宋 勇

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:2

 

博士研究生导师简介

姓名

研究方向

1.肺癌

2.急性肺损伤

 

专业:

内科学

联系方式

电话025-80860148

Email:yong_song6310@yahoo.com

学术兼职:

全军呼吸内科专业委员会副主任委员

南京军区呼吸内科委员会主任委员

江苏省医学会呼吸分会副主任委员

中国抗癌协会肺癌专业委员会委员

《Translational lung cancer research》主编,SCI杂志《Journal of Thoracic Disease》编委

JTO中文版编委

《医学研究生学报》编委

 

个人简介

1. 工作简历

1984.091987.09    安徽淮南第一医院呼吸科            住院医师

1992.121999.12    南京军区南京总医院呼吸内科        主治医师

1999.122000.02    南京军区南京总医院呼吸内科        副主任医师

2002.072014.04    南京军区南京总医院呼吸内科        副主任,主任医师

2014.04~至今       南京军区南京总医院呼吸内科        主任,主任医师

2. 科研情况简介

主持和承担国家自然科学基金、国家新药基金、江苏省重点科研基金等多项研究课题。以第一作者和通讯作者发表研究论著120余篇,SCI论文72篇,主编主译专著6本。以第一完成人获省部级和军队二等奖4项。被遴选为江苏省“333高层次培养人才”、南京军区“334”领军人才培养对象;荣立三等功2次,获江苏省医学重点人才、江苏省有突出贡献的中青年专家、南京军区科技英才、南京军区优秀科技人才津贴等多项称号和奖励。

3. 研究兴趣

近年的研究工作主要集中:线粒体DNA在急性肺损伤发表机制中的作用和机制。肺癌:1、围绕恶性胸腔积液的发病机制和临床研究。2、肺癌转移的发病机制和临床研究。3、长链非编码RNA在肺癌发病机制的作用和意义。4、肺癌患者数据库和标本库的回顾性和前瞻性研究。

代表性论文

1.Yan Li, Li-Xin Qiu, Xiao-Kun Shen, Xiao-Ping Qian, Yong Song .A meta-analysis of TP53 codon 72 polymorphism and lung cancer risk:Evidence from 15,857 subjects. Lung Cancer2009.(通讯作者)

2.Tangfeng Lv, PhD, Xiaokun Shen, MD, Yi Shi, MD, and Yong Song, MD.TLR4 is Essential in Acute Lung Injury Induced by Unresuscitated Hemorrhagic Shock. The Journal of TRAUMA_ Injury, Infection, and Critical Care 2009:124-131. (通讯作者)

3.Ping Zhan, Jing Wang, Qin Wang, Xin-qing Lin, Yan Li and Yong Song.

Prognostic value of vascular endothelial growth factor expression in patients with lung cancer: a meta-analysis. J Thorac Oncol 2009. (通讯作者)

4.Xiaokun Shen, Lingzhi Hong, Huiming Sun, Minke Shi, Yong Song. The expression of high-mobility group protein box1 correlates  with the progression of non-small cell lung cancer. ONCOLOGY REPORTS 22:535-539,2009.(通讯作者)

5.Yong song ,M.D ,ph.D,David A.Fullerton,M.D, David  Mauchley,M.D,Xin Su ,M.D.Microfilaments Facilitate TLR4-Mediated ICAM-1 Expression in Human Aortic Valve Interstitial Cells .Journal of Surgical Research,1-7,2009.(第一作者)

6.Ping Zhan, Jing Wang, Yu Zhang, Li-Xin Qiu, Su-feng Zhao, Qian Qian,Shu-Zhen Wei, Li-Ke Yua, Yong Song.CYP2E1 Rsa I/Pst I polymorphism is associated with lung cancer risk among Asians. Lung Cancer. 2009 Sep 29. (通讯作者)

7.Qian Qian, Qian Wang, Ping Zhan , Ling Peng , Shu-Zhen Wei , Yi Shi , Yong Song.The Role of Matrix Metalloproteinase 2 on the Survival of Patients with Non Small Cell Lung Cancer: a systematic review with meta-analysis。Cancer Investigation,2010;28(6):661-9 (通讯作者 )

8.Ping Zhan,Qin Wang,Shu-Zhen Wei,Jing Wang,Qian Qian,Li-Ke Yu,Yong Song. ERCC2/XPD Lys751Gln and Asp312Asn Gene Polymorphism and Lung Cancer Risk A Meta-Analysis Involving 22 Case-Control Studies.Journal of Thoracic Oncology ,2010; 5(9):1337-45 .( (通讯作者)

