张 鑫

文章来源:南京大学医学院发布时间:2017-12-05浏览次数:12

南京大学医学院博(硕)士研究生导师简介

姓名

张鑫

研究方向:

脑血管病的基础与临床研究

联系方式

电话:

Email: zhangxsp@163.com

学术兼职:

1.中国医师协会神经介入专业委员会委员

2.中国脑防委外科专业委员会常务委员

3.江苏省卒中学会神经介入专业委员会副主任委员

4.江苏省医学会神经外科分会委员

5.江苏省神经外科分会神经介入学组筹备组组长

6.江苏省介入医学分会委员兼神经介入组组长

7.中国人民解放军神经外科专业委员会神经介入专业组委员

8.南京军区介入医学专业委员会委员

9.中国卒中学会神经介入分会青年委员


个人简介


    医学博士,南京总医院神经外科主任医师,全军神经外科研究所神经介入中心主任,南京大学、南方医科大学博士生导师,博士后导师,第二军医大学兼职教授,第二军医大学、南京医科大学、东南大学、江苏大学及南京工业大学硕士研究生导师,《中国脑血管病杂志》编委、《中华实验外科杂志》编委、《微侵袭神经外科杂志》审稿专家。1999年开始从事神经介入的临床与基础工作,在脑血管疾病介入诊断、治疗方面积累了丰富的经验,对复杂的颅内动脉瘤、脑动静脉畸形及硬膜动静脉瘘等的栓塞治疗有深入的研究。每年完成各类脑血管疾病的介入治疗600余例,以第一或通讯作者共发表文章50余篇(其中SCI 15篇)。江苏省“科教强卫”重点人才,江苏省六大人才高峰培养对象,作为第一负责人主持国家自然基金等外源性课题5项(经费138万),2014年获江苏省新技术引进奖一等奖。2016年获全军医疗成果三等奖。


代表性论文

1. Zhang X, Wu Q, Zhang Q, Lu Y, Liu J, Li W, Lv S, Zhou M, Zhang X(通讯作者), Hang C: Resveratrol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage via Inhibition of NLRP3 Inflammasome Activation. Frontiers in Neuroscience 2017, 11.

2. Zhang, X.S.; Wu, Q.; Wu, L.Y.; Ye, Z.N.; Jiang, T.W.; Li, W.; Zhuang, Z.; Zhou, M.L.; Zhang, X(通讯作者); Hang, C.H. Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats. Cell Death Dis 2016, 7, e2416.

3. Zhang, X.S.; Li, W.; Wu, Q.; Wu, L.Y.; Ye, Z.N.; Liu, J.P.; Zhuang, Z.; Zhou, M.L.; Zhang, X(通讯作者); Hang, C.H. Resveratrol attenuates acute inflammatory injury in experimental subarachnoid hemorrhage in rats via inhibition of tlr4 pathway. Int J Mol Sci 2016, 17, e1131.

4. Wen, L.L.; Zhang, X(通讯作者); Zhang, Q.R.; Wu, Q.; Chen, S.J.; Deng, J.L.; Huang, K.; Wang, H.D. Flat-detector computed tomography pbv map in the evaluation of presurgical embolization for hypervascular brain tumors. J Neurointerv Surg 2016

5. Qi Wu, Xiao-liang Wang, Qing Yu, Hao Pan, Xiang-sheng Zhang, Qing-rong Zhang, Han-dong Wang, Xin Zhang(通讯作者) Inflammasome Proteins in Cerebrospinal Fluid of Patients with SubarachnoidHemorrhage are Biomarkers of Early Brain Injury and Functional Outcome. World Neurosurgery,2016,94:472-479.

6. Qi Wu, Xiang-sheng Zhang, Han-dong Wang, Qing-rong Zhang, Li-li Wen, Chun-hua Hang, Xin Zhang(通讯作者)Onyx Embolization for Tentorial Dural Arteriovenous Fistula with Pial Arterial Supply: Case Series and Analysis of Complications. World Neurosurgery,2016,92(8):58-64.

