李宽钰

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:6

士研究生导师简介

姓名

李宽钰

研究方向

代谢与疾病发生

联系方式

电话025-8359-4765

Email: likuanyu@nju.edu.cn

学术兼职:

个人简介

1. 工作简历:

2009-至今,南京大学医学院

2004-2009,美国国家卫生研究院(NIH)

1999-2004,德国Justus-Liebig大学(GIESSEN)

1995-1999,南京大学生命科学院

奖励:NIH科研优秀奖(2007, 2008)

NIH优秀指导教师奖提名(2008)

德国政府科研人员交流基金(DAAD)资助(1999, 2010)

 

2. 科研情况简介:

    本实验室研究以“铁”和“线粒体”为中心开展基础研究和与临床相结合的转化医学研究,运用分子生物学,细胞生物学,动物模型和临床标本研究与铁的代谢和线粒体功能相关疾病的分子机理,同时实验室也开展临床前治疗方案的探索。研究方向包括:1)铁硫簇的合成转运与线粒体功能,2)神经退行性疾病神经元丢失与铁代谢的关系,3)巨噬细胞铁代谢异常在动脉粥样硬化发展中的作用,4)铁代谢异常与肿瘤生成

 

科研项目

国家自然科学基金(批准号: 31571218)与系统性红斑狼疮疾病关联基因TMEM187在线粒体铁代谢中的功能研究(2016.01.01-2019.12.31)

国家重点基础研究项目(“973”计划,课题编号: 2015CB856300):靶向线粒体代谢的分子探测与过程调控,技术骨干2015.01.01-2019.12.31

国家自然科学基金(批准号: 31371060):弗里德赖希氏共济失调病人神经元丢失的病理机制研究(2014.01.01-2017.12.31)

国家自然科学基金(批准号: 81370387)铁调控枢纽Hepcidin-Fpn1 在动脉粥样硬化进程中的作用及其机制研究(2014.01.01-2017.12.31)

国家自然科学基金(批准号: 31071085):弗里德赖希氏共济失调神经系统病变机制的研究(结题)

医药生物技术国家重点实验室研究基金(批准号: ZZYJ-SN-201006)弗里德赖希共济失调(FRDA)组织特异性的新型FXN亚型蛋白的调控和功能研究(结题)

回国人员启动基金(教外司留〔20101561号):弗里德赖希氏共济失调神经系统病变机制的研究(结题)

中央高校重点项目培育计划(项目编号:1094021412):线粒体铁的运输与调控(结题)

国家自然科学基金(批准号: 39900030):离子束注入对狐米草诱变的生物学效应及其机制的研究(结题)

 

代表性论文

Tang L, Cong Z, Hao S, Li P, Huang H, Shen Y*, Li K*, Jing H*. Protective effect of melatonin on the development of abdominal aortic aneurysm in a rat model. J Surg Res. 2017 Mar, 209: 266-278

Zhang H, Sun XR, Wang J, Zhang ZZ, Zhao HT, Li HH, Ji MH, Li KY*, Yang JJ*. Reactive Oxygen Species-mediated Loss of Phenotype of Parvalbumin Interneurons Contributes to Long-term Cognitive Impairments After Repeated Neonatal Ketamine Exposures. Neurotox Res. 2016 Nov;30(4):593-605

Sun X, Zhang H, Zhao HT, Ji MH, Li HH, Wu J, Li K*, Yang JJ*. Amelioration of oxidative stress-induced phenotype loss of parvalbumin interneurons might contribute to the beneficial effects of environmental enrichment in a rat model of post-traumatic stress disorder. Behav Brain Res 2016, 312:84-92

Zhang D, Zhang H, Hao S, Yan H, Zhang Z, Hu Y, Zhuang Z, Li W, Zhou M, Li K*, Hang C*. Akt Specific Activator SC79 Protects Against Early Brain Injury Following Subarachnoid Hemorrhage. ACS Chem Neurosci. 2016 Jun 15;7(6):710-8

Wang Q, Ji J, Hao S, Zhang M, Li K, Qiao T*. Iron together with lipid downregulates protein levels of ceruloplasmin in macrophages associated with rapid foam-cell formation. J Atheroscler Thromb 2016 Oct 1; 23(10): 1201–1211

Hao S, Song C, Shang L, Yu J, Qiao T* and Li K*. Phosphorylation of Akt by SC79 Prevents Iron Accumulation and Ameliorates Early Brain Injury in a Model of Experimental Subarachnoid Hemorrhage Molecules 2016, 21:325

Wu J, Zhang M, Li H, Sun X, Hao S, Ji M, Yang J*, Li K*. BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice. Behav Brain Res 2016, 305:115–121

Hao S, Ji J, Zhao H, Shang L, Wu J, Li H, Qiao T*, Li K*. Mitochondrion-targeted peptide SS-31 inhibited oxidized low-density lipoproteins-induced foam cell formation through both ROS scavenging and inhibition of cholesterol influx in RAW264.7 cells. Molecules 2015, 20(12):21287-21297

Xia H, Li B, Zhang Z, Wang Q, Qiao T, Li K*. Human glutaredoxin 3 can bind and effectivel, , y transfer [4Fe-4S] cluster to apo-iron regulatory protein 1. Biochem Biophys Res Commun 2015, 465(3):620-624

