid Hemorrhage are Biomarkers of Early Brain Injury and Functional Outcome. World Neurosurgery,2016,94:472-479.

  9.  Qi Wu, Xiang-sheng Zhang, Han-dong Wang, Qing-rong Zhang, Li-li Wen, Chun-hua Hang, Xin Zhang(通讯作者). Onyx Embolization for Tentorial Dural Arteriovenous Fistula with Pial Arterial Supply: Case Series and Analysis of Complications. World Neurosurgery,2016,92(8):58-64.

  10.  Xiang-Sheng Zhang, Xin Zhang(通讯作者), Qing-RongZhang, Qi Wu, Wei Li, Tian-Wei Jiang, Chun-Hua Hang. Astaxanthin reduces matrix metalloproteinase-9 expression and activity in the brain after experimental subarachnoid hemorrhage in rats. Brain Research2015162422):113-124.

  11.  Qi Wu, Xiang-Sheng Zhang, Han-Dong Wang,*, Xin Zhang(通讯作者),*, Qing Yu , Wei Li, Meng-Liang Zhou and Xiao-Liang Wang. Astaxanthin Activates Nuclear Factor Erythroid-Related Factor 2 and the Antioxidant Responsive Element (Nrf2-ARE) Pathway in the Brain after Subarachnoid Hemorrhage in Rats and Attenuates Early Brain Injury. Mar. Drugs 2014

  12. Xiang-Sheng Zhang, Xin Zhang(通讯作者)  Qi WuWei LiQing-Rong ZhangChun-Xi WangXiao-Ming ZhouHua LiJi-Xin Shi and Meng-Liang Zhou *. Astaxanthin Alleviates Early Brain Injury Following Subarachnoid Hemorrhage in Rats: Possible Involvement of Akt/Bad Signaling Astaxanthin Alleviates Early Brain Injury Following Subarachnoid Hemorrhage in Rats: Possible Involvement of Akt/Bad Signaling. Mar. Drugs 2014, 12(8), 4291-4310.

  13. Zhang XSZhang X(通讯作者)Wu QLi WWang CXXie GBZhou XMShi JXZhou ML. Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage. J Surg Res. 2014;192(1):206-213.

  14. Qi Wu, Han-dong Wang, Yong Sam Shin, Xin Zhang(通讯作者). Brainstem Congestion Due to Dural Ateriovenous Fistula at the Craniocervical Junction, J Korean Neurosurg Soc. 2014;55(3):152-155.

  15. Xiang-Sheng Zhang, Xin Zhang(通讯作者), Meng-Liang Zhou, Xiao-Ming Zhou, Ning Li, Wei Li, Zi-Xiang Cong, Qing Sun, Zong Zhuang, Chun-Xi Wang, and Ji-Xin Shi . Amelioration of oxidative stress and protection against early brain injury by astaxanthin after experimental subarachnoid hemorrhage. Laboratory investigation. Journal of Neurosurgery. 2014;121(1):42-54.

  16. Xiao-Ming Zhou, Meng-Liang Zhou, Xiang-Sheng Zhang, Zong Zhuang, Tao Li Ji-Xin Shi, Xin Zhang(通讯作者). Resveratrol prevents neuronal apoptosis in an early brain injury model. Journal of surgical research20141892014):159-165.

  17. Xiao-Ming Zhou, Xin Zhang(通讯作者), Xiang-Sheng Zhang, Zong Zhuang, Wei Li, Qing Sun, Tao Li, Chun-Xi Wang, Lin Zhu, Ji-Xin Shi, and Meng-Liang Zhou.SIRT1 Inhibition by Sirtinol Aggravates Brain Edema After Experimental Subarachnoid Hemorrhage. Journal of Neuroscience Research 2014(92):714-722.

  18. 吴琪,张鑫(通讯作者),张庆荣,文立利,张翔圣,薛锦,陈姝娟,邓金龙,薛锦。支架辅助弹簧圈栓塞治疗大脑前A1段动脉瘤分析。医学研究生报。2018,316):613-616

  19. 文立利,张鑫(通讯作者),张庆荣,吴琪,陈姝娟,邓金龙,吕盛银,邵将,王汉东。双血管融合技术在复杂前交通动脉瘤介入治疗中的应用。医学研究生报。2018,324):404-407

  20. 文立利,张鑫(通讯作者),张庆荣,吴琪,陈姝娟,邓金龙,吕盛银,邵将,王汉东。重叠低剖面可视化腔内支撑装置治疗颈内动脉血泡样动脉瘤的疗效分析。医学研究生报。2018.323):235-238