7. Xiang-Sheng Zhang,Xin Zhang(通讯作者)Qing-RongZhang, Qi Wu, Wei Li, Tian-Wei Jiang,Chun-Hua Hang. Astaxanthin reduces matrixmetalloproteinase-9 expression and activityin the brain after experimental subarachnoidhemorrhage in rats. Brain Research2015162422:113-124.

8. Qi Wu, Xiang-Sheng Zhang, Han-Dong Wang, Xin Zhang(通讯作者), Qing Yu , Wei Li, Meng-Liang Zhou and Xiao-Liang Wang. Astaxanthin Activates Nuclear Factor Erythroid-Related Factor 2 and the Antioxidant Responsive Element (Nrf2-ARE) Pathway in the Brain after Subarachnoid Hemorrhage in Rats and Attenuates Early Brain Injury. Mar. Drugs 201412(12):6125-6141.

9. Xiang-Sheng ZhangXin Zhang(通讯作者) Qi WuWei LiQing-Rong ZhangChun-Xi WangXiao-Ming ZhouHua LiJi-Xin Shi and Meng-Liang Zhou *. Astaxanthin Alleviates Early Brain Injury Following Subarachnoid Hemorrhage in Rats: Possible Involvement of Akt/Bad Signaling Astaxanthin Alleviates Early Brain Injury Following Subarachnoid Hemorrhage in Rats: Possible Involvement of Akt/Bad Signaling. Mar. Drugs 2014, 12(8), 4291-4310.

10.Zhang XS, Zhang X(通讯作者) Wu QLi WWang CXXie GBZhou XMShi JXZhou ML. Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage. J Surg Res. 2014;192(1):206-213.

11. Qi Wu, Han-dong Wang, Yong Sam Shin,Xin Zhang.(通讯作者)Brainstem Congestion Due to Dural Ateriovenous Fistula at the Craniocervical Junction, J Korean Neurosurg Soc. 2014;55(3):152-155.

12. Xiang-Sheng Zhang,Xin Zhang(通讯作者)Meng-Liang Zhou, Xiao-Ming Zhou, Ning Li, Wei Li, Zi-Xiang Cong, Qing Sun, Zong Zhuang, Chun-Xi Wang, and Ji-Xin Shi . Amelioration of oxidative stress and protection against early brain injury by astaxanthin after experimental subarachnoid hemorrhage. Laboratory investigation. Journal of Neurosurgery.2014;121(1):42-54.

13. Xiao-Ming Zhou, Meng-Liang Zhou, Xiang-Sheng Zhang, Zong Zhuang, Tao Li Ji-Xin Shi, Xin Zhang(通讯作者)Resveratrol prevents neuronal apoptosis in an early brain injury model. Journalof surgical research20141892014):159-165.

14. Xiao-Ming Zhou, Xin Zhang(通讯作者)Xiang-Sheng Zhang, Zong Zhuang, Wei Li, Qing Sun, Tao Li, Chun-Xi Wang, Lin Zhu, Ji-Xin Shi, and Meng-Liang Zhou.SIRT1 Inhibition by Sirtinol Aggravates Brain Edema After Experimental Subarachnoid Hemorrhage. Journal of Neuroscience Research 2014(92):714-722.

15. Qi Wu, Han dong Wang, Qing rong Zhang, Xin Zhang(通讯作者)Parent artery occlusion with Onyx for distal aneurysms of posterior inferior cerebellar artery: A single centre experience in a series of 15 patients. Neurology India .May-Jun 2013, 61(3):265-269.

承担科研项目

  1. 虾青素纳米载药颗粒在蛛网膜下腔出血后脑微循环障碍中的保护作用及机制研究-国家自然科学基金面上项目(课题经费:70万)

  2. 虾青素纳米载药颗粒在蛛网膜下腔出血后脑微循环功能障碍中的保护作用及机制研究-江苏省自然科学基金面上项目(课题经费:10万)

  3. 蛛网膜下腔出血后早期脑损伤的多模型机制研究与多模态损伤评估-江苏省“科教强卫”重点人才(经费100万)

  4. 虾青素纳米载药颗粒在脑外伤后继发脑损伤的保护作用及机制研究-军区课题面上项目(课题经费5万)