汪芳裕

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:1184

博士研究生导师简介

姓名

汪芳裕

研究方向:

消化道早期癌内镜诊治;炎症性肠病的发病机制及肠道微生态相关研究;消化道肿瘤疾病分子标志物的探索

联系方式

13515100636


学术兼职:

中华医学会消化病学分会委员

江苏省医学会消化病学分会候任主任委员


个人简介


承担国家自然科学基金4项、总后勤部和南京军区卫生部医药卫生科研基金多项;参与“十一五”国家科技支撑计划重大项目等,基金总金额240万元。发表论著120余篇,其中SCI论文40余篇,总影响因子75.817分,主编及参编论著5部。担任《中华消化内镜杂志》、《医学研究生学报》、《解放军医药杂志》、GIEJGHWJG等多家中英文杂志编委及审稿专家。培养硕士博士研究生20余名。曾作为高级访问学者赴日学习交流。


代表性论文[5年通讯作者和第一作者]


 1.L. Ye, X.L. Sun, H.M. Wu, J. Wang, X. Ding, H. Shi, L.S. Lu, J. Wei, L. Li, F.Y. Wang.A simple system for differentiation of functional intestinal stem cell-like cells from bone marrow mesenchymal stem cells.Molecular Therapy-Nucleic Acids.Available online (IF=6.392)

 2.Hui-Min Wu, Juan Wei, Kai Wang , Ying Qi, Fang-Yu Wang.Mucus protectors: Promising therapeutic strategies for inflammatory bowel disease.Medical Hypotheses.2018(120),55-59 (IF=1.066)

 3.Lei Ye, Wei Chen, Bi-qin Chen, Xing Lan, Shao-dong Wang, Xiao-chen Wu, Wei Huang, Fang-yu Wang. Levels of Faecal Calprotectin and Magnetic Resonance Enterocolonography Correlate with Severity of Small Bowel Crohn’s Disease: A Retrospective Cohort Study. Scientific Reports. 2017 May 16;7(1):1970 (IF=5.2)

 4.Lei Ye, Yu-Ping Zhang, Na Yu, Ya-Xu Jia, Shu-Jun Wan, Fang-Yu Wang. Serum platelet factor 4 is a reliable activity parameter in adult patients with inflammatory bowel disease: a pilot study. Medicine (Baltimore). 2017;96(11):e6323. (IF=2.1)

 5.Lei Ye, Bi-qin Chen, Shao-dong Wang, Chen Wei, Xiao-chen Wu, Zhao Yang, Fang yu Wang. Fecal calprotectin is a strong predictive marker of relapse in Chinese patients with Crohn's disease: a two-year prospective study.Scandinavian Journal of Gastroenterology2017:1-7(IF=2.5)

 6.Chen B, Yang Z, Lu H, Wei C, Wang F, Liu C. Eosinophilic Gastroenteritis Presenting as Upper Gastrointestinal Hematoma and Ulcers After Endoscopic Biopsy: A Case Report and Literature Review. MEDICINE. 2017;96(37):e8075 .(IF1.803)

 7.Yu-Ping Zhang,Chang Liu,Lei Ye,Na Yu,Yuan-Ning Ye,Wen-Rong Sun,Lin Wu,Fang-Yu Wang. Early Prediction of Persistent Organ Failure by Serum Angiopoietin-2 in Patients with Acute Pancreatitis. Dig Dis Sci. 2016,61(12):3584-3591 (IF=2.5)  

 8.Wang Z,Lu H,Wu L,Yuan B, Liu J, Shi H, Wang F.Long-term outcomes of endoscopic multiband mucosectomy for early esophageal squamous cell neoplasia: a retrospective, single-center study.Gastrointestinal Endoscopy. 2016,84(6):893-899 (IF=6.217

 9.Chang Liu,Jie Dai,Heng Lu,Hui Shi,Youke Lu,Fangyu Wang. EGCG suppresses NF-kB activation induced by gastroesophageal reflux contents in human esophageal epithelial cells. Int J Clin Exp Pathol. 2016,9(5):5421-5428(IF=1.581)

 10.Lei Ye, Hui Shi, Min Wu, et al. Primarily isolated hepatic involvement of amyloidosis: a case report and overview. Medicine (Baltimore).2016;95(52):e5645. (IF=2.1)

 11.Shi Hui, Wang Fangyu.Protective effects of bilobalide against ethanol-induced gastric ulcer in vivo/vitro. Biomedicine & Pharmacotherapy .2017,85,592–600 (IF=3.457)  

 12.Wang Z, Yang X, Wu L, Shi H, Lu Y, Yuan B, Wang Y, Wang F. Blue rubber bleb nevus syndrome: treatment of lesions in the small intestine with repeated injection of lauromacrogol. Gastrointest Endosc. 2015,81(5):1274-1275.IF=6.217

