吴锦慧

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:2273

 

博(硕)士研究生导师简介

姓名

吴锦慧

研究方向

药学和药剂新技术

联系方式

电话025-83596143

Email:wuj@nju.edu.cn

学术兼职:

美国药学会(AAPS)会员;

南京市医药学会委员

个人简介

1.      工作简历

2013.12-  南京大学 副教授

 

2.      科研情况简介

南京大学生物学博士,副教授,硕士生导师。 曾在哈佛-MIT健康科技研究中心,哈佛大学Wyss研究中心访学;获“青蓝工程”优秀青年骨干教师称号;在药剂递送、生物材料等领域著名期刊上发表SCI论文40余篇;受邀撰写专著2篇;主持国家自然科学基金、江苏省自然科学基金多项;参与医药科技重大专项1项;专利授权5项,1项获江苏省百件专利优质发明奖;担任Mol Pharm J NanomaterJ Mat Chem B等期刊的审稿人。

 

3.        研究兴趣

   药物制剂

   肿瘤药物的靶向递送

   新型药物递释系统

   制剂新理论和新技术

代表性论文

1.         Xuefeng Qiu; Yanting Zhang, Xiaozhi Zhao, Shiwei Zhang, Jinhui Wu*, Hongqian Guo; Yiqiao Hu. Enhancement of endothelial differentiation of adipose derived mesenchymal stem cells by a three-dimensional culture system of microwell. Biomaterials. (Accepted)

2.         Ahu Yuan, Xuefeng Qiu, Xiaolei Tang, Wei Liu, Jinhui Wu*, Yiqiao Hu* Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy. Biomaterials. (Accepted)

3.         Ahu Yuan, Xiaolei Tang, Xufeng Qiu, Jiang Ke, Jinhui Wu*, Yiqiao Hu*. Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes. Chem Commun (2014)

4.         Zheyi Hu, Zaigang Zhou, Yahui Hu, Jinhui Wu*, Yunman Li*, Wenlong Huang. HZ08 reverse P-glycoprotein mediated multidrug resistance in vitro and in vivo. PLOS one (2014)  

5.         Chenxiao Jiang; Hao Cheng; Ahu Yuan; Xiaolei Tang; Jinhui Wu*; Yiqiao Hu*. Hydrophobic IR780 Encapsulated in Biodegradable Human Serum Albumin Nanoparticles for Photothermal and Photodynamic Therapy. Acta Biomaterialia (2014)

6.         Tingsheng Lin, Yifan Zhang, Jinhui Wu*, Xiaozhi Zhao, Huibo Lian, Wei Wang, Hongqian Guo, Yiqiao Hu*. A Floating Hydrogel System Capable of Generating CO2 Bubbles to Diminish Urinary Obstruction After Intravesical Instillation. Pharmaceutical Research. April 2014.

7.         Lili Zhao, Ying Gao, Guoxiang Gu, Jinhui Wu*, Zhining Fan, Hong Dong and Yiqiao Hu*.  Rational design of drug-eluting stents via electrospray and in vivoevaluation of preventing oesophageal stricture. RSC Adv, 2014,4, 16885-16892.

8.         Jinhui Wu, Chenchen Song, Chenxiao Jiang, Xin Shen, Qian Qiao, Yiqiao Hu*. Nucleolin Targeting AS1411 Modified Protein Nanoparticle for Antitumor Drugs Delivery. Molecular Pharmaceutics. 2013 Oct 7;10(10):3555-63.

9.         Sai Zhao, Jinhui Wu*. Hypoxia Inducible Factor Stabilization As a Novel Strategy to Treat Anemia. Current Medicinal Chemistry, 2013, 20( 21), July , 2697-2711(15).

10.    Xiang Zhang, Lili Zhao, Jinhui Wu*, Hong Dong, Yiqiao Hu*, Current advances in vehicles for brain gene delivery. Current Gene Therapy. 2012,12(5),423-436.

11.    Guangming Gong, Yan Xu, Yuanyuan Zhou, Zhengjie Meng, Guoyan Ren, Yang Zhao, Xiang Zhang, Jinhui Wu*, Yiqiao Hu*. Molecular Switch For the Assembly of Lipophilic Drug Incorporated Plasma Protein Nanoparticles and In Vivo image. Biomacromolecules. 2012, 9;13(1):23-8.

12.     Lin Wu, Jinhui Wu*, Yuanyuan Zhou, Xiaolei Tang, Yiqiao Hu*. Enhanced antitumor efficacy and decreased
          side effects of platinum by tirapazamine-transferrin conjugate. International Journal of Pharmaceutics. 2012, Jul 
          15;431(1-2):190-6. 
13.     Lili Zhao, Jinhui Wu*, He Zhou, Ahu Yuan, Xiang Zhang, Feng Xu, Yiqiao Hu*. Local gene delivery for cancer
          therapy. Current Gene Therapy. 2011,11(5)423-442  
14.     Jinhui Wu, Ian WheeldonYuqi Guo, Tingli Lu, Yiqiao Hu, Ali Khademhosseni. A sandwiched microarray
          platform for benchtop cell-based high throughput screening. Biomaterials. 2011,32 (3) 841-848. 
15.     Jinhui Wu, Dawei Ding, Guoyan Ren, Xiangyang Xu, Xiaojin Yin, Yiqiao Hu. Sustained delivery of 
          endostatin improves the efficacy of therapy in Lewis lung cancer model. Journal of controlled release. 2009, 
          134 (2) 91-97. 

16.     Jinhui Wu, Lin Wu, Xiaoqiang Xu, Xiangyang Xu, Xiaojin Yin, Yingjie Chen, Yiqiao Hu. Microspheres made by W/O/O emulsion method with reduced initial burst for long-term delivery of Endostar, a novel recombinant human endostatin. Journal of Pharmaceutical Sciences. 2009, 98(6):2051-8. 

17.     Jinhui Wu, Qiujuan Wang, Jiyuan Guo, Zheyi Hu, Zhiyong Yin, Jinyi Xu, Xiaoming Wu. Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT1 receptor antagonist. European Journal of Pharmacology. 2008, 589(1-3):220-4.

 

* 通讯作者或者共同通讯作者

承担科研项目

Ø        高校“青蓝工程”优秀青年骨干教师。2014-2015

Ø        国家自然科学青年基金。气管味蕾"探索溶液苦味淬灭的规律,2013-2015

Ø        江苏省自然科学基金。以核酸为载体材料的肿瘤靶向平台的研究,2012-2014

高等学校博士学科点专项科研基金(新教师),DNA体作为小分子差别化递药体系的研究