Wu J, Li H, Sun X, Zhang H, Hao S, Ji M, Yang JJ*, Li K*. The Mitochondrion-Targeted Antioxidant Ameliorates Isoflurane-Induced Cognitive Deficits in Aged Mice. PLoS ONE. 2015 Sep 17; 10(9): e0138256

Zhang D, Yan H, Li H, Hao S, Zhuang Z, Liu M, Sun Q, Yang Y, Zhou M, Li K*, Hang C*. TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage. J Biol Chem 2015, 290(32):19900-19909

Ji J, Zhou Y, Hao S, Wang Q, Li K*, Qiao T*. Low expression of ferroxidases is implicated in the iron retention in human atherosclerotic plaques. Biochem Biophys Res Commun.2015, 464(4):1134-1138

Hao S, Li J*, Li K*. An unusual case of iron deficiency anemia is associated with extremely low level of transferrin receptor. The International Journal of Clinical and Experimental Pathology. 2015, 8(7):8613-8618

Gao X, Hao S, Yan H, Ding W*, Li K*, Li J. Neutrophil extracellular traps contribute to the intestine damage in endotoxemic rats. Journal of Surgical Research. 2015, 95(1): 211–218

Yan H, Hao S, Sun X, Zhang D, Gao X, Yu Z, Li K*, Hang C*. Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage. Biochem Biophys Res Commun. 2015, 456(4): 835–840

Wu J, Zhang M, Hao S, Jia M, Ji M, Qiu L, Sun X, Yang J*, Li K*. Mitochondria-targeted peptide reverses mitochondrial dysfunction and cognitive deficits in sepsis-associated encephalopathy. Molecular Neurobiology. 2015, 52(1):783-791. IF: 5.286

Yan H, Zhang D, Hao S, Li K*, Hang C*. Role of mitochondrial calcium uniporter in early brain injury after experimental subarachnoid hemorrhage. Molecular Neurobiology. 2015, 52(3):1637-1647. IF: 5.286

Zhang D, Li H, Li T, Zhou M, Hao S, Yan H, Yu Z, Li W, Li K*, Hang C*. TLR4 inhibitor resatorvid provides neuroprotection in experimental traumatic brain injury: Implication in the treatment of human brain injury. Neurochem Int. 2014, Sep;75: 11-8.75C: 11-18.

Zhang D, Hu Y, Sun Q, Zhao J, Cong Z, Liu H, Zhou M, Li K*, Hang C*. Inhibition of transforming growth factor beta-activated kinase 1 confers neuroprotection after traumatic brain injury in rats. Neuroscience. 2013, 238: 209-17.

Xia H, Cao Y, Dai X, Marelja Z, Zhou D, Mo R, Al-Mahdawi S, Pook MA, Leimkühler S, Rouault TA, Li K*. Novel frataxin isoforms may contribute to the pathological mechanism of friedreich ataxia. PLoS One. 2012 7(10):e47847.

Li K*, Singh A, Crooks DR, Dai X, Cong Z, Pan L, Ha D, Rouault TA*. Expression of human frataxin is regulated by transcription factors SRF and TFAP2. PLoS One. 2010 5(8) e12286.

Li K, Besse EK, Ha D, Kovtunovych G, Rouault TA*. Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia. Hum Mol Genet. 2008 17 (15): 2265 -73.

Li K, Tong WH, Hughes RM, Rouault TA*. Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly. J Biol Chem. 2006 281(18):12344-51.

Zeller T, Mraheil MA, Moskvin OV, Li K, Gomelsky M, Klug G*. Regulation of hydrogen peroxide-dependent gene expression in Rhodobacter sphaeroides: regulatory functions of OxyR. J Bacteriol. 2007, 189(10):3784-92.

Zeller T, Li K, Klug G*. 2006 Expression of the trxC gene of Rhodobacter capsulatus: response to cellular redox status is mediated by the transcriptional regulator OxyR. J Bacteriol.188(21): 7689-95.

Zeller T, Moskvin OV, Li K, Klug G*, Gomelsky M*. 2005 Transcriptome and physiological responses to hydrogen peroxide of the facultatively phototrophic bacterium Rhodobacter sphaeroides. J Bacteriol. 187(21):7232-42.

Li K, Hein S, Zou W, Klug G*. 2004 The glutathione-glutaredoxin system in Rhodobacter capsulatus: part of a complex regulatory network controlling defense against oxidative stress. J Bacteriol. 186(20):6800-8.

Li K, Pasternak C, Härtig E, Haberzettl K, Maxwell A, Klug G*. 2004 Thioredoxin can influence gene expression by affecting gyrase activity. Nucleic Acids Res. 32(15):4563-75.

Li K, Pasternak C, Klug G*. 2003 Expression of the trxA gene for thioredoxin 1 in Rhodobacter sphaeroides during oxidative stress. Arch Microbiol. 180(6):484-9.

Li K, Härtig E, Klug G*. 2003 Thioredoxin 2 is involved in oxidative stress defence and redox-dependent expression of photosynthesis genes in Rhodobacter capsulatus. Microbiology. 149(2):419-30.