施 毅

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:1

 

博士研究生导师简介

姓名

施毅

研究方向

1.    肺部感染

2.    急性肺损伤

3.    肺癌

 

  专业:

内科学

联系方式

Email:shiyi56@126.com

学术兼职:

内科教研室主任;美国胸科医师学会资深会员;中国医师协会呼吸医师分会常委兼基层工作委员会副主任委员;江苏省医师协会呼吸医师分会会长;江苏省医学会呼吸病学分会主任委员兼感染学组组长;解放军呼吸专业委员会常委;南京医学会结核和呼吸专科分会主任委员;南京军区内科领域副主任委员;《医学研究生学报》副主编;《中国呼吸与危重监护杂志》等杂志编委。

 

个人简介

1. 工作简历

197610月参加工作,1983年毕业于重庆第三军医大学军医系,获学士学位;1988年毕业于北京解放军军医进修学院(解放军总医院),获硕士学位;2002年毕业于上海第二军医大学,获博士学位。1983-1985年在第三军医大学附属西南医院呼吸科工作,1988-1989年在北京解放军总医院呼吸科工作。1990年起在南京军区南京总医院呼吸科工作至今。目前为呼吸病研究所所长,主任医师,教授,南京大学医学院、第二军医大学和南方医科大学博士生导师,南京总医院博士后工作站联系导师。

2. 科研情况简介

先后主持参加国家自然科学基金面上项目2项,军区重点课题1项和一般项目3项,江苏省基金3项,其它课题6项。相关工作发表在Eur J Clin PharmacolCellular ImmunologyEuropean journal of clinical microbiology & infectious disease等杂志上。

3. 研究兴趣

肺部感染:①抗菌药物的合理应用。②细菌和真菌的耐药机制。③侵袭性肺部真菌感染发病机制。④呼吸道病毒感染发病机制。

急性肺损伤:①新的机械通气模式(如肺开放技术、保护性肺通气等)的作用机制和临床应用研究。②急性肺损伤的发病机制研究。③重症肺部感染与急性肺损伤。

肺癌:①肺癌发病机制。②肺癌的早期诊断。③肺癌治疗新药的临床研究。

 

代表性论文

专著及SCI论文

1.Prevalence and risk of viral infection in patients with acute exacerbation of chronic obstructive pulmonary disease:a meta-analysi.sMol Biol Rep (2014) 41:4743–4751(通讯作者)

2.Vitamin D Deficiency Causes Defective Resistance to Aspergillus fumigatus in Mice via Aggravated and Sustained Inflammation.PLOS ONE; 2014;6( 9):1-12(通讯作者)

3.Tristetraprolin is involved in the glucocorticoid-mediated interleukin 8 repression. International Immunopharmacology 22 (2014) 480–485(通讯作者)

4.Efficacy of combination therapy of triazole and echinocandin in treatment of invasive aspergillosis: a systematic review of animal and human studies. Journal of Thoracic Disease. 2014;6(2):99-108.(通讯作者)

5.Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species. Mycopathologia. 2014,177:11-18(通讯作者)

6.Chemotherapy plus Vandetanib or Chemotherapy Alone in Advanced Non-small Cell Lung Cancer: A Meta-analysis of Four Randomised Controlled Trials Clinical Oncology  (2012) e1-e9(通讯作者)

7.Overexpression of periostin predicts poor prognosis in non-small cell lung cancer. ONCOLOGY LETTERS. 2013, 6: 1595-1603.(通讯作者)

8.Dectin-2 is predominately macrophage restricted and exhibits conspicuous expression during Aspergillus fumigatus invasion in human lung. Cellular Immunology. 2013,  284(1-2):60–67(通讯作者)

9.Activation of NF-κB and respiratory burst following Aspergillus fumigatus stimulation of macrophages. Immunobiology. Available online 4 July 2013.In Press, Corrected Proof — Note to users(通讯作者)

10.Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor-induced interleukin-6 expression via human antigen R. Chin Med J. 2013,126 (22):1-5(通讯作者)

11.Effect of noninvasive, positive pressure ventilation on patients with severe, stable chronic obstructive pulmonary disease: a meta-analysis. Chin Med J (Engl). 2013, 126(1):140-146. (通讯作者)

12.Diagnosis of airway-invasive pulmonary aspergillosis by tree-in-bud sign in an immunocompetent patient:Case report and literature review;Journal de Mycologie Médicale (2013) 23, 64—69(通讯作者)

13.Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells. European journal of clinical microbiology & infectious diseases .2012,31(10):2755-64(通讯作者)

