管晓翔

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:5

 

士研究生导师简介

姓名

管晓翔

研究方向

1.乳腺癌基础与临床

2.生物大分子结构与功能

 

专业:

肿瘤学

联系方式

电话025-80860053

Email:xguan@nju.edu.cn

学术兼职:

美国临床肿瘤学会(ASCO)会员

中国抗癌协会临床肿瘤学协作专业委员会(CSCO)青年委员

江苏省中西医结合学会化疗专业委员会常务委员

南京军区肿瘤专业委员会委员。

担任美国《Receptor & Clinical Investigation》杂志副主编

《Medicine》Academic Reviewer,担任《Biomedical Reports》编委

 

个人简介

1. 工作简历

1991.9-1996.7    南京医科大学临床医学专业      学士学位

1998.9-2003.7    南京医科大学病理生理学专业    硕士/博士学位

2003.9-2005.7    南京军区南京总医院            博士后

2008.2-2009.5    美国MD Anderson 肿瘤医院     访问助理教授

2012.2-2013.2    美国MD Anderson 肿瘤医院     访问教授

2012.12-至今     南京军区南京总医院            医师

2010.04-至今     南方医科大学                  博士生导师

2013.08-至今     南京大学                      博士生导师

 

2. 科研情况简介

作为第一负责人主持国家自然科学基金5项,主持江苏省重点病种(乳腺癌)规范化诊疗研究项目(200万),中国博士后基金和江苏省自然科学基金各1项,获得各项科研经费近500万元,主要集中于乳腺癌临床相关研究。国内外发表肿瘤相关研究性论文100余篇,其中国外SCI论文50余篇。相关工作发表在Clin Cancer Res, Oncotarget, Carcinogenesis, FASEB J, Cell Cycle, Breast Cancer Res等杂志上。

3.研究兴趣

近年的研究工作主要集中乳腺癌基础和临床相关研究,一直致力于细胞周期调控相关基因表达的研究,着重对乳腺疗效预测因子和关键性靶分子进行筛选和鉴定。

代表性论文[5年通讯作者和第一作者]

1.Lai J, Nie W, Zhang W, Wang Y, Xie R, Wang Y, Gu J, Xu J, Song W, Yang F, Huang G, Cao P, Guan X*.Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast cancer. Oncotarget. 2014 Jul 17.

2.Wang Y, He Y, Qin Z, Jiang Y, Jin G, Ma H, Dai J, Chen J, Hu Z, Guan X*, Shen H. Evaluation of functional genetic variants at 6q25.1 and risk of breast cancer in a Chinese population. Breast Cancer Res. 2014 Aug 14;16(4):422.

3.Lai J, Yang F, Zhang W, Wang Y, Xu J, Song W, Huang G, Gu J*, Guan X*.TAp73 and ΔNp73 Have Opposing Roles in 5-aza-2'-Deoxycytidine-Induced Apoptosis in Breast Cancer Cells.Mol Cells. 2014 Aug 18. doi: 0.14348/molcells.2014.0154

4.Tang L, Wang Y, Strom A, Gustafsson J.A* and Guan X*. Lapatinib induces p27(Kip1)-dependent G(1) arrest through both transcriptional and post-translational mechanisms. Cell Cycle. 2013 Aug 15;12(16):2665-74.

5.Yang F, Chen F, Gu J, Zhang W, Luo J and Guan X*. Genetic variant rs1058240 at the microRNA-binding site in the GATA3 gene may regulate its mRNA expression. Biomed Rep. 2014 May;2(3):404-407.

6.Huang X, Sun Q, Fu H, Zhou X, Guan X* and Wang J*. Both c-Myc and Ki-67 expression are predictive markers in patients with Extranodal NK/T-cell lymphoma, nasal type: A retrospective study in China. Pathol Res Pract. 2014 Jun;210(6):351-6.

7.Wang Z, Wang M, Yang F, Nie W, Chen F, Xu J and Guan X*. Multitargetedantiangiogenic tyrosine kinase inhibitors combined to chemotherapy in metastatic breast cancer: a systematic review and meta-analysis. Eur J ClinPharmacol. 2014 May;70(5):531-8.

