徐 标

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:2

 

士研究生导师简介

姓名

徐标

研究方向

心血管内科

 

专业:

内科学

联系方式

13505193257

学术兼职:

国际心脏研究协会、美国心脏病学会会员

中华心血管学会动脉粥样硬化与冠心病分会委员

江苏省心血管学会副主任委员

南京市心血管病学会主任委员

江苏省中西医结合学会心血管分会副主任委员

海峡两岸医药卫生交流协会心血管专业委员会常委

Circulation Circulation Research, FASEB, Cardiovascular Diabetology,    International J Cardiology10多本SCI杂志的特约审稿人

《中华高血压杂志》、《中国动脉硬化杂志》、《南京医科大学学报》、《江苏医药》等10种杂志编委

个人简介

1. 工作简历

1981.09-1985.07  江苏省泰县人民医院、苏陈医院任住院医师

1989.09-1996.06  南京铁道医学院附院任主治医师

1996.07-2000.07  东南大学附属中大医院任心内科副主任医师

2000.07-2001.12  东南大学附属中大医院任主任医师、大内科主任、心内科主任

2002.01-2003.02  南通瑞慈医院主任医师、业务院长、心脏中心主任

扬州大学第四临床医学院常务副院长

2003-至今        南京大学附属鼓楼医院心脏科主任医师、心内科主任

 

2. 科研情况简介

近期研究领域:心肌梗死后心肌修复治疗和糖尿病下血管损伤的机制方面。

 

代表性论文

近五年发表SCI论文19篇,单篇最高影响因子 14.816.

1.Zhang XL, Li R, Wu H, Chen QH, Li GN, Xie J, Xu B. Head-to-head comparison of everolimus-eluting stents versus zotarolimus-eluting stents in patients undergoing percutaneous coronary intervention: a meta-analysis. Int J Cardiol. 2014 Mar 1;172(1):e203-6.

2.J. Xie, J. Wang, R. Li, Q. Dai, Y. Yong, B. Zong, Y. Xu, E. Li, A. Ferro, and B. Xu, 'Syndecan-4 over-Expression Preserves Cardiac Function in a Rat Model of Myocardial Infarction', J Mol Cell Cardiol (2012).

3.Ding L, Dong L, Chen X, Zhang L, Xu X, Ferro A, Xu B. Increased Expression of Integrin-Linked Kinase Attenuates Left Ventricular Remodeling and Improves Cardiac Function After Myocardial Infarction. Circulation. 2009;120:764-773.

4.Zhang J, Ding L, Zhao Y, Sun W, Chen B, Lin H, Wang X, Zhang L, Xu B, Dai J. Collagen-Targeting Vascular Endothelial Growth Factor improves Cardiac Performance After Myocardial Infarction. Circulation. 2009;119:1776-1784.

5.Zhang XL, Xie J, Li GN, Chen QH, Xu B. Head-to-head comparison of sirolimus-eluting stents versus paclitaxel-eluting stents in patients undergoing percutaneous coronary intervention: a meta-analysis of 76 studies. PLoS One. 2014 May 20;9(5):e97934. doi: 10.1371/journal.pone.0097934.

6.Jian Bai, Na Zhang Ying Hua, Bingjian Wang, Lin Ling, Albert Ferro, Biao XuMetformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts. 2013PLoS ONE 8(9): e72120. doi:10.1371/journal.pone.0072120

7.Lin Ling,Jian Bai,Rong Gu,Chunying Jiang,Ran Li,Lina Kang,Albert Ferro,and Biao Xu.3Sca-1+ Cardiac Progenitor Cell Therapy With Cells Overexpressing Integrin-Linked Kinase Improves Cardiac Function After Myocardial Infarction. Transplantation,Volume 95, Number 10, May 27, 2013 DOI: 10.1097/TP.0b013e31828a9423

8.Qing Mao,Cheng-Xi Lin, Xiu-Lin Liang, Jian-Shu Gao and Biao Xu.Mesenchymal stem cells overexpressing integrin-linked kinase attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions. Molecular medicine reports 7:1617-1623,  2013.