 13.Wu XW, Wu L, Ji HZ, Wang FY. Relationship between cytomegalovirus infection and steroid-resistance in inflammatory bowel disease: a meta-analysis. Dig Dis Sci. 2015,60(11):3203-3208(IF=2.5)  

 14.Wu XW, Yang MF, Li N, Wang FY. Unfavorable outcome of antiviral therapy in cytomegalovirus-positive ulcerative colitis may be due to inappropriate study inclusion in meta-analysis. World J Gastroenterol. 2015,21(5):1689-1690(IF=2.787)

 15.Wu XW, Ji HZ, Yang MF, Wu L, Wang FY. Helicobacter pylori infection and inflammatory bowel disease in Asians: A meta-analysis. World J Gastroenterol. 2015, 21(15):4750-4756(IF=2.787)

 16.Bosi Yuan, Shuping Zhou, Youke Lu, Jiong Liu, Xinxin Jin,Haijun Wan,and Fangyu Wang. Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis. Gut Liver. 2015,23;9(6):734-740(IF=2)

 17.Chang Liu, Jiong Liu, Fangyu Wang.Intrahepatic splenosis mimicking liver cancer: report of a case and review of literatureInt J Clin Exp Pathol.2015,8(1):1031-1035(IF=1.581)

 18.Zhenkai WangHui ShiShaodong WangJiong LiuWeiming ZhuMiaofang YangChang LiuHeng LuFangyu Wang. Confusing untypical intestinal Behcet’s disease: Skip ulcers with severe lower gastrointestinal hemorrhage. World Journal of Gastrointestinal Endoscopy. 2014,6(1):27-31(IF=2.5)

 19.袁柏思,金鑫鑫,路又可,刘炯,王震凯,吴琳,汪芳裕,检测6种血清学抗体在120例炎症性肠病中的I临床应用价值,中华消化杂志,2015,35(4): 270-272

 20.王震凯,魏娟,吴琳,袁柏思,路又可,刘炯,金鑫鑫,杨妙芳,刘畅,汪芳裕,自体骨髓干细胞对肝硬化患者外周血淋巴细胞和免疫球蛋白的影响,中华细胞与干细胞杂志,2015,5(1):13-18

 21.王震凯,魏娟,吴琳,袁柏思,路又可,刘炯,金鑫鑫,杨妙芳,刘畅,汪芳裕,预测重症溃疡性结肠炎患者需手术治疗的临床指标,中华消化杂志,2014,34增刊

 22.魏娟,施慧,陆恒,汪芳裕,T-SPOT.TBPPD在消化系统结核感染鉴别诊断中的价值,胃肠病学和肝病学杂志,2014,23(3):289-291

 23.汪芳裕,肝硬化自体骨髓干细胞回输前后外周血免疫功能的变化,中华消化杂志, 2014,34(3):189-190

 24.王震凯,魏娟,吴琳,袁柏思,路又可,刘炯,金鑫鑫,杨妙芳,刘畅,汪芳裕,自体骨髓干细胞移植治疗肝硬化难治性腹水的临床观察,中华细胞与干细胞杂志,2014,4(4):6-10

 25.汪芳裕,张新华,周淑萍,袁柏思,林梅,王少东,路又可,刘炯,李晓华,周晓军,溃疡性结肠炎相关腺瘤和结直肠癌回顾性临床病例分析,胃肠病学杂志,2013,18(4):233-236

 26.王文辉,汪芳裕,魏娟,沈芸竹,刘畅,舒小闯,CpG甲基转移酶诱导紧密连接蛋白78基因表达下调对人结肠癌HT-29细胞增殖和凋亡的影响,中华肿瘤杂志,2013,35(6): 405-411


承担科研项目[项目负责人]



1.中草药来源的MiR-5368对溃疡性结肠炎的治疗作用与机制研究国家自然科学基金(818735592019

2.microRNA-17-92簇调控分化的骨髓间充质干细胞对实验性结肠炎黏膜修复的影响及其机制研究,国家自然科学基金(815705062016

3.COX-2调控的TLR4/NF-κB信号通路在溃疡性结肠炎相关异型增生及癌变中的作用机制研究,国家自然科学基金(812704532013

4.溃疡性结肠炎黏膜损伤与修复基因DNA甲基化的意义探讨,国家自然科学基金(810702892010


获奖情况

 1.《平坦型早期大肠癌和上皮内瘤变的内镜诊治系列研究》,全军医疗成果二等奖(2010-2-10-1

 2.《内镜下黏膜切除术治疗平坦型早期大肠癌和上皮内瘤变》,江苏省医疗新技术引进奖1等奖([2009]19号)

3.《轻便手动式内镜下粉剂药物喷洒枪》,国家发明专利(证书号:421543