14.Chemotherapy plus multitargeted antiangiogenic tyrosine kinase inhibitors or chemotherapy alone in advanced NSCLC: a meta-analysis of randomized controlled trials. Eur J Clin Pharmacol.. 2013 10.1007/s00228-012-1333-3.(通讯作者)

15.MK2 post-transcriptionally regulates TNF-α-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells. AJP Lung. 2012,302,793-799

16.HuR post-transcriptionally regulates TNF-induced IL-6 expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin. Respiratory Physiology Neurobiology. 2012:154– 161

17.E-cadherin mediates adhesion and endocytosis of Aspergillus fumigatus blastospores in human epithelial cells. Chinese Medical Journal. 2012 ;125(4):617-621(通讯作者)

18.Inhibition of pre-B cell colony-enhancing factor attenuates inflammation and apoptosis induced by pandemic H1N1 2009 in lung endothelium. Respiratory Physiology & Neurobiology. 2011,178:235-241.(通讯作者)

19.Induction of immune tolerance in asthmatic mice by vaccination with DNA encoding an allergen- cytotoxic T lymphocyte-associated antigen 4 combination. Clin Vaccine Immunol ,May 2011;807-814(通讯作者)

20.A soluble thymic stromal lymphopoietin (TSLP) antagonist,TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cell;Clinical and Experimental Immunology ;2011(通讯作者)

21.Evaluation of PCR on Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Aspergillosis: A Bivariate Metaanalysis and Systematic Review.Plos One, December 2011;6(12):e28467 (通讯作者)

22.Antithrombin-Ⅲ without concomitant heparin improves endotoxin induced acute lung injury rats by inhibiting the activiation of mitogen-activated protein kinase;J Chin Med; 2009, 122(20):2466-2471(通讯作者)

23.Expression of periostin in the serum of NSCLC and its function on proliferation and migration of human lung adenocarcinoma cell line (A549) in vitro. Mol Biol Rep; 2009, 18(通讯作者)

24.High mobility group box 1 as a mediator of endotoxin administration after hemorrhagic shock-primed lung injury. Brazilian Journal of Medical and Biological Research (2009) 42: 804-811(通讯作者)

25.Comparison of three different PCR-based methods to predict the penicillin nonsusceptible Streptococcus pneumoniae isolates from China. Letters in Applied Microbiclogy 2008,48:105-111(通讯作者)

26.Effects of different levels of end-expiratory positive pressure on lung recruitment and protection in patients with acute respiratory distress syndrome;Chin Med J 2008;121(22):2218-2223(通讯作者)

27.2009,《感染性疾病-基于临床病例的诊治析评》,人民卫生出版社,副主编

承担科研项目

1.2015.01-2018.12,肺内皮细胞SLPR1受体在流感病毒所致ARDS中的作用,国家自然科学基金面上项目,75万元,项目批准号:81470206 ,第一负责人

2.2013-2015,PU.1/Dectin-1在气道上皮细胞应对烟曲霉感染的作用和机制研究,国家自然科学基金面上项目,70万元,项目批准号:81270064 ,第一负责人

3.2010-2012;MK2信号通路在急性肺损伤中的调控作用,南京军区医药卫生重点课题。30万元,09Z028;第一负责人

4.2010-2011,MK2信号通路在急性肺损伤中的调控作用,江苏省自然科学基金。8万元,BK2009318,第一负责人

5.2008-2010,靶向NF-kBp65亚基穿膜拮抗肽治疗急性肺损伤的实验研究,南京总医院重点课题。10万元(Z2008014),第一负责人

6.2007-2010,RNA干扰TSLPRr基因靶向修饰未成熟树突状细胞诱导哮喘免疫耐受的研究,全军医药卫生科研课题,5万元,第一负责人

7.2011-2013,E-钙粘蛋白:烟曲霉孢子侵袭肺泡上皮细胞的重要受体?国家自然基金青年基金,20万元,项目批准号:81000003,第二负责人

8.2011-2013,TTP和HuR在急性肺损伤重要炎症因子表达中的作用,江苏省自然基金,8万元,BK2011657,第二负责人

获奖情况

1.2013年8月,“侵袭性肺真菌病的临床诊治和实验研究”,获军队医疗成果二等奖,第一贡献者

2.2008年10月,“肺炎衣原体呼吸道感染临床与发病机制的研究”,获军队医疗成果二等奖,第一贡献者

3.2009年8月, “创伤性急性肺损伤发病的分子机制”,获军队科技进步二等奖,第二贡献者

4.2011年8月,“肺癌多学科综合诊治的临床研究”,获军队医疗成果二等奖,第二贡献者