8.He Y, Gong J, Wang Y, Qin Z, Jiang Y, Ma H, Jin G, Chen J, Hu Z, Guan X* and Shen H*. Potentially functional polymorphisms in aminoacyl-tRNAsynthetases genes are associated with breast cancer risk in a Chinese population. MolCarcinog.2014 Feb 9.

9.Guan X*, Liu Z, Wang L, Johnson D.G and Wei Q*. Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif. BiochemBiophys Res Commun. 2014 Jan 24;443(4):1239-44.

10.Wang Z, Zhang Q, Chen F, Wang Y, Nie W, Yang B and Guan X*. TCF7L2 rs12255372 (G>T) polymorphism contributes to breast carcinogenesis: evidence from a meta-analysis. Crit Rev Eukaryot Gene Expr. 2013;23(4):309-16.

11.Wang Z, Gu J, Nie W, Xu J, Huang G and Guan X*. Quantitative assessment of the association between three polymorphisms in FAS and FASL gene and breast cancer risk.Tumour Biol. 2014 Apr;35(4):3035-9.

12.Guan X, Liu H, Ju J, Li Y, Li P, Wang L.E, Brewster A.M, Buchholz T.A, Arun B.K, Wei Q and Liu Z. Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-hispanic white women aged </=55 years. MolCarcinog.2013 Oct 26.

13.Wang Z, Xu J, Nie W, Huang G, Tang J and Guan X*. Risk of hypertension with regorafenib in cancer patients: a systematic review and meta-analysis. Eur J ClinPharmacol. 2014 Feb;70(2):225-31.

14.Qin Z, Wang Y, Cao S, He Y, Ma H, Jin G, Hu Z, Guan X* and Shen H*. Genetic variants at 12p11 and 12q24 are associated with breast cancer risk in a Chinese population. PLoS One. 2013 Jun 12;8(6):e66519.

15.Guan X, Wang L.E, Liu Z, Sturgis E.M and Wei Q. Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites. J Cell Mol Med. 2013 Jul;17(7):873-8.

16.Tang L, Zhao Y, Nie W, Wang Z and Guan X*. 3' untranslated region 1630 C>T polymorphism of prohibitin increases risk of breast cancer. Onco Targets Ther. 2013 Mar 9;6:177-82.

17.Wang Z, Lai J, Wang Y, Nie W and Guan X*.The Hsa-miR-27a rs895819 (A>G) polymorphism and cancer susceptibility. Gene. 2013 May 25;521(1):87-90.

18.Wang X, Zhao Y, Wang Y, Wang Z and Guan X*. Association between a functional variant at PTGS2 gene 3'UTR and its mRNA expression in lymphoblastoid cell lines. Cell Biol Int. 2013 May;37(5):516-9.

19.Guan X, Niu J, Liu Z, Wang L.E, Amos C.I, Lee J.E, Gershenwald J.E, Grimm E.A and Wei Q. Variants in melanocortin 1 receptor gene contribute to risk of melanoma--a direct sequencing analysis in a Texas population. Pigment Cell Melanoma Res. 2013 May;26(3):422-5.

20.Guan X, Liu Z, Liu H, Yu H, Wang L.E, Sturgis E.M, Li G and Wei Q. A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer. FASEB J. 2013 Apr;27(4):1404-12.

21.Zhao Y, Tang L, Nie W, Wang Z and Guan X*. Functional variants at the miRNA binding sites of the E2F1 gene and its mRNA expression. Oncol Lett. 2013 Jan;5(1):398-402.

22.Guan X, Liu Z, Wang L, Wang L.E, Sturgis E.M and Wei Q. Functional repeats (TGYCC)n in the p53-inducible gene 3 (PIG3) promoter and susceptibility to squamous cell carcinoma of the head and neck. Carcinogenesis. 2013 Apr;34(4):812-7.

