王汉东

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:3

 

士研究生导师简介

姓名

王汉东

研究方向

神经外科

 

   专业:

外科学

联系方式

电话025-80861110

Email:njhdwang@163.com

学术兼职:

1.中国医师协会神经外科医师分会常委       

2.中华医学会神经外科分会委员       

3.江苏省医学会第七届神经外科分会主任委员      

4.江苏省医师协会第七届神经外科医师分会主任委员

5.中国人民解放军神经外科专业委员会常委

6.南京军区神经外科专业委员会主任委员

7.南京市医学会神经外科分会名誉主委     

8.中国研究型医院学会委员

9.任10余种专科学术杂志编委

 

个人简介

 

王汉东 南京军区南京总医院神经外科主任、中国人民解放军神经外科研究所所长、医学博士学位、主任医师、教授、博士生导师、博士后指导老师。中国医师协会神经外科医师分会常委,中华医学会神经外科分会委员,全军神经外科专业委员会常委,江苏省医学会神经外科分会名誉主任委员,南京军区神经外科专业委员会主任委员,南京医学会神经外科分会名誉主任委员,并担任中华神经外科杂志、中华外科杂志、中华实验外科杂志等十余种医学期刊的编委。

从医三十余年,临床经验丰富。擅长手术处理颅底肿瘤、脑干肿瘤、脑动脉瘤和脑血管畸形等神经外科疑难重症。江苏省首批医学重点人才;南京军区“122工程”全军级学科带头人。2011年获“江苏省第二届名医民选•百姓信任的医疗专家”荣誉称号,2013-2014连续两年获中国名医百强榜上榜名医。注重教学和科研,培养博士和硕士研究生共40余人。有包括国家自然科学基金在内的多项课题在研。以第一作者或通讯作者身份发表论文100余篇,其中SCI论文50余篇。获军队和省部级奖多项。

代表性论文

1.Sulphoraphane enhances aquaporin-4 expression and decreases spinal cord oedema following spinal cord injury. Brain Injury 2011;25:300-306. IF 1.533

2.Peripheral ophthalmic artery aneurysm. Neurosurgical Review 2011;34:29-38. IF 1.897

3.Intracranial meningeal melanocytoma associated with nevus of Ota. Journal of Clinical Neuroscience 2011; 18(11):1548-50. IF 1.164

4.Depletion of nrf2 enhances inflammation induced by oxyhemoglobin in cultured mice astrocytes. Neurochemical Research 2011.36(12):2434-41.IF 2.608

5.The Role of Nrf2 in Migration and Invasion of Human Glioma Cell U251.World Neurosurg,2011;IF 1.382

6.Transcription factor Nrf2 protects the spinal cord from inflammation produced by spinal cord injury. Journal of Surgical Research 2011.170(1):e105-15.IF 2.219

7.Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-κB pathway after traumatic brain injury in the rat. Mediators of Inflammation 2011.IF 1.395

8.Immersion autometallographic demonstration of pathological zinc accumulation in human acute neural diseases.Neurol Sci,2011;IF 1.220

9.Activation of the Nuclear Factor E2-Related Factor 2/Antioxidant Response Element Pathway Is Neuroprotective after Spinal Cord Injury.J Neurotrauma,2011; 28:1–10 .IF 3.129

10.Erythropoietin Administration Modulates Pulmonary Nrf2 Signaling Pathway After Traumatic Brain Injury in Mice.Journal of Trauma-Injury Infection and Critical Care,2011;71(3):680-686.IF 3.128

11.Protective effect of tert-butylhydroquinone on cerebral inflammatory response following traumatic brain injury in mice.Injury-International Journal of the Care of the Injured,2011;42(7):714-718.IF 2.269

12.Erythropoietin Prevents Secondary Brain Injury Induced by Cortical Lesion in Mice: Possible Involvement of Nrf2 Signaling Pathway.Annals of Clinical and Laboratory Science,2011;41(1):25-32.IF 1.016

13.Disruption of Nrf2 exacerbated the damage after spinal cord injury in mice.J Trauma,2012;72(1):189-98.IF 3.129

14.Zinc neurotoxicity to hippocampal neurons in vitro induces ubiquitin conjugation that requires p38 activation.Brain Res,2012;1438:1-7.IF 2.623

