胡一桥

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:9

   

博(硕)士研究生导师简介

姓名

胡一桥

研究方向:

药学和药剂新技术

联系方式

电话:+86 25 83596143

Email: huyiqiao@nju.edu.cn, hu_yiqiao@163.com

学术兼职:

个人简介

1.        工作简历

1982-1989年,江苏省医药工业研究所

1989-2001年,中国药科大学药学院

2001-至今,南京大学生命科学学院

 

2.        科研情况简介

南京大学生物学博士,教授,博士生导师。曾在荷兰及美国访学;以药物缓控释及靶向技术为研究方向。在药剂递送、生物材料等领域著名期刊上发表SCI论文多篇;核心给药技术获得了多项国际和国内专利授权。先后获得了国家重大科技专项、国家九五攻关项目、自然科学基金等多项支持,并获得了多项国家及省级奖励。

 

3.        研究兴趣

   药物缓控释给药

   肿瘤及疾病细胞靶向

   制剂新理论和新技术

 

代表性论文

1.        Xuefeng Qiu; Yanting Zhang, Xiaozhi Zhao, Shiwei Zhang, Jinhui Wu, Hongqian Guo; Yiqiao Hu*. Enhancement of endothelial differentiation of adipose derived mesenchymal stem cells by a three-dimensional culture system of microwell. Biomaterials. (Accepted)

2.        Ahu Yuan, Xuefeng Qiu, Xiaolei Tang, Wei Liu, Jinhui Wu, Yiqiao Hu* Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy. Biomaterials. (Accepted)

3.        Ahu Yuan, Xiaolei Tang, Xufeng Qiu, Jiang Ke, Jinhui Wu*, Yiqiao Hu*. Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes. Chem Commun (2014)

4.        Chenxiao Jiang; Hao Cheng; Ahu Yuan; Xiaolei Tang; Jinhui Wu*; Yiqiao Hu*. Hydrophobic IR780 Encapsulated in Biodegradable Human Serum Albumin Nanoparticles for Photothermal and Photodynamic Therapy. Acta Biomaterialia (2014)

5.        Tingsheng Lin, Yifan Zhang, Jinhui Wu*, Xiaozhi Zhao, Huibo Lian, Wei Wang, Hongqian Guo, Yiqiao Hu*. A Floating Hydrogel System Capable of Generating CO2 Bubbles to Diminish Urinary Obstruction After Intravesical Instillation. Pharmaceutical Research. April 2014.

6.        Lili Zhao, Ying Gao, Guoxiang Gu, Jinhui Wu*, Zhining Fan, Hong Dong and Yiqiao Hu*.  Rational design of drug-eluting stents via electrospray and in vivoevaluation of preventing oesophageal stricture. RSC Adv, 2014,4, 16885-16892.

7.        Jinhui Wu, Chenchen Song, Chenxiao Jiang, Xin Shen, Qian Qiao, Yiqiao Hu*. Nucleolin Targeting AS1411 Modified Protein Nanoparticle for Antitumor Drugs Delivery. Molecular Pharmaceutics. 2013 Oct 7;10(10):3555-63.

8.        Xiang Zhang, Lili Zhao, Jinhui Wu*, Hong Dong, Yiqiao Hu*, Current advances in vehicles for brain gene delivery. Current Gene Therapy. 2012,12(5),423-436.

9.        Guangming Gong, Yan Xu, Yuanyuan Zhou, Zhengjie Meng, Guoyan Ren, Yang Zhao, Xiang Zhang, Jinhui Wu*, Yiqiao Hu*. Molecular Switch For the Assembly of Lipophilic Drug Incorporated Plasma Protein Nanoparticles and In Vivo image. Biomacromolecules. 2012, 9;13(1):23-8.

10.    Lin Wu, Jinhui Wu*, Yuanyuan Zhou, Xiaolei Tang, Yiqiao Hu*. Enhanced antitumor efficacy and decreased
         side effects of platinum by tirapazamine-transferrin conjugate. International Journal of Pharmaceutics. 2012, 
         Jul 15;431(1-2):190-6. 
11.    Lili Zhao, Jinhui Wu*, He Zhou, Ahu Yuan, Xiang Zhang, Feng Xu, Yiqiao Hu*. Local gene delivery for cancer
         therapy. Current Gene Therapy. 2011,11(5)423-442  
12.    Jinhui Wu, Dawei Ding, Guoyan Ren, Xiangyang Xu, Xiaojin Yin, Yiqiao Hu*. Sustained delivery of 
         endostatin improves the efficacy of therapy in Lewis lung cancer model. Journal of controlled release. 2009, 
         134 (2) 91-97. 

 

承担科研项目

国家自然科学基金(81473146):可示踪可激发体内双级递氧体系构建与评价

国家自然科学基金(81273464):MSC-前药酶/前药脑肿瘤精确给药系统

国家自然科学基金(30973651):分子对苦味物质真溶液的苦味自淬灭研究

国家自然科学基金(30070897):蛋白质在聚合物中的热稳定性与空间构象及生理活性的关系

重大新药创制国家科技重大专项:多西他赛白蛋白纳米粒靶向抗肿瘤的临床前研究

国家科技重大专项:蛋白质结肠定位给药系统

国家科技重大专项:盐酸非洛普缓释片