王 勇

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:8

 

博(硕)士研究生导师简介

姓名

王勇

研究方向

生殖,代谢,遗传

联系方式

电话83594755

Email: yongwang@nju.edu.cn

 

个人简介

基础医学教授。教学工作:《正常人体结构学》、《组织学与胚胎学》、《生殖生物学》、《实验免疫学》、《实验动物学》以及《组织病理学》的教学。科研工作:多囊卵巢综合征(PCOS)发病机制研究,重点关注PCOS胰岛素抵抗、雄激素与卵泡发育以及遗传与表遗传;杀微生物剂药物研究,主要针对生殖道感染进行研究开发;卵巢早衰与多囊卵巢综合征对照研究;技术开发,主要针对生殖系统药物。

代表性论文

Zhang X, Zhang C, Shen S, Xia Yj, Yi L, Wang Y (通讯作者). Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Hum Reprod.2013 Nov;28(11):3074-85.

Wang Y (第一作者), Qu J, Wu X, Hou L, Erkkola R. Different phenotypes of polycystic ovary syndrome by Rotterdam criteria are differently steroidogenic but similarly insulin resistant. Fertility and Sterility_ 2010, 93(4):1362-1365.

Wang C, Gao C, Meng K, Qiao H, Wang Y (通讯作者). Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2. PLoS One. 2015 Mar 6;10(3):e0119348. doi: 10. 1371 /journal.pone.0119348.

Xia Y, Shen S, Zhang X, Deng Z, Xiang Z, Wang H, Yi L, Gao Q, Wang Y(通讯作者). Epigenetic pattern changes in prenatal female Sprague-Dawley rats following exposure to androgen. Reprod Fertil Dev. 2015 Mar 31. doi: 10.1071 /RD 14292.

Yong WANG , XiaoKe Wu, Yunxia Cao, Long Yi, Jianxiu Chen.  A microsatellite polymorphism (tttta)n in the promoter of CYP11a gene in Chinese women with polycystic ovary syndrome, Fertility and Sterility. 200686(1):223-226

Yong WANG , XiaoKe Wu, Yunxia Cao, Long Yi, Haijian Fan, Jianxiu Chen. Polymorphisms of PGCα (Gly482Ser) and PPARγ2 (Pro12Ala) Genes in Chinese Women with Polycystic Ovary Syndrome, Fertility and Sterility, 2006. 85(5): 1536-1540.

JunWei Qu, Yong Wang(共同第一作者), Xiaoke Wu, Lei Gao, Lihui Hou, et al. Insulin resistance directly contributes to androgenic potential within ovarian theca cells, Fertility and Sterility2009 ,91(5 ):1990-7.

Zhang, Xin-Lin, Zhang, Cheng-Wei, Xu, Pei, Liang, Feng-Jing, Che, Ye-Na, Xia, Yan-Jie, Cao, Yun-Xia, Wu, Xiao-Ke, Wang, Wen-Jun, Yi, Long, Gao, Qian, Wang, Yong (通讯作者). SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients. MOLECULAR MEDICINE REPORTS, 2012, 5(1):245-249.

Wang, Y , Wu, Z. -W., Zhang, L. -F., Wu, X. -K., Yi, L., Han, X. -D Effects of Ureaplasma    urealyticum infection on the male reproductive system in experimental rats. ANDROLOGIA,   2010, 42(5):297-301.

Ke L, Che YN, Cao YX, Wu XK, Hu YL, Sun HX, Liang FJ, Sun J, Yi L, Wang Y (通讯作者). Polymorphisms of the HSD17B6 and HSD17B5 genes in Chinese women with polycystic ovary syndrome. J Womens Health (Larchmt). 2010 Dec;19(12):2227-32.

Pei Xu; Yena Che; Yunxia Cao; XiaoKe Wu; Haixiang Sun; Fengjing Liang; Jing Sun, Lu Ke; Long Yi; Yong Wang (通讯作者). Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome, Journal of Assisted Reproduction and Genetics,  (2010) 27:23–28

Xia, Yanjie, Che, Yena, Zhang, Xinlin, Zhang, Chengwei, Cao, Yunxia, Wang, Wenjun, Xu, Pei, Wu, Xiaoke, Yi, Long, Wang, Yong (通讯作者). Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients, MOLECULAR MEDICINE REPORTS. 2012, 5(5): 1330-1334.