15.Expression and cell distribution of metabotropic glutamate receptor 5 in the rat cortex following traumatic brain injury. brain research, 2012, 1464: 73–81. IF 2.879

16.The absence of Nrf2 enhances NF-κB-dependent inflammation following scratch injury in mouse primary cultured astrocytes. mediators of inflammation, 2012, 2012: 217580. IF 3.882

17.Immersion autometallographic demonstration of pathological zinc accumulation in human acute neural diseases, neurological sciences, 2012, 33(4) : 855-861. IF1.412

18.Immunohistochemical study of NF-E2-related factor 2 (Nrf2) in an end-to-end anastomosis of the rat carotid artery. Journal of Cranio-Maxillofacial Surgery, 2012, 40(6): 516–520. IF 1.902

19.Management of hydrocephalus secondary to pineal region tumors. Clinical neurology and neurosurgery 2013.IF1.234

20.Knockdown of NF-E2-related factor 2 inhibits the proliferation and growth of U251MG human glioma cells in a mouse xenograft model. Oncology reports 2013; 30:157-64.IF2.297

21.Management of acute hydrocephalus due to pregnancy with ventriculoperitoneal shunt. Archives of gynecology and obstetrics 2013.IF1.330

22.Ethyl pyruvate ameliorates intracerebral hemorrhage-induced brain injury through anti-cell death and anti-inflammatory mechanisms. Neuroscience 2013; 245:99-108.IF 3.122

23.Erratum to: Immersion autometallographic demonstration of pathological zinc accumulation in human acute neural diseases. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013.

24.Zinc as mediator of ubiquitin conjugation following traumatic brain injury. Brain research 2013; 1506:132-41.IF2.879

25.Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats. Biochemical and biophysical research communications 2013; 430:1016-21.IF2.406

26.Knockdown of Nrf2 enhances autophagy induced by temozolomide in U251 human glioma cell line. Oncology reports 2013; 29:394-400.IF2.297

27.Chryseobacterium indologenes catheter-related meningitis in an elderly patient after intracranial aneurysm clipping surgery. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013.IF1.412

28.ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells. Oncology reports 2013; 30:715-22.IF2.297

29.Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice. Mediators of inflammation 2013; 2013:187873.IF3.882

30.Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1alpha. International journal of cancer Journal international du cancer 2013.IF6.198

31.Pretreatment with tert-butylhydroquinone attenuates cerebral oxidative stress in mice after traumatic brain injury. The Journal of surgical research 2013.IF2.119

32.海绵窦海绵状血管瘤的影像特征和显微手术[J]. 中华神经外科杂志,2011,27(5):462-465.

33.重视颅脑外伤患者的营养支持[J]. 中华神经外科杂志,2012,28(11):1081-1082.

34.岩斜区肿瘤的手术入路[J].中华神经外科杂志,2012,28(04).428-429

 

承担科研项目

1.Nrf2-ARE通路作为颅脑创伤治疗新靶点的实验研究  国家自然科学基金81070974 (2011.1-2013.12)课题经费27万元

2.南京军区122工程全军级学科带头人科研经费 军区卫生部 5万元

3.2011-2015江苏省医学重点学科 科研基金200万元

4.脑外伤后Nrf2-ARE通路对泛素-蛋白酶体系统的作用及机制研究   国家自然科学基金 81371357 (2014.1-2016.12) 课题经费70万

5.2013年  颅内动脉瘤治疗技术的规范化应用及治疗相关问题的“转化”研究  江苏省临床医学科技专项专病中心 科研基金200万 

科研获奖

1.2002年12月  弥漫性轴突损伤的临床与实验研究     军队科技进步二等奖(第一完成人)

2.2004年 经颅入路切除眶内或颅-眶沟通性肿瘤   军队医疗成果三等奖  (第一完成人)

3.2010年1月  颅内动脉瘤的基础与临床研究     教育部科技一等奖  (第三完成人)

4.2011年12月  Nrf2-ARE通路作为创伤性脑损伤治疗新靶点的实验研究      江苏医学科技二等奖(第一完成人) 

5.专利 2013年1月   用于经鼻手术的双极电凝颞  (专利号ZL2012 2 0347733.9)