9.PingZhan,JingWang,Shu-ZhenWei,QianQian,Li-XinQiu,Li-KeYu,YongSong.TNF-308 gene polymorphism is associated with COPD riskAmong Asians:meta-analysis of data for 6,118 subjects. Mol Biol Rep,2010; 38(1):219-27.(通讯作者)

10.Qian Q, Zhan P, Yu L, Shi Y, Cheng J, Wei S, Wang Q, Song Y.Baseline levels and decrease in serum soluble intercellular adhesion molecule-1 during chemotherapy predict objective response and survival in patients who have advanced non-small-cell lung cancer.Clin Lung Cancer. 2011 Mar;12(2):131-7. (通讯作者)

11.Yong song, M.D, ph.D, David A.Fullerton, M.D, David  Mauchley,M.D, Xin Su, M.D .Microfilaments facilitate TLR4-mediated ICAM-1 expression in human aortic valve interstitial cells. J Surg Res. 2011 Mar;166(1):52-8. (第一作者 )

12.Shu-Zhen Wei, Ping Zhan, Mei-Qi Shi, Yi Shi, Qian Qian, Li-ke Yu and Yong Song..Predictive value of ERCC1 expression in patients with non-small cell lung cancer patients receiving platinum-based chemotherapy: a system review and meta-analysis. Med Oncol 2011; 28(1):315-21 (通讯作者 )

13.Lv YL, Yuan DM, Wang K, Miao XH, Qian Q, Wei SZ, Zhu XX, Song Y.Diagnostic performance of integrated positron emission tomography/computed tomography for mediastinal lymph node staging in non-small cell lung cancer: a bivariate systematic review and meta-analysis.J Thorac Oncol. 2011 Aug;6(8):1350-8.  (通讯作者)

14.Ping Zhan , Li-jun Suo , Qian Qian , Xiao-kun Shen , Li-Xin Qiu , Li-ke Yu ,Yong Song.Chlamydia pneumoniae infection and lung cancer risk:A meta-analysis. EUROPEAN JOURNAL OF CANCER,2011:742-747(通讯作者)

15.Yan Li, Stephen J. Swensen, Leman G�nbey Karabekmez, Randolph S. Marks,Shawn M. Stoddard, Ruoxiang Jiang, Joel B. Worra, Fang Zhang, David E. Midthun,Mariza de Andrade, Yong Song, and Ping Yan..Effect of Emphysema on Lung Cancer Risk in Smokers: A Computed Tomography -Based Assessment. Cancer Prev Res 2011;4:43-50. (通讯作者)

16.Yuan DM, Lü YL, Yao YW, Liu HB, Wang Q, Xiao XW, Cao EH, Shi Y, Zhou XJ, Song Y.Diagnostic efficiency and complication rate of CT-guided lung biopsy: a single center experience of the procedures conducted over a 10-year period.Chin Med J (Engl). 2011 Oct;124(20):3227-31. (通讯作者)

17.Ma C, Wei S, Song Y.T790M and acquired resistance of EGFR TKI: a literature review of clinical reports.J Thorac Dis. 2011 Mar;3(1):10-8.  (通讯作者)

18.Yao Y, Yuan D, Liu H, Gu X, Song Y.Pretreatment neutrophil to lymphocyte ratio is associated with response to therapy and prognosis of advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy.Cancer Immunol Immunother. 2013 Mar;62(3):471-9. (通讯作者)

19.Luo L, Lv T, Wang Q, Zhang T, Gu X, Xu F, Song Y.Activated protein C induces endoplasmic reticulum stress and attenuates lipopolysaccharide-induced apoptosis mediated by glycogen synthase kinase-3β.Mediators Inflamm. 2012;2012:485279. (通讯作者)

20.Luo L, Zhang T, Liu H, Lv T, Yuan D, Yao Y, Lv Y, Song Y.MiR-101 and Mcl-1 in non-small-cell lung cancer: expression profile and clinical significance.Med Oncol. 2012 Sep;29(3):1681-6. (通讯作者)

21.Yuan DM, Wei SZ, Lü YL, Zhang Y, Miao XH, Zhan P, Yu LK, Shi Y, Song Y.Single-agent maintenance therapy in non-small cell lung cancer: a systematic review and meta-analysis. Chin Med J (Eng). 2012;125(17):3143-9 (通讯作者)

22.Dong-mei Yuan, Yan-ling Lv, Yan-wen Yao, Xiao-hui Miao, QianWang, Xin-wu Xiao, Jie Yin,Yi Shi, Mei-qi Shi, Xiu-wei Zhang& Yong Song.Efficacy and safety of Abraxane in treatment of progressive and recurrent non-small cell lung cancer patients: A retrospective clinical study. Thoracic Cancer;2012:341-347. (通讯作者)

