孙海翔

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:3

 

士研究生导师简介

姓名

孙海翔

研究方向

生殖医学

 

专业:

妇产科学

联系方式

Mailstevensunz@163.com

学术兼职:
江苏省妇产科学会副主任委员,中华医学会生殖医学分会委员兼生殖实验室学组副组长,南京市计划生育学会候任主任委员

个人简介

1.工作简历

  1987.8-1992.7   扬州大学医学院附属苏北医院  住院医师

  1995.12-2000.7  扬州大学医学院附属苏北医院  主治医师

  2000.7-2001.5   扬州大学医学院附属苏北医院   副主医师

2001.5-2006.12  南京大学医学院附属鼓楼医院  副主医师/副教授

2007.01-2009.12  南京大学医学院附属鼓楼医院 医师

2009.12-至今    南京大学医学院附属鼓楼医院   医师/教授、博导

 

2.科研情况简介

 主要从事胚胎种植的分子机制研究和卵泡发育调控的临床与基础研究。近5年在国内外期刊上发表论文100余篇,其中SCI论文近30篇,主编/副主编专业书2部,参编专业书4部。近5年主持国家自然科学基金项目1项,作为学术骨干参加国家重点基础研究发展计划(973项目)项目1项,主持江苏省“十二五科技兴卫工程”创新团队和领军人才项目1项,江苏省临床医学科技专项1项和江苏省自然科学基金项目2项。 

 

代表性论文

1.Yan GJ, Yu F, Wang B, Zhou HJ, Ge QY, Su J, Hu YL, Sun HX*, Ding LJ*. MicroRNA miR-302 inhibits the tumorigenicity of endometrial cancer cells by suppression of Cyclin D1 and CDK1. Cancer Lett. 2014 Apr 1;345(1):39-47. (SCI IF=5.016)

 * Co-Corresponding author

2Jiang Y, Yan G, Zhang H, Shan H, Kong C, Yan Q, Xue B, Diao Z, Hu Y*, Sun H*. Activation of matrix metalloproteinase-26 by HOXA10 promotes embryo adhesion in vitro. Biochem Biophys Res Commun. 2014;445(3):622-8. SCI IF=2.548

* Co-Corresponding author

3. Zhu LH, Sun LH, Hu YL, Jiang Y, Liu HY, Shen XY, Jin XY, Zhen X, Sun HX*, Yan GJ*. PCAF Impairs Endometrial Receptivity and Embryo Implantation by Down-Regulating β3-Integrin Expression via HOXA10 Acetylation. J Clin Endocrinol Metab. 2013;98(11):4417-28. SCI IF=6.43 *Co-Corresponding author

4. Yan G, Qin Q, Yi B, Chuprun K, Sun H, Huang S, Sun J. Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1. Int J Cardiol. 2013 Oct 9;168(4):3291-9.( SCI IF=5.09)

5. Zhang Q, Sun HX, Jiang Y, Ding LJ, Wu SG, Fang T, Yan GJ, Hu YL. MicroRNA-181a Suppresses Mouse Granulosa Cell Proliferation by Targeting Activin Receptor IIA. PLoS One. 2013; 8(3):e59667.( SCI IF=4.092)

6. Anyi Dai, Haixiang Sun, Ting Fang, Qun Zhang, Shaogen Wu, Yue Jiang, Lijun Ding, Guijun Yan, Yali Hu. MicroRNA-133b Stimulates Ovarian Estradiol Synthesis by Targeting Foxl2. FEBS Lett. 2013;587(15):2474-82.  (SCI IF=3.538)

7. Li R, Yan G, Zhang Q, Jiang Y, Sun H, Hu Y, Sun J, Xu B. miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. FEBS Lett , 2013; 587(12): 1754-1761. (SCI IF=3.538)

8. Shen XY, Hu YL, Jiang Y, Liu HY, Zhu LH, Jin XY, Shan HZ, Zhen X, Sun LH*, Yan GJ*, Sun HX. Krüppel-like factor 12 negatively regulates human endometrial stromal cell decidualization. Biochem Biophys Res Commun. 2013, 29;433(1):11-7. SCI IF=2.548*Co-Corresponding author

9. Liu H, Jiang Y, Jin X, Zhu L, Shen X, Zhang Q, Wang B, Wang J, Hu Y, Yan G*, Sun H*. CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity. Reprod Biol Endocrinol. 2013;11:64. SCI IF=2.144* Co-Corresponding author

10. He QY, Ding LJ, Sun HX, Dai AY, Yan GJ, Wang B, Hu YL. FSH modulates the expression of inhibin-α and the secretion of Inhibins via orphan nuclear receptor Nur77 in ovarian granulosa cells. Mol Reprod Dev. 2013 ;80(9):734-43.SCI IF=2.812

11. Ding LJ, Wang B, Shen XY, Yan GJ, Zhang NY, Hu YL, Sun HX*. Withdrawal of GnRH agonist decreases oestradiol and VEGF concentrations in high responders. Reprod Biomed Online. 2013 ;27(2):131-9.SCI IF=2.675Corresponding author

 

12.H Sun, D Zeng, R Li, R Pang, H Yang, Y Hu, Q Zhang, Y Jiang, L Huang, Y Tang, G Yan, Ji Zhou. Essential role of microRNA-155 in regulating endothelium- dependent vasorelaxation by targeting endothelial nitric oxide synthase. Hypertension. 2012; 60(6):1407-14.SCI IF=6.207

