陈慧君

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:582

硕士研究生导师简介

姓名

陈惠君

研究方向:

代谢与疾病

联系方式

电话83594785

Email:hjchen@nju.edu.cn

学术兼职:无

个人简介

1工作简历:1983年毕业于上海第二军医大学军医系;1997获日本京都大学医学院博士学位;1999-2009年在美国加州大学伯克利分校营养与毒理系从事科研工作;2010年至今,南京大学医学院教授。

2、科研情况简介:专注于亚铁氧化酶的结构、功能以及与机体代谢相关的研究。利用我们新创的多种亚铁氧化酶基因敲除小鼠,研究其对机体代谢的影响。


代表性论文

  1. Chen M, Zheng J, Liu G, Xu E, Wang J, Fuqua BK, Vulpe CD, Anderson GJ, Chen H*.Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage  by facilitating iron efflux.Redox Biology. 2018; 17: 432-439.

  2. Zheng J, Jiang R, Chen M, Maimaitiming Z, Wang J, Anderson GJ, Vulpe CD, Dunaief JL, Chen H*. Multi-copper ferroxidase deficient mice have increased brain iron concentrations and learning and memory deficits. Journal of Nutrition.2018; 148: 643-649.

  3. Zheng J, Chen M, Liu G, Xu E, Chen H.*Ablation of Hephaestin and Ceruloplasmin Results in Iron Accumulation in Adipocytes and Type 2 Diabetes.FEBS Lett. 2018; Jan 21. 12978.

  4. Jiang B, Liu G, Zheng J, Chen M, Maimaitiming Z, Chen M, Liu S, Jiang R, Fuqua BK, Dunaief JL, Vulpe CD, Anderson GJ, Wang H*, Chen H*. Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.Sci Rep. 2016; Dec 19;6:39470.

  5. Jiang R, Hua C, Wan Y, Jiang B, Hu H, Zheng J, Fuqua BK, Dunaief JL, Anderson GJ, David S, Vulpe CD, and Chen H*. Hephaestin and Ceruloplasmin Play Distinct but Interrelated Roles in Iron Homeostasis in Mouse Brain. Journal of Nutrition. 2015; 145: 1003-1009.

  6. Chen H*, Attieh ZK, Huang G, Regine Van Der Hee and Chris Vulpe. Decreased hephaestin expression and activity leads to decreased iron efflux fromdifferentiated Caco2 cells. Journal of Cellular Biochemistry. 2009;107: 803-808.

  7. Chen H, Attieh ZK, Syed BA, Kuo YM, Stevens V, Fuqua BK, Andersen HS, Naylor CE, Evans RW, Gambling L, Danzeisen R, Bacouri-Haidar M, Usta J, Vulpe CD and McArdle HJ. Identification of zyklopen, a new member of thevertebrate multicopper ferroxidase family, and characterization in rodents andhuman cells.Journal of Nutrition. 2010; 140: 1728-1735.

  8. Chen H, Attieh ZK, Gao H, Huang G, Su T, Ke W and Vulpe CD. Age-related changes in iron homeostasis in mouse ferroxidase mutants. Biometals. 2009; 22: 827-834.

  9. Chen H, Huang G, Su T, Gao H, Attieh ZK, McKie AT, Anderson GJ, Vulpe CD. Decreased hephaestin level and activity in copper deficient mice causesystemic iron deficiency. Journal of Nutrition. 2006; 136: 1236-1241.

  10. Chen H, Attieh ZK, Su T, Syed BA, Gao H, Alaeddine RM, Fox TC, Usta J, Naylor CE, Evans RW, McKie AT, Anderson GJ, Vulpe CD. Hephaestin is aferroxidase which maintains partial activity in the sex linked anemia mice.Blood. 2004;103: 3933-3939.

  11.  Kuo YM, Su T, Chen H, Attieh ZK, Syed BA, McKie AT, Anderson GJ, Gitschier J, Vulpe CD. Mislocalization of hephaestin, a multi-copper ferroxidaseinvolved in basolateral intestinal iron transport, in the sex-linked anaemia mouse. Gut. 2004; 53: 201-206.

  12. Chen H, Su T, Attieh ZK, Fox TC, McKie AT, Anderson GJ, Vulpe CD. Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic andnutritional iron deficiency.Blood. 2003;102:1893-1899.


承担科研项目

科研项目:

  1.  National Natural Science Foundation of China – 81072292 (2011-2013)

  2.  National Natural Science Foundation of China – 81273068 (2013-2016)

  3.  National Natural Science Foundation of China – 81773417 (2018-2021)

  4.  Li Ka Shing/ UC-Berkeley Research Award – Prof. Elizabeth C. Theil and Chinese Woman Scientist    Collaborator Prof. Chen Huijun  2011/01-12