23.Guan X, Sturgis E.M, Song X, Liu Z, El-Naggar A.K, Wei Q and Li G. Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx. Cancer Lett. 2013 Apr 28;330(2):233-40.

24.Nie W, Jin L, Wang Y, Wang Z and Guan X*. The bioinformatics analysis of miRNAs signatures differentially expressed in HER2(+) versus HER2(-) breast cancers. Cancer BiotherRadiopharm. 2013 Feb;28(1):71-6.

25.Wang L, Tang L, Xie R, Nie W, Chen L and Guan X*. p16 promoter hypermethylation is associated with increased breast cancer risk. Mol Med Rep. 2012 Oct;6(4):904-8.

26.Wei F, Xu J, Tang L, Shao J, Wang Y, Chen L and Guan X*. p27(Kip1) V109G polymorphism and cancer risk: a systematic review and meta-analysis. Cancer BiotherRadiopharm. 2012 Dec;27(10):665-71.

27.Nie W, Tang L, Zhang H, Shao J, Wang Y, Chen L, Li D and Guan X*. Structural analysis of the EGFR TK domain and potential implications for EGFR targeted therapy. Int J Oncol. 2012 Jun;40(6):1763-9.

28.Guan X, Liao Z, Ma H, Qian J, Liu Z, Yuan X, Gomez D, Komaki R, Wang L.E and Wei Q. TNFRSF1B +676 T>G polymorphism predicts survival of non-small cell lung cancer patients treated with chemoradiotherapy. BMC Cancer. 2011 Oct 14;11:447.

29.Chen W, Wei F, Xu J, Wang Y, Chen L, Wang J and Guan X*. Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line. Int J Mol Med. 2011 Dec;28(6):985-91.

30.Guan X*, Du L, Chen L, Chen Y and Wang J. Variation of gene expression profile linked to p27 (Kip1) Ser(10) phosphorylation status in MCF-7 cell line. Biomed Pharmacother. 2011 Dec;65(8):537-41.

31.Guan X, Yin M, Wei Q, Zhao H, Liu Z, Wang L.E, Yuan X, O'Reilly M.S, Komaki R and Liao Z. Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy. BMC Cancer. 2010 Aug 16;10:431.

32.Guan X, Sturgis E.M, Lei D, Liu Z, Dahlstrom K.R, Wei Q and Li G. Association of TGF-beta1 genetic variants with HPV16-positive oropharyngeal cancer. Clin Cancer Res. 2010 Mar 1;16(5):1416-22.

33.Guan X, Zhao H, Niu J, Tang D, Ajani J.A and Wei Q. The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. BMC Gastroenterol.2009 Oct 16;9:77.

34.Guan X, Zhao H, Niu J, Tan D, Ajani J.A and Wei Q. Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. J ExpClin Cancer Res. 2009 Jun 30;28:94.

35.Guan X, Wang Y, Xie R, Chen L, Bai J, Lu J and Kuo M.T. p27(Kip1) as a prognostic factor in breast cancer: a systematic review and meta-analysis. J Cell Mol Med. 2010 Apr;14(4):944-53.

承担科研项目[项目负责人]

 

1.国家自然科学基金面上项目:prohibitin与PIG3基因启动子区(TGYCC)n序列结合并调控其转录的分子机制【No.81470357】80万 2015.1-2018.12

2.国家自然科学基金面上项目:miRNA-150靶向p27基因转录后调控的分子机制【No.81272252】83万 2013.1-2016.12

3.江苏省临床医学科技专项:三阴性乳腺癌规范化诊疗研究[No.BL20140773] 200万 2014.7-2017.7

此外有三项国家自然科学基金【No.30470663,30870962,81141094】已经结题。

 

 

获奖情况

 

2006年获美国癌症协会(ACS)研究学者奖

2008年获欧洲乳腺癌专家学会(EUSOMA)研究学者奖各一项,

2010年获国家教育部自然科学二等奖(排名第一)

2011年军队医疗成果二等奖奖(排名第三)

2010年获江苏省医学重点人才

2010年获江苏省 “333高层次人才

2010年获江苏省十大青年科技之星荣誉称号。