23.Lv T, Yuan D, Miao X, Lv Y, Zhan P, Shen X, Song Y.Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer.PLoS One. 2012;7(4):e35065. (通讯作者)

24.Yong-Ying Xiao & Ping Zhan & Dong-Mei Yuan ,Hong-Bing Liu & Tang-Feng Lv & Yong Song & Yi Shi.Chemotherapy plus multitargeted antiangiogenic tyrosine  kinase inhibitors or chemotherapy alone in advanced  NSCLC: a meta-analysis of randomized controlled trials. Eur J Clin Pharmacol. 2012 (通讯作者)

25.Xiao YY, Zhan P, Yuan DM, Liu HB, Lv TF, Shi Y, Song Y.Chemotherapy plus Vandetanib or chemotherapy alone in advanced non-small cell lung cancer: a meta-analysis of four randomised controlled trials.Clin Oncol (R Coll Radiol). 2013 Jan;25(1):e7-e15. (通讯作者)

26.Ma X, Yao Y, Yuan D, Liu H, Wang S, Zhou C, Song Y.Recombinant Human Endostatin Endostar Suppresses Angiogenesis and Lymphangiogenesis of Malignant Pleural Effusion in Mice. PLOS ONE. 2012; 7(12 ) (通讯作者)

27.Xingqun Ma, Yu Sun, Shouju Wang, Zhijian Yang, Yong Song.Establishment of A Malignant Pleural Effusion Mouse Model with Lewis Lung Carcinoma Cell Lines Expressing Enhanced Green Fluorescent Protein. Transl Lung Cancer Res.  2012;1(3):170-178 (通讯作者)

28.Lv YL, Yuan DM, Wang QB, Zhan P, Luo L, Lv TF, Liu HB, Li YF, Wen J, Song Y.Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.Med Oncol. 2012 Dec;29(4):2633-9.

29.Circulating soluble intercellular adhesion molecule-1 in lung cancer: A systematic review. Translational lung cancer research. 2012;1(1): 36-44 (通讯作者)

30.Prognostic value of the ratio of ground glass opacity on computed tomography in small lung adenocarcinoma: A meta-analysis. J Thorac Dis 2012(通讯作者)

31.H. B. LIU, X. L. GU, X. Q. MA, T. F. LV, Y. WU, Y. Y. XIAO, D. M. YUAN, Y. F. LI, Y. SONG. Preoperative platelet count in predicting lymph node metastasis and prognosis in patients with non-small cell lung cancer. Neoplasma .2013:60( 2), doi:10.4149 (通讯作者)

32.Liu HB, Wu Y, Lv TF, Yao YW, Xiao YY, Yuan DM, Song Y.Skin rash could predict the response to EGFR tyrosine kinase inhibitor and the prognosis for patients with non-small cell lung cancer: a systematic review and meta-analysis. (通讯作者)

33.Xuefei Shi, Ming Sun, Hongbing Liu, Yanwen Yao, Yong Song.Long non-coding RNAs: A new frontier in the study of human diseases. Cancer Letters 339 (2013) 159–166. (通讯作者)

34.Yao Y, Gu X, Zhu J, Yuan D, Song Y. Hormone Replacement Therapy in Females Can Decrease the Risk of Lung Cancer: A Meta-Analysis. PLOS  ONE,2013,8(8):e71236. (通讯作者)

35.Miao L, Wang Y, Xia H, Yao C, Cai H, Song Y.SPOCK1 is a novel transforming growth factor-β target gene that regulates lung cancer cell epithelial-mesenchymal transition.Biochem Biophys Res Commun. 2013 Nov 1;440(4):792-7. (通讯作者)

36、Miao L, Zhu S, Wang Y, Li Y, Ding J, Dai J, Cai H, Zhang D, Song Y.Discoidin domain receptor 1 is associated with poor prognosis of non-small cell lung cancer and promotes cell invasion via epithelial-to-mesenchymal transition.Med Oncol. 2013;30(3):626. (通讯作者)

37、Zhan P, Xie H, Xu C, Hao K, Hou Z, Song Y.Management strategy of solitary pulmonary nodules.J Thorac Dis. 2013 Dec;5(6):824-829. (通讯作者)

38、 Liu H, Wu Y, Wang Z, Yao Y, Chen F, Zhang H, Wang Y, Song Y. Pretreatment platelet-to-lymphocyte ratio (PLR) as a predictor of response to first-line platinum-based chemotherapy and prognosis for patients with non-small cell lung cancer.J Thorac Dis. 2013 Dec;5(6):783-9. (通讯作者)