9.Jiangwei Ma, Zengyong Qiao, Biao Xu.Expression of sPLA2-V, estrogen and its target protein in myocardium tissue. International Journal of Biological Macromolecules 58 (2013) 176178.

10.Ruotian Li, Guijun Yan, Qiaoling Li, Haixiang Sun, Yali Hu, Jianxin Sun,Biao Xu.miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. PLoS ONE 7(9): e44907. doi:10.1371/journal.pone.0044907

11.R. Li, G. Yan, Q. Li, H. Sun, Y. Hu, J. Sun, and B. Xu, 'Microrna-145 Protects Cardiomyocytes against Hydrogen Peroxide (H(2)O(2))-Induced Apoptosis through Targeting the Mitochondria Apoptotic Pathway', PLoS One, 7 (2012), e44907.

12.R. Gu, J. Bai, L. Ling, L. Ding, N. Zhang, J. Ye, A. Ferro, and B. Xu, 'Increased Expression of Integrin-Linked Kinase Improves Cardiac Function and Decreases Mortality in Dilated Cardiomyopathy Model of Rats', PLoS One, 7 (2012), e31279.

13.R. Gu, D. Zheng, J. Bai, J. Xie, Q. Dai, and B. Xu, 'Altered Melusin Pathways Involved in Cardiac Remodeling Following Acute Myocardial Infarction', Cardiovasc Pathol, 21 (2012), 105-11.

14.L. Ling, Y. Shen, K. Wang, C. Jiang, C. Fang, A. Ferro, L. Kang, and B. Xu, 'Worse Clinical Outcomes in Acute Myocardial Infarction Patients with Type 2 Diabetes Mellitus: Relevance to Impaired Endothelial Progenitor Cells Mobilization', PLoS One, 7 (2012), e50739.

15. Gu R, Bai J, Ling L, Ding L, Zhang N, Ye JX, Ferro A, Xu B. Increased expression of integrin-linked kinase improves cardiac function and decreases mortality in dilated cardiomyopathy model of rats. PLoS ONE, 7(2): e31279. doi:10.1371/journal. pone. 0031279

16.Xie J, Xu B. The impairment of ILK related angiogenesis involves in cardiac maladaptation after infarction. PLoS One. Accepted.

17.Gu R, Lu W, Xie J, Bai J, Xu B. Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulation. PLoS One. 2011 Jan 31;6(1):e14633.

18.Kang LN, Chen Q, Wang L, Gao L, Meng K, Chen JH, Ferro A, Xu B. Decreased Mobilization of Endothelial Progenitor Cells Contributes to Impaired Neovascularization in Diabetes. Clin Exp Pharmacol Physiol. 2009 Jun 16.

19.Chen Q, Dong L, Wang L, Kang L, Xu B. Advanced glycation end products impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2. Biochem Biophys Res Commun. 2009 Apr 3.

 

承担课题

主要在研课题:

心肌高表达ILK对心力衰竭心功能的影响及其机制研究,国家自然科学基金面上项目 ,2010-2014年,课题编号81070195

高表达ILK治疗终末期心脏病江苏省卫生厅医学领军人才和领军团队2011-2015年,课题编号LJ201153

Cdx2+胎盘干细胞移植治疗急性心肌梗塞的实验研究,国家自然科学基金面上项目 ,2013-2017年,课题编号81270281

急性心肌梗死的规范化诊治的流程和新技术的建立及应用,江苏省临床医学科技专项2013-2017年,课题编号BL2012014

Pak3在心肌肥大中的作用和机制研究 ,国家自然科学基金面上项目,2014-2018年,课题编号81470371

                                    获奖情况

1. 糖尿病血管功能障碍的基础及临床研究

2013年,江苏医学奖一等奖,排名第一)

2.糖尿病血管功能障碍的基础及临床研究

2013年,江苏省科技进步奖三等奖,排名第一)

3.糖尿病血管功能障碍的基础及临床研究

2013年,南京市科技进步奖二等奖,排名第一)

4.促进EPC动员治疗心肌梗死的临床新技术应用

2014年,江苏省医学新技术引进奖,排名第一)