13. Li X*, Sun H*, Lin N, Hou X, Wang J, Zhou B, Xu P, Xiao Z, Chen B, Dai J, Hu Y. Regeneration of uterine horns in rats by collagen scaffolds loaded with collagen-binding human basic fibroblast growth factor. Biomaterials. 2011;32(32):8172-81. (*equally contributedSCI IF=7.404)

14. Dai A, Yan G, He Q, Jiang Y, Zhang Q, Fang T, Ding L, Sun J, Sun H*, Hu Y*. Orphan nuclear receptor nur77 regulates androgen receptor gene expression in mouse ovary. PLoS One. 2012;7(6):e39950. Co-Corresponding authorSCI IF=4.092

15. Yan G, Zhang L, Fang T, Zhang Q, Wu S, Yue J, Sun H*, Hu Y*. MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB. FEBS Lett. 2012;586(19):3263-3270 Co-Corresponding authorSCI IF=3.538

16. Jiang Y, Hu YL, Zhao J, Zhen X, Yan GJ*, Sun HX*. The orphan nuclear receptor Nur77 regulates decidual prolactin expression in human endometrial stromal cells. Biochemical and Biophysical Research Communications. 2011;404 (2):628-33Co-Corresponding authorSCI IF=2.595

17. Ding LJ, Yan GJ, Ge QY, Yu F, Zhao X, Diao ZY, Wang ZQ, Yang ZZ, Sun HX*, Hu YL*. FSH acts on the proliferation of type A spermatogonia via Nur77 that increases GDNF expression in the Sertoli cells. FEBS Lett. 2011;585(15):2437-44. Co-Corresponding authorSCI IF=3.538

18. Sun H, Chen LJ, Yan GJ, Wang R, Diao ZY, Hu YL, Li CJHOXA10 suppresses p/CAF promoter activity via three consecutive TTAT units in human endometrial stromal cells. Biochemical and Biophysical Research Communications.2009379 :16–21 SCI IF=2.595

19. Zhang X, Ding L, Diao Z, Yan G, Sun H, Hu Y. CYR61 Modulates the Vascular Endothelial Growth Factor C Expression of Decidual NK Cells Via PI3K/AKT Pathway. Am J Reprod Immunol. 2012; 67(3):216-23. SCI IF=3.05

Zhang XYan G, Diao Z, Sun H, Hu Y. NUR77 inhibits the expression of TIMP2 and increases the migration and invasion of HTR-8/SVneo cells induced by CYR61.Placenta. 2012;33(7):561-7. SCI IF=3.693

20. Dai Y, Diao Z, Sun H, Li R, Hu Y.. MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR-8/SVneo cells induced by lipopolysaccharides. Hum Reprod. 2011; 26(7):1882-91. SCI IF=4.475

21. Li R, Yan G, Li Q, Sun H, Hu Y, Sun J, Xu B. MicroRNA-145 Protects Cardiomyocytes Against Hydrogen Peroxide (H2O2)-induced Apoptosis Through Targeting The Mitochondria Apoptotic Pathway. PLoS One. 2012;7(9): e44907. SCI IF=4.092

22. Zhou JJ, Wang ZQ, Zhao X, Wang JX, Sun HX, Hu YL . An increase of Treg cells in the peripheral blood is associated with a better in vitro fertilization treatment outcome. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY.  2012; 68(2):100-106. (SCI IF=3.05)

23. Dai YM, Diao ZY, Sun HX, Li RT, Qiu ZH, Hu YL. MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR-8/SVneo cells induced by lipopolysaccharides. HUMAN REPRODUCTION. 2011; 26(7): 1882-1891. (SCI IF=4.475)

24. Sun J, Fan HJ, Che YN, Cao YX, Wu XK, Sun HX, Liang FJ, Yi L, Wang Y. Association between ACE gene I/D polymorphisms and hyperandrogenism in women with Polycystic Ovary Syndrome (PCOS) and controls. BMC MEDICAL GENETICS. 2009; 10:64. (SCI IF=2.328)

 

承担课题

1国家自然科学基金面上项目:半胱氨酸蛋白酶CAPN7影响子宫内膜异位症胚胎植入的机制研究,32万,结题。(No.81070492)

2、江苏省医学领军人才项目:提高体外受精-胚胎移植技术临床成功率的个体化综合策略研究,300万,在研。(LJ201102

3、江苏省自然科学基金项目:乙酰转移酶p/CAF影响子宫内膜异位症胚胎着床的机制研究,8万,结题。(NO.BK2009038)

4、江苏省六大人才高峰项目:半胱氨酸蛋白酶CAPN7影响子宫膜异位症胚胎粘附和侵入的机制研究,3万,在研。(No.2010-WS-058)

5、江苏省妇幼重点学科项目,30万,在研。(FXK 201301014.01-2016.12

6、江苏省妇幼重点人才项目:准确评估胚胎着床潜能的方法建立与临床应用,     在研。F201318  2014.01-2016.12          

7、江苏省第四期“333高层次人才培养工程项目:锌指蛋白KLF12调控胚胎种植的机制研究,5万,在研。2014.01-2016.12    

8、江苏省临床医学科技专项--重点病种的规范化诊疗研究:难治性不孕症患者辅助生育技术规范化治疗方案研究,400万,在研。(BL20140032014.07-2017.06 

9、江苏省自然科学基金项目:输卵管积水增加miR-145调控子宫内膜间质细胞蜕膜化的分子机制研究,10万,在研。(NO.BK20141087)

 

 

                                    获奖情况

江苏省科技进步奖三等奖2项,江苏省新技术引进一等奖1项、二等奖2项,获得市级科技进步奖一等奖和三等奖各1项,南京市新技术引进特等奖1项。