39、Shi X, Sun M, Liu H, Yao Y, Kong R, Chen F, Song Y.A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer.Mol Carcinog. 2013 Dec 19(通讯作者)

40、Gu X, Yao Y, Wu G, Lv T, Luo L, Song Y.The plasma mitochondrial DNA is an independent predictor for post-traumatic systemic inflammatory response syndrome.PLoS One. 2013 Aug 20;8(8):e72834. (通讯作者)

41、Xuefei Shi, Ming Sun, Hongbing Liu, Yanwen Yao,1Rong Kong, Fangfang Chen and Yong Song. A Critical Role for the Long Non-Coding RNA GAS5 in Proliferation and Apoptosis in Non-Small-Cell Lung Cancer. MOLECULAR CARCINOGENESIS.2014(通讯作者)

42、Wu G, Zhao M, Gu X, Yao Y, Liu H, Song Y.The effect of P2X7 receptor 1513 polymorphism on susceptibility to tuberculosis: A meta-analysis.Infect Genet Evol. 2014 Jun;24C:82-91. (通讯作者)

43、He Zhang, Hong-bing Liu, Dong-mei Yuan, Zhao-feng Wang, Yun-fen Wang and Yong Song.Prognostic value of secreted phosphoprotein-1 in pleural effusion associated with non-small cell lung cancer. BMC Cancer 2014, 14:280(通讯作者)

44、Liu C, Shi X, Wang L, Wu Y, Jin F, Bai C, Song Y.SUZ12 is involved in progression of non-small cell lung cancer by promoting cell proliferation and metastasis.Tumour Biol. 2014 Mar 15. [Epub ahead of print] (通讯作者)

45、Zhang S, Zhan P, Song Y.Comment on Zhou et al. entitled "High plasma D-dimer level is associated with decreased survival in patients with lung cancer: a meta-analysis based on current evidence".Tumour Biol. 2014 Feb;35(2):917. (通讯作者)

46、        Cui-Qing Bai, Yan-Wen Yao, Chun-Hua Liu, He Zhang, Xiao-Bing Xu, Jun-Li

Zeng, Wen-Jun Liang, Wen Yang, Yong Song. Diagnostic and prognostic significance of lysophosphatidic acid in malignant pleural effusions. J Thorac Dis 2014;6(5):483-490(通讯作者)

47、        Hongbing Liu, Ying Wu, Zhaofeng Wang andYong Song.Response to first-line chemotherapy of docetaxel combined with platinum predicting the prognosis and subsequent treatment of patients with non-small cell lung cancer. Thoracic Cancer,Volume 5, Issue 4, pages 337–342, July 2014(通讯作者)

48、Yao Y ,Gu X, Liu H,Wu G,Yuan D,Yang X,Song Y.Metadherin regulates proliferation and metastasis via actin cytoskeletal remodelling in non-small cell lung cancer. British journal of cancer 2014 Jun; (通讯作者)

49、        Liu H, Gu X, Lv T, Wu Y, Xiao Y, Yuan D, Li Y, Song Y.The role of serum carcinoembryonic antigen in predicting responses to chemotherapy and survival in patients with non-small cell lung cancer. J Cancer Res Ther. 2014 Apr-Jun;10(2):239-43(通讯作者)

承担科研项目

1.肺癌规范化诊疗研究,江苏省重点病专项课题,400万元,编号:BL2013026,2013-2016

2.循环mtDNA-NLRP3 炎性体信号通路介导创伤性急性肺损伤发生的分子机制,国家自然基金,70万元,编号:81370172,2014-2017

3.SOX2调控TGFβR2的表达调节肺鳞癌转移的机制,军区面上项目,10万元,编号:12MA083,2013-2015

4.mtDNA始动创伤性急性肺损伤的新机制,国家自然基金面上项目,52万元,编号:81170064,2012-2014

5.miR-1297调控早期非小细胞肺癌转移的相关机制研究。江苏省自然基金,8万元,编号:BK2011658, 2012-2014

6.Akt1/Akt2表达失衡调控内毒素诱导急性肺损伤的新机制,军区面上项目,10万元,编号:10MA093,2011-2013

获奖情况

1.2011年,肺癌多学科综合诊治的临床研究,军队医疗成果二等奖,第一完成人;

2.2009年,创伤性急性肺损伤发病的分子机制,军队科技进步二等奖,第一完成人;

3.2005年,急性肺损伤分子发病机制的研究,教育部提名国家科技奖自然科学二等奖,第一完成人;

4.2003年,急性肺损伤分子发病机制和应用研究,江苏省科技进步二等奖,第一完成人。