Guang-bin Xie, Pei Xu, Ye-na Che, Yan-jie Xia, Yun-xia Cao, Wen-jun Wang, Di Qiao, Xiao-ke Wu, Long Yi, Yong Wang (通讯作者) ,Microsatellite polymorphism in the fibrillin 3 gene and susceptibility to PCOS: a case–control study and meta-analysis. Reproductive BioMedicine Online (2013) 26, 168– 174

Zhang, Cheng-wei, Zhang, Xin-lin, Xia, Yan-jie, Cao, Yun-xia, Wang, Wen-jun, Xu, Pei, Che, Ye-na, Wu, Xiao-ke, Yi, Long,  Wang, Yong (通讯作者). Association between polymorphisms of the CYP11A1 gene and polycystic ovary syndrome in Chinese women. MOLECULAR BIOLOGY REPORTS, 2012, 39(8): 8379-8385.

Jin JL, Sun J, Ge HJ, Cao YX, Wu XK, Liang FJ, Sun HX, Ke L, Yi L, Wu ZW, Wang Y (共同通讯作者) (. Association between CYP19 gene SNP rs2414096 polymorphism and polycystic ovary syndrome in Chinese women. BMC Med Genet. 2009 Dec 16;10:139.

Liang FJ, Wu XK, Qu JW, Ke L, Sun J, Wang Y (通讯作者). Response of IGF and IL-6 to ovarian stimulation in PCOS and normal women. Syst Biol Reprod Med. 2009; 55(5-6): 227-35.

Sun J, Fan H, Che Y, Cao Y, Wu X, Sun HX, Liang F, Yi L, Wang Y (通讯作者). Association between ACE gene I/D polymorphisms and hyper- androgenism in women with polycystic ovary syndrome (PCOS) and controls. BMC Med Genet. 2009;10:64.

Xu P, Zhang XL, Xie GB, Zhang CW, Shen SM, Zhang XX, Cao YX, Wang WJ, Che YN, Xia YJ, Wu XK, Yi L, Wang Y (通讯作者). The (TTTA)npolymorphism in intron4 of CYP19 and the polycystic ovary syndrome risk in a Chinese population. Mol Biol Rep. 2013 Aug;40(8):5041-7.

Xu P, Shen SM, Zhang XL, Liang F, Xie GB, Yi L,Wang Y (通讯作者). Haplotypeanalysis of single nucleotide polymorphisms in anti-Müllerian hormone gene in Chinese PCOS women. Arch Gynecol Obstet. 2013 Jul;288(1):125-30.

Chen Wang, Chao Gao, Jun-Long Zhuang, Chao Ding, Yong Wang (通讯作者) A combined approach identifies three mRNAs that are down-regulated by microRNA-29b and promote invasion ability in the breast cancer cell line MCF-7, J Cancer Res Clin Oncol, (2012) 138:2127–2136

Chen J, Shen S, Tan Y, Xia D, Xia Y, Cao Y, Wang W, Wu X, Wang H, Yi L, Gao Q, Wang Y (通讯作者). The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome. J Ovarian Res. 2015 Mar 22;8(1):11. doi: 10.1186/s13048-015-0139-1.

Qu J, Che Y, Xu P, Xia Y, Wu X, Wang Y (通讯作者). The Higher Response of Vascular Endothelial Growth Factor and Angiotensin-II to Human Chorionic Gonadotropin in Women with Polycystic Ovary Syndrome. Int J Fertil Steril. 2015 Jan-Mar;8(4):373-8.

 

承担科研项目

主持国家自然科学基金

1p66shc调控PCOS卵巢纤维化病理的机理研究,在研

2PCOS雄激素代谢相关基因的遗传(htSNPs)与表遗传(DNA甲基化)调控机制研究,在研

3、胰岛素信号系统相关基因多态性与PCOS表型的关系探索

参与973项目:负责其中多囊卵巢综合征(PCOS)与卵巢早衰对比研究(结题)

      

参与国家科技重大专项2项:负责其中针对生殖道感染/用药安全评估进行研究开发(一项结题,一项在研)。

主持1项江苏省科技支撑计划项目:皮肤急性损伤保护剂的研发(结题)

主持7项企业委托项目