吴稚伟

文章来源:南京大学医学院发布时间:2017-07-03浏览次数:1831

博士研究生导师简介

姓名

吴稚伟

研究方向

细胞与分子免疫,分子药理学

联系方式

电话025-8368-6092

Email: wzhw@nju.edu.cn

学术兼职:

1.      Member, MPTi Steering Committee, CAMI/USAID/NIH, USA.

2.      Member, Association of Pacific Rim Universities (APRU), World Institute Public Health Steering Committee.

3.      教育部学位委员会

4.      南京大学科协 成员

个人简介

1.    工作简历

2005 - 现在, 教授。 南京大学医学院公共健康医学中心

2008 – 现在,教授,副主任,南京大学生命分析化学国家重点实验室

2006 - 现在,兼职研究员。英国南汉普顿大学社会和统计研究院

2007 – 现在,兼职副教授,纽约大学医学院,美国

2000-2005,  研究员, Leon levy 牙科研究中心,宾夕法尼亚大学牙医学院

1997-2000,助理教授,生物医学研究中心,洛克菲勒大学,美国;

 

2.    科研情况简介

(1)HIV-1的性传播分子(Sexual transmission)机理的研究

(2)HIV膜蛋白V1/V2, V3亚基(Domain)的结构及免疫原性的研究以及抗爱滋疫苗开发

(3)杀微生物剂在预防艾滋病性传播的应用基础研究

(4)诱导广中和抗体的基序疫苗(针对HIV、HPV、HSV、IFV和HCV等病毒)

(5)病毒感染和细胞相互作用及抗病毒分子机理研究

 

上述课题接受/曾接受国家自然基金、传染病重大专项、973及美国USAID、英国DEFID和法国BioMerieux的经费支持。

 

3.          研究兴趣

1 人体对艾滋病毒感染的抗体免疫反应和病毒免疫逃逸的分子机制,天然免疫在抑制病毒感染的作用,疫苗研究

2 病毒-细胞相互作用的分子机理,病毒性病原体黏膜感染的生物学及黏膜免疫

3)病毒侵入机制、抗病毒药物研究和杀微生物剂( Topical Microbicides)的研发

代表性论文

1.      Min Qiu, Qin Wang, Ying Chu, Zhongping Yuan, Hongyong Song, Zhiwei Chen, and Zhiwei Wu*. (2012) Lignosulfonic Acid Exhibits Broadly Anti-HIV-1 Activity – Potential as a Microbicide Candidate for the Prevention of HIV-1 Sexual Transmission. PLoS ONE 7(4): e35906. doi:10.1371/journal.pone.0035906.

2.      Zhongping Yuan, Xilin Wu, Chao Liu, Genxing Xu, and Zhiwei Wu*. Asymmetric siRNA: New strategy to improve specificity and reduce off-target gene expression. Human Gene Therapy. 2012; 23:521-532. doi: 10.1089hum.2011.145.

3.      Yuanxi Kang, Zhiwei Wu, Terrence C K Lau, Xiaofan Lu, Li Liu, Allen K L Cheung, Zhiwu Tan, Jenny Ng, Jianguo Liang, Haibo Wang, Saikam Li, Bojian Zheng, Ben Li, Li Chen, Zhiwei Chen. CCR5 antagonist TD-0680 uses a novel mechanism for enhanced potency against HIV-1 entry, cell-mediated infection, and a resistant variant. Journal of Biological Chemistry. 2012; 287(20):16499-509. DOI:10.1074/jbc.M112.354084.

4.      Qiu, M., Chen, Y., Song, S., Song, H., Chu, Y., Yuan, Z., Cheng, L., Zheng, D., Chen, Z., Wu, Z*. Poly (4-styrenesulfonic acid-co-maleic acid) is an entry inhibitor against both HIV-1 and HSV infections - potential as a dual functional microbicide, Antiviral Research (2012), 96 (2):138-147 doi:

5.      Pinter, A.; Wu, A. Z.; Neubert, T.; Burkhart, M. D.; Honnen, W. J. Conformational heterogeneity in V1/V2 domain affects the immunological properties of this region. Retrovirology. 2012 SEP 13;9 2 2.

6.      Min Qiu, Yu Chen, Lin Cheng, Yin Chu, Hong-Yong Song and Zhiwei Wu*. Pyrrolidine Dithiocarbamate Inhibits Herpes Simplex Virus 1 and 2 Replication, and Its Activity May Be Mediated through Dysregulation of the Ubiquitin-Proteasome System. Journal of Virology. August 2013 vol. 87 no. 15 8675-8686.

7.      D. Nutbeam, S. Padmadas, O. Maslovskaya, Z.W. Wu. A health promotion logic model to review progress in HIV prevention in China. Health Promotion International . June 9, 2013

8.      Min Qiu, Yin Chu, Si-Wei Song, Jie Gao, Na Yang, Xiao-Hui Wang, Zhi-Wei Wu*. Zinc ionophores pyrithione inhibits herpes simplex virus type 1 and 2 replication through interfering proteasome function and NF-κB activation. Antiviral Research (2013), 100 (1): 44–53.

9.      Ying Chu, Jiahuang Li, Xiling Wu, Zichun Hua, and Zhiwei Wu*. Identification of human immunodeficiency virus type 1 (HIV-1) gp120-binding sites on scavenger receptor cysteine rich 1 (SRCR1) domain of gp340. J. Biomedical Sci. 2013, 20:44.

10.  Song Hongyong,Chu Ying,Zhang Hongwei, Wang Xiaohui, Zhang Tong, Qiu Min, Wu Hao, Wu Zhiwei*. Epitope specificity of cross-clade neutralizing sera from Chinese HIV-1 positive individuals. Scandinavian Journal of Immunology 2013, 78, 357–370.

11.  Nan Zheng, Yanping Guo, Sabu Padmadas, Baoxi Wang, Zhiwei Wu*. The increase of STI infections calls for simultaneous preventative intervention for more effectively containing HIV epidemics in China. British Journal of Obstetrics and Gynaecology (In press).

12.  Siwei Song, Min Qiu, Ying Chu, Deyan Chen, Xiaohui Wang, Airong Su, Zhiwei Wu*. Berberine inhibits herpes simplex virus replication through modulating NF-κB and JNK pathways. Antimicrobial Agents and Chemotherapy (In press).

13.  Xiaowen Lv , Min Qiu, Deyan Chen, Nan Zheng, Yu Jin, Zhiwei Wu*. Apigenin and its analog, lutelin, inhibit enterovirus 71 replicaiton with distinct antiviral mechanisms. Antiviral Research (In revision).

承担科研项目

1.   人类免疫缺陷病毒生物学和免疫应答机制研究 – 基础研究重大专项(973)

2.   杀微生物剂在预防艾滋病性传播的应用基础研究 - 十一五重大传染病专项

3.   抗HIV及病原微生物阻断药物的研究与开发 - 科技部国际合作

4.   新型杀微生物剂的临床前和临床研究 - 十二五重大传染病专项

5.   诱导广中和抗体的HIV基序疫苗 - 十二五重大传染病专项

6.   Developing public health strategies to effectively tackle the spread of HIV/AIDS among the economic migrants of China - 英国文化协会/海外发展署(DEFID/BC)

7.   Design of an Innate Immune Component as a HIV-1 Entry Inhibitor - Merieux Research Grant

8.   Scientific, regulatory and public health aspects of microbicide research and development - 美国国际发展总署(USAID)