高 千

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:2764

士研究生导师简介

姓名

高千

研究方向

.代谢与疾病发生

遗传与相关疾病

联系方式

电话83595103

Email:qian-gao@nju.edu.cn

学术兼职:

个人简介

教授,博士生导师,美国宾夕法尼亚大学医学院神经生物学博士,浙江杭州人。

曾在国内接受完整的基础和临床医学训练,并先后在美国麻省理工学院和耶鲁大学医学院做博士后研究。

2004年受聘为耶鲁大学医学院助理教授,2007年受聘为南京大学医学院教授。

主要研究领域为代谢平衡的神经调控和发育遗传学。

代表性论文

1、Gao, Q. and Finkelstein, R. (1996) orthodenticle regulation during embryonic head development in Drosophila. Mechanism of Development 56:3-15.

2、Gao, Q. and Finkelstein, R. (1998) Targeting gene expression to the head: the Drosophila orthodenticle gene is a direct target of the Bicoid morphogen. Development. 125(21):4185-93.

3、Gao, Q. and Chess, A. (1999) Identification of candidate Drosophila olfactory receptors from genomic DNA sequence. Genomics 60:31-39.

4、Gao, Q., Yuan, B. and Chess, A. (2000) Convergent projections of Drosophila olfactory neurons to specific glomeruli in the antennal lobe. Nature Neuroscience 3(8):743-843.

5、Gao, Q., Kano, A., Wolfgang, M., Jacoby, J., Chai, G.X., Hansen, W., Iwamoto,.Y., Pober, J.S., Flavell, R.A., and Fu. X.Y. (2003) Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J Exp Med 198(10):1517-25. (co-first author).

6、Jacoby, J.J., Kalinowski, A., Liu, M., Zhang, S.S., Gao, Q., Chai, G.X., Ji, L., Iwamoto, Y., Li, E., Schneider, M., Russell, K.S., Fu, X.Y. (2003) Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis and heart failure with advanced age. PNAS 100(22):12929-34.

7、Gao, Q., Wolfgang, M.J., Neschen, S., Morino, K., Shulman, G.I., and Fu, X.Y. (2004) Disruption of neural STAT3 causes obesity, diabetes, infertility and thermal dysregulation. PNAS 101(13):4661-6.

8、Gao, Q., Hua, J., Kimura, R, Headd, J.J., Fu, X.Y., Chin, Y.E. (2004) STAT-Like SH2 domain in plants: the origin of SH2 domain. Molecular and Cellular Proteomics. 3(7):704-14.

9、Gao, Q., Abizaid, A., Horvath, T. (2006) Thoughts for food: brain mechanisms and peripheral energy balance. Neuron 51(6):691-702. (co-first author).

10、Gao, Q., Mezei, G., Nie, YZ., Rao, Y., Choi, CS., Bechmann, I., Leranth, C., Toran-Allerand, D., Priest, CA., Roberts, JL., Gao, XB., Mobbs, C., Shulman, GI., Diano, S., Horvath, TL. (2007) Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nature Medicine 13(1):89-94 (co-correspondence).

11、Gao, Q., Horvath, T. (2007) Neurobiology of Feeding and Energy Expenditure. The Annual Review of Neuroscienc 30:367-98.

12、Gao, Q., Horvath, T. (2008) Neuronal control of energy homeostasis. FEBS letter 582(1):132-41.

13、Gao, Q., Horvath, T. (2007) The hypothalamus. Encyclopedia of Neuroscience, Springer-Verlag (Invited book chapter).

14、Gao Q. (2008) Cross-talk between estrogen and leptin signaling in the hypothalamus. Am J Physiol Endocrinol Metab. 294(5):E817-26.

15、Nie, Y. Z., Yuan, Z. L., Horvath, T. L. and Gao, Q. (2007) Nutritional control of glucose homeostasis through Sirt1 deacetylation of STAT3 (Under review by Nature).

16、Nie Y, Erion DM, Yuan Z, Dietrich M, Shulman GI, Horvath TL, Gao Q.STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol.(2009)Apr;11(4):492-500. Epub 2009 Mar 22

承担科研项目

1、代谢调节研究,项目来源:美国糖尿病协会,项目经费30万美元,项目时间2008年月。

2、Stat3乙酰化调节,项目来源:美国DERC,项目经费:8万美元。

3、代谢与衰老的代谢与衰老的分子和临床医学研究,211三期重点学科建设项目,项目经费400万。