  21. 吴琪,张鑫(通讯作者),张庆荣,文立利,张翔圣,薛锦,陈姝娟,邓金龙,王汉东。支架辅助弹簧圈栓塞治疗大脑前远端动脉瘤的疗效分析。医学研究生报。2018313):239-243

  22. 凌海平,张鑫(通讯作者),张庆荣,吴琪,文立利,陈姝娟,邓金龙,王汉东。脑室外引流在重症破裂动脉瘤患者支架辅助栓塞治疗后的安全性分析。医学研究生报。2018,313):244-248

  23. 张庆荣,张鑫(通讯作者),吴琪 文立利,张翔圣,薛锦,陈姝娟,邓金龙,王汉东。支架辅助技术在出血性椎动脉夹层动脉瘤治疗中的应用。医学研究生报,2018313):249-253.

  24. 薛锦,陈姝娟,文立利,张翔圣,吕盛银,邓金龙,吴琪,张庆荣,王汉东,张鑫(通讯作者)。支架辅助弹簧圈栓塞颅内破裂宽颈囊性动脉瘤的并发症及预后影响因素分析。中华神经外科杂志,2017334:339-343.

  25. 张翔圣,张鑫(通讯作者),张庆荣,吴琪,文立利,茅磊,吴伟,杭春华。MRI3D-DSA融合技术在脑动静脉畸形手术的应用研究。中华神经外科疾病杂志,2016154):334-337

  26. 文立利,张鑫(通讯作者),张庆荣,吴琪,张翔圣,杭春华,史继新,王汉东。大脑中动脉瘤的血管内栓塞及预后。中国脑血管病杂志,2016,132):57-61

  27. 张翔圣,张鑫(通讯作者),张庆荣,吴琪,文立利,茅磊,吴伟,杭春华。三维DSAMRICT融合技术在颅内动静脉畸形治疗中的应用价值。中国脑血管病杂志,2015,129):449-455

  28. 文立利,张鑫(通讯作者),张庆荣,吴琪,张翔圣,茅磊,吴伟,杭春华,王汉东。彩色血流编码图对颅内动静脉畸形评估的价值。中国脑血管病杂志,2015,128):415-420

  29. 张翔圣,张鑫(通讯作者),张庆荣,吴琪,陈姝娟。血栓弹力图对支架辅助颅内栓塞动脉瘤不同剂量抗血小板聚集药物疗效的初步评价。中国脑血管病杂志,2015,123):130-133,159

  30. 张翔圣,范杰梅,张鑫(通讯作者),李伟,张庆荣,吴琪。虾青素在兔蛛网膜下腔出血后的保护作用研究。中华神经外科疾病研究杂志,2015141):18-21

  31. 张庆荣,范杰梅,吴琪,张翔圣,张鑫(通讯作者)。经动脉入路球囊栓塞治疗48例创伤性颈内动脉海绵窦瘘。中国微侵袭神经外科杂志,2015,205):217-218

  32. 吴琪,张鑫(通讯作者),张庆荣,王汉东,杭春华,史继新。ONYX闭塞载瘤动脉治疗颅内远端动脉瘤的随访分析。中国脑血管病杂志,2014,114):192-195.

  33. 张翔圣,张鑫(通讯作者),周晓明,李伟,周孟良,励宁,王友伟。虾青素对大鼠蛛网膜下腔出血后早期脑损伤的保护作用。中华实验外科杂志,2014,312):325-327




承担科研项目[项目负责人]

  1. 虾青素纳米载药颗粒在蛛网膜下腔出血后脑微循环障碍中的保护作用及机制研究”国家自然科学基金面上项目(2015.01-2018.12 ) 项目负责人:张鑫(科研经费:70万)

  2. 蛛网膜下腔出血后早期脑损伤的多模型机制研究与多模态损伤评估”江苏省“科教强卫”重点人才项目(2016.01-2020.12)项目负责人:张鑫(科研经费100万)

  3. 虾青素纳米载药颗粒在脑外伤后继发脑损伤的保护作用及机制研究”南京军区医药卫生科研基金项目(2016.01-2018.12)项目负责人:张鑫(科研经费5万)



获奖情况

 2014年  江苏省医学新技术引进奖   一等奖

 2014年  南京总院优秀带教老师

 2016年  军队三等功

 2016年  军队科学技术进步奖    三等奖

 2017年